The Role of Cancer-Associated Fibroblasts in Tumor Progression

Tumor Cells and Cancer-Associated Fibroblasts: An Updated Metabolic Perspective

(2021) Géraldine Gentric et al.   Cancers

Diminished CD68+ Cancer-Associated Fibroblast Subset Induces Treg Infiltration and Predicts Poor Prognosis of Oral Squamous Cell Carcinoma Patients

(2020) Xingxing Zhao et al.   AMERICAN JOURNAL OF PATHOLOGY

Nintedanib inhibits intrahepatic cholangiocarcinoma aggressiveness via suppression of cytokines extracted from activated cancer-associated fibroblasts

(2020) Takahiro Yamanaka et al.   BRITISH JOURNAL OF CANCER

VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling

(2020) Zhuan Zhou et al.   CANCER LETTERS

Cancer‐associated fibroblasts that restrain cancer progression (rCAFs): hypotheses and perspectives

(2020) Yuki Miyai et al.   CANCER SCIENCE

Expression of lncRNAs in cancer‐associated fibroblasts linked to patient survival in ovarian cancer

(2020) Emily K. Colvin et al.   CANCER SCIENCE

Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

(2020) Hannes Neuwirt et al.   Cell Communication and Signaling

Cancer-associated fibroblasts in cholangiocarcinoma

(2020) Javier Vaquero et al.   CURRENT OPINION IN GASTROENTEROLOGY

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts

(2020) Chi Shu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression

(2020) Tianyu Shen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

(2020) Haiyang Zhang et al.   Molecular Cancer

FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

(2020) Hsin-Jung Wu et al.   ONCOGENE

Cancer-associated fibroblasts-derived VCAM1 induced by H. pylori infection facilitates tumor invasion in gastric cancer

(2020) Jiajia Shen et al.   ONCOGENE

Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer

(2020) Sevda Salimifard et al.   PATHOLOGY RESEARCH AND PRACTICE

P53 Mutant p53N236S Regulates Cancer-Associated Fibroblasts Properties Through Stat3 Pathway

(2020) Qing Liu et al.   OncoTargets and Therapy

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome

(2020) Artur Mezheyeuski et al.   Scientific Reports

Cancer-associated fibroblasts promote immunosuppression by inducing ROS-generating monocytic MDSCs in lung squamous cell carcinoma

(2020) Handan Xiang et al.   Cancer Immunology Research

Exosomal Sonic Hedgehog derived from cancer‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma

(2020) Guiping Zhao et al.   Cancer Medicine

CD66b + neutrophils and α‐SMA + fibroblasts predict clinical outcomes and benefits from postoperative chemotherapy in gastric adenocarcinoma

(2020) Xiliang Cong et al.   Cancer Medicine

Cancer Associated Fibroblasts and Senescent Thyroid Cells in the Invasive Front of Thyroid Carcinoma

(2020) Emanuela Minna et al.   Cancers

Exosomal miRNA-34 from cancer-associated fibroblasts inhibits growth and invasion of gastric cancer cells in vitro and in vivo

(2020) Liang Shi et al.   Aging-US

Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity

(2020) Barbara Érsek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

miR-210 transferred by lung cancer cell-derived exosomes may act as proangiogenic factor in cancer-associated fibroblasts by modulating JAK2/STAT3 pathway

(2020) Junqiang Fan et al.   CLINICAL SCIENCE

Cancer‐associated fibroblasts: activin A adds another string to their bow

(2020) Remi Samain et al.   EMBO Molecular Medicine

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming

(2020) Michael Cangkrama et al.   EMBO Molecular Medicine

Cancer associated fibroblasts: role in breast cancer and potential as therapeutic targets

(2020) Rosamaria Lappano et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling

(2020) Zheng Zhou et al.   FASEB JOURNAL

MiR ‐3613‐3p from carcinoma‐associated fibroblasts exosomes promoted breast cancer cell proliferation and metastasis by regulating SOCS2 expression

(2020) Yonglei Liu et al.   IUBMB LIFE

Exosome-mediated transfer of miR-93-5p from cancer-associated fibroblasts confer radioresistance in colorectal cancer cells by downregulating FOXA1 and upregulating TGFB3

(2020) Xijuan Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TRAF6 Activates Fibroblasts to Cancer-Associated Fibroblasts through FGF19 in Tumor Microenvironment to Benefit the Malignant Phenotype of Melanoma Cells

(2020) Yeye Guo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cancer associated fibroblast FAK regulates malignant cell metabolism

(2020) Fevzi Demircioglu et al.   Nature Communications

Cancer associated fibroblasts confer shear resistance to circulating tumor cells during prostate cancer metastatic progression

(2020) Nerymar Ortiz-Otero et al.   Oncotarget

Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype

(2020) Lei Liu et al.   EXPERIMENTAL CELL RESEARCH

Breast cancer-derived exosomes regulate cell invasion and metastasis in breast cancer via miR-146a to activate cancer associated fibroblasts in tumor microenvironment

(2020) Shan-Shan Yang et al.   EXPERIMENTAL CELL RESEARCH

Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel

(2020) Thibaut Fourniols et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cancer-Associated Fibroblasts: Understanding Their Heterogeneity

(2020) Kévin Louault et al.   Cancers

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

(2019) Mohammad Awaji et al.   Cancers

Cancer-associated fibroblasts in gastrointestinal cancer

(2019) Hiroki Kobayashi et al.   Nature Reviews Gastroenterology & Hepatology

In search of definitions: Cancer-associated fibroblasts and their markers

(2019) Martin Nurmik et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

(2019) Micol Eleonora Fiori et al.   Molecular Cancer

Short-term 3D culture systems of various complexity for treatment optimization of colorectal carcinoma

(2019) Marloes Zoetemelk et al.   Scientific Reports

A DNA vaccine expressing an optimized secreted FAPα induces enhanced anti-tumor activity by altering the tumor microenvironment in a murine model of breast cancer

(2019) Fei Geng et al.   VACCINE

Role of Cancer-Associated Fibroblast in Gastric Cancer Progression and Resistance to Treatments

(2019) In-Hye Ham et al.   Journal of Oncology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Fibronectin in malignancy: Cancer-specific alterations, protumoral effects, and therapeutic implications

(2019) Jonathan W Rick et al.   SEMINARS IN ONCOLOGY

The role of cancer-associated fibroblasts in renal cell carcinoma. An example of tumor modulation through tumor/non-tumor cell interactions

(2019) Peio Errarte et al.   Journal of Advanced Research

TMIC-22. IDENTIFICATION OF CANCER-ASSOCIATED FIBROBLASTS IN GLIOBLASTOMA and Defining Their Protumoral Effects

(2019) Jonathan Rick et al.   NEURO-ONCOLOGY

Metabolic landscape of the tumor microenvironment at single cell resolution

(2019) Zhengtao Xiao et al.   Nature Communications

Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A

(2019) Hua Guo et al.   Cancer Cell International

High COX‐2 expression in cancer‐associated fibiroblasts contributes to poor survival and promotes migration and invasiveness in nasopharyngeal carcinoma

(2019) Yinghong Zhu et al.   MOLECULAR CARCINOGENESIS

NLRP3 Inflammasome Mediated Interleukin-1β Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma

(2019) Shu Nie et al.   Cancer Management and Research

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

(2018) Ana Costa et al.   CANCER CELL

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Cancer-Associated Fibroblasts Affect Intratumoral CD8+and FoxP3+T Cells via Interleukin 6 in the Tumor Microenvironment

(2018) Takuya Kato et al.   CLINICAL CANCER RESEARCH

Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2)

(2018) Kaitlyn M. Dvorak et al.   PLoS One

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

(2018) Anne-Marie Givel et al.   Nature Communications

The prognostic significance of carcinoma-associated fibroblasts and tumor-associated macrophages in nasopharyngeal carcinoma

(2018) Yahui Yu et al.   Cancer Management and Research

Isolation of cancer-associated fibroblasts and its promotion to the progression of intrahepatic cholangiocarcinoma

(2018) Meng Sha et al.   Cancer Medicine

Cancer-associated fibroblasts promote progression and gemcitabine resistance via the SDF-1/SATB-1 pathway in pancreatic cancer

(2018) Lusheng Wei et al.   Cell Death & Disease

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma

(2018) Baojia Zou et al.   Cancer Management and Research

Cancer-associated fibroblasts secrete FGF-1 to promote ovarian proliferation, migration, and invasion through the activation of FGF-1/FGFR4 signaling

(2017) Yuanzhen Sun et al.   TUMOR BIOLOGY

Overexpression of α-sma-positive fibroblasts (CAFs) in Nasopharyngeal Carcinoma Predicts Poor Prognosis

(2017) Jiewei Chen et al.   Journal of Cancer

The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas

(2016) Yoshihiro Mezawa et al.   CELL AND TISSUE RESEARCH

Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth

(2016) Lifeng Yang et al.   Cell Metabolism

Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis

(2016) Fei Teng et al.   Journal of Hematology & Oncology

Collaboration of cancer-associated fibroblasts and tumour-associated macrophages for neuroblastoma development

(2016) Okito Hashimoto et al.   JOURNAL OF PATHOLOGY

Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets

(2016) Yufang Shi et al.   NATURE REVIEWS DRUG DISCOVERY

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

(2016) Hideyuki Takahashi et al.   Oncotarget

Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential

(2016) Erik S. Knudsen et al.   Oncotarget

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Insight On Colorectal Carcinoma Infiltration by Studying Perilesional Extracellular Matrix

(2016) Manuela Nebuloni et al.   Scientific Reports

FGF-1/-3/FGFR4 signaling in cancer-associated fibroblasts promotes tumor progression in colon cancer through Erk and MMP-7

(2015) Yu-Pan Bai et al.   CANCER SCIENCE

Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma

(2015) Shinya Neri et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: an immunohistochemical analysis

(2015) Hye Min Kim et al.   Journal of Translational Medicine

Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro

(2015) Jana Trylcova et al.   TUMOR BIOLOGY

Expression of cancer-associated fibroblast-related proteins in adipose stroma of breast cancer

(2015) Yoon Yang Jung et al.   TUMOR BIOLOGY

TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

(2015) Junlong Zhuang et al.   Scientific Reports

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

(2015) Kamolporn Amornsupak et al.   BMC CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Downregulation of FAP suppresses cell proliferation and metastasis through PTEN/PI3K/AKT and Ras-ERK signaling in oral squamous cell carcinoma

(2014) H Wang et al.   Cell Death & Disease

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

(2014) Wan-Jiun Chen et al.   Nature Communications

Relationships of Alpha-SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma

(2014) Shumin Wang et al.   Biomed Research International

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling

(2013) Y Yu et al.   BRITISH JOURNAL OF CANCER

Clear cell renal cell carcinoma induces fibroblast-mediated production of stromal periostin

(2013) Nazihah Bakhtyar et al.   EUROPEAN JOURNAL OF CANCER

Bone marrow cells as precursors of the tumor stroma

(2013) Daniel L. Worthley et al.   EXPERIMENTAL CELL RESEARCH

Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

(2013) E Serres et al.   ONCOGENE

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-smooth muscle actin-positive fibroblasts correlate with poor survival in hepatocellular carcinoma

(2013) JIGNESH G. PARIKH et al.   Oncology Letters

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

(2013) Younghun Jung et al.   Nature Communications

Cancer-associated fibroblasts and macrophages

(2013) Paola Chiarugi   OncoImmunology

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Cancer-Associated Fibroblasts Induce Matrix Metalloproteinase-Mediated Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma Cells

(2012) A.-C. Johansson et al.   MOLECULAR CANCER RESEARCH

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Matrix Rigidity Regulates Cancer Cell Growth by Modulating Cellular Metabolism and Protein Synthesis

(2012) Robert W. Tilghman et al.   PLoS One

G-protein-coupled estrogen receptor GPR30 and tamoxifen resistance in breast cancer

(2011) Atanas Ignatov et al.   BREAST CANCER RESEARCH AND TREATMENT

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma

(2011) Alphonse E Sirica et al.   CURRENT OPINION IN GASTROENTEROLOGY

Extracellular matrix players in metastatic niches

(2011) Thordur Oskarsson et al.   EMBO JOURNAL

Role of cancer-associated fibroblasts in breast cancer development and prognosis

(2011) Abdelilah Aboussekhra   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Human Lung Parenchyma but Not Proximal Bronchi Produces Fibroblasts with Enhanced TGF-β Signaling and α-SMA Expression

(2010) Dmitri V. Pechkovsky et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer

(2010) Ibrahim O. Bello et al.   ORAL ONCOLOGY

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth

(2009) E. Pazolli et al.   CANCER RESEARCH

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Distinct progression-associated expression of tumor and stromal MMPs in HaCaT skin SCCs correlates with onset of invasion

(2009) Silvia Vosseler et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice

(2009) Angélica M. Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer

(2009) Pierre Farmer et al.   NATURE MEDICINE

Alpha-smooth muscle actin-positive fibroblasts promote biliary cell proliferation and correlate with poor survival in cholangiocarcinoma

(2009) Thuwajit   ONCOLOGY REPORTS

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance

(2008) Paola Allavena et al.   IMMUNOLOGICAL REVIEWS