Extracellular Vesicles Are Key Regulators of Tumor Neovasculature

Vasculogenic Mimicry: A Promising Prognosticator in Head and Neck Squamous Cell Carcinoma and Esophageal Cancer? A Systematic Review and Meta-Analysis

(2020) Roosa Hujanen et al.   Cells

Tumor microenvironment complexity and therapeutic implications at a glance

(2020) Roghayyeh Baghban et al.   Cell Communication and Signaling

Exosomal miRNAs in tumor microenvironment

(2020) Shiming Tan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Extracellular Vesicles Released by Tumor Endothelial Cells Spread Immunosuppressive and Transforming Signals Through Various Recipient Cells

(2020) Tatiana Lopatina et al.   Frontiers in Cell and Developmental Biology

Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review)

(2019) Fang‑Tao Wang et al.   Oncology Letters

VEGF in Signaling and Disease: Beyond Discovery and Development

(2019) Rajendra S. Apte et al.   CELL

Tumor-educated platelets

(2019) Sjors G.J.G. In 't Veld et al.   BLOOD

The extracellular matrix in tumor progression and metastasis

(2019) Johannes A. Eble et al.   CLINICAL & EXPERIMENTAL METASTASIS

Exosome-orchestrated hypoxic tumor microenvironment

(2019) Wanrong Meng et al.   Molecular Cancer

Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts

(2019) Yutaka Naito et al.   ONCOGENE

Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis

(2019) Cory M. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels

(2019) Xiuhua Wu et al.   AUTOIMMUNITY REVIEWS

Endothelial-to-Mesenchymal Transition (EndoMT): Roles in Tumorigenesis, Metastatic Extravasation and Therapy Resistance

(2019) Valentin Platel et al.   Journal of Oncology

Extracellular Vesicles and Their Potential Use in Monitoring Cancer Progression and Therapy: The Contribution of Proteomics

(2019) Maria Concetta Cufaro et al.   Journal of Oncology

Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis

(2019) Ye Zeng et al.   Journal of Extracellular Vesicles

Extracellular vesicles in atherosclerosis

(2019) WenYi Deng et al.   CLINICA CHIMICA ACTA

Extracellular Vesicles Containing MicroRNA-92a-3p Facilitate Partial Endothelial-Mesenchymal Transition and Angiogenesis in Endothelial Cells

(2019) Nami O. Yamada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxic exosomes facilitate angiogenesis and metastasis in esophageal squamous cell carcinoma through altering the phenotype and transcriptome of endothelial cells

(2019) Yu Mao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fact or Fiction, It Is Time for a Verdict on Vasculogenic Mimicry?

(2019) Andrés Valdivia et al.   Frontiers in Oncology

Role of hypoxia in cancer therapy by regulating the tumor microenvironment

(2019) Xinming Jing et al.   Molecular Cancer

Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer

(2019) Changhao Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Matrix Metalloproteinases in Angiogenesis and Cancer

(2019) Saray Quintero-Fabián et al.   Frontiers in Oncology

Cancer-derived exosomes trigger endothelial to mesenchymal transition followed by the induction of cancer-associated fibroblasts

(2018) Ju Hun Yeon et al.   Acta Biomaterialia

Crosstalk between cancer cells and endothelial cells: implications for tumor progression and intervention

(2018) Hyojeong Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Cancer and platelet crosstalk: opportunities and challenges for aspirin and other antiplatelet agents

(2018) Xiaohong Ruby Xu et al.   BLOOD

Circulating small-sized endothelial microparticles as predictors of clinical outcome after chemotherapy for breast cancer: an exploratory analysis

(2018) Elisa García Garre et al.   BREAST CANCER RESEARCH AND TREATMENT

CD9-positive exosomes from cancer-associated fibroblasts stimulate the migration ability of scirrhous-type gastric cancer cells

(2018) Yuichiro Miki et al.   BRITISH JOURNAL OF CANCER

The Platelet Lifeline to Cancer: Challenges and Opportunities

(2018) Monika Haemmerle et al.   CANCER CELL

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

(2018) Juan Lu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Antiangiogenic therapy for patients with aggressive or refractory advanced non-small cell lung cancer in the second-line setting

(2018) Martin Reck et al.   LUNG CANCER

Extracellular vesicles characteristics and emerging roles in atherosclerotic cardiovascular disease

(2018) Anouar Hafiane et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exosomes Induce Fibroblast Differentiation into Cancer-Associated Fibroblasts through TGFβ Signaling

(2018) Cassandra Ringuette Goulet et al.   MOLECULAR CANCER RESEARCH

Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins

(2018) Kalpana Deepa Priya Dorayappan et al.   ONCOGENE

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Exosomes Play Roles in Sequential Processes of Tumor Metastasis

(2018) Keyu Li et al.   INTERNATIONAL JOURNAL OF CANCER

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

(2018) Chen-Fei Zhou et al.   ONCOGENE

Role of platelets and platelet receptors in cancer metastasis

(2018) Martin Schlesinger   Journal of Hematology & Oncology

Vasculogenic mimicry formation in EBV-associated epithelial malignancies

(2018) Tong Xiang et al.   Nature Communications

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

(2018) Muhammad Nawaz et al.   Cells

The Claudins: From Tight Junctions to Biological Systems

(2018) Sachiko Tsukita et al.   TRENDS IN BIOCHEMICAL SCIENCES

Extracellular vesicles for nucleic acid delivery: progress and prospects for safe RNA-based gene therapy

(2017) L Jiang et al.   GENE THERAPY

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

IL-3R-alpha blockade inhibits tumor endothelial cell-derived extracellular vesicle (EV)-mediated vessel formation by targeting the β-catenin pathway

(2017) Giusy Lombardo et al.   ONCOGENE

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Glioma cells enhance angiogenesis and inhibit endothelial cell apoptosis through the release of exosomes that contain long non-coding RNA CCAT2

(2017) Hai-Li Lang et al.   ONCOLOGY REPORTS

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

(2017) Zhe Huang et al.   ONCOLOGY RESEARCH

Breast-cancer extracellular vesicles induce platelet activation and aggregation by tissue factor-independent and -dependent mechanisms

(2017) Fausto G. Gomes et al.   THROMBOSIS RESEARCH

Vascular Mimicry: A Novel Neovascularization Mechanism Driving Anti-Angiogenic Therapy (AAT) Resistance in Glioblastoma

(2017) Kartik Angara et al.   Translational Oncology

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

(2017) Akira Yokoi et al.   Nature Communications

Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence

(2017) Aiko Sueta et al.   Oncotarget

Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis

(2016) J. P. Yang et al.   ANGIOGENESIS

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

The biology and function of exosomes in cancer

(2016) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma

(2016) Jian-Kai Yang et al.   JOURNAL OF NEURO-ONCOLOGY

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors

(2016) Shin Ito et al.   THROMBOSIS AND HAEMOSTASIS

The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression

(2016) M. Żmigrodzka et al.   TUMOR BIOLOGY

Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib

(2016) Maria Serova et al.   Oncotarget

Epithelial-to-endothelial transition and cancer stem cells: two cornerstones of vasculogenic mimicry in malignant tumors

(2016) Baocun Sun et al.   Oncotarget

Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells

(2016) Kyung Oh Jung et al.   Oncotarget

Knockdown of long non-coding RNA CCAT2 suppressed proliferation and migration of glioma cells

(2016) Hua Guo et al.   Oncotarget

Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion

(2015) Carlotta Tacconi et al.   GASTROENTEROLOGY

miR-221-induced PUMA silencing mediates immune evasion of bladder cancer cells

(2015) BIN FU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2

(2015) Olivier G. de Jong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

β-1,4-galactosyltransferase III suppresses extravillous trophoblast invasion through modifying β1-integrin glycosylation

(2015) W.-C. Liao et al.   PLACENTA

Micromanaging of tumor metastasis by extracellular vesicles

(2015) Naoomi Tominaga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

(2015) Ridwana Chowdhury et al.   Oncotarget

Endothelial-mesenchymal transition in normal human esophageal endothelial cells cocultured with esophageal adenocarcinoma cells: role of IL-1β and TGF-β2

(2014) Linghui Nie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities

(2014) Joseph C. Walsh et al.   ANTIOXIDANTS & REDOX SIGNALING

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1

(2014) T. Umezu et al.   BLOOD

Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response

(2014) S R McKeown   BRITISH JOURNAL OF RADIOLOGY

Cancer-Secreted miR-105 Destroys Vascular Endothelial Barriers to Promote Metastasis

(2014) Weiying Zhou et al.   CANCER CELL

MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells

(2014) Hai-Ying Wan et al.   CANCER LETTERS

Mechanisms of lymphatic metastasis

(2014) Sinem Karaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue factor in tumor microenvironment: a systematic review

(2014) Xiao Han et al.   Journal of Hematology & Oncology

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

(2014) Masayuki Shimoda et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes

(2014) M Aga et al.   ONCOGENE

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer

(2014) Chin-Chou Wang et al.   Biomed Research International

Exosomes

(2013) Huang-Ge Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

MicroRNA-9 inhibits vasculogenic mimicry of glioma cell lines by suppressing Stathmin expression

(2013) Yuwen Song et al.   JOURNAL OF NEURO-ONCOLOGY

Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2

(2013) Satoshi Takagi et al.   PLoS One

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Matrix Metalloproteinases

(2012) Laurie A. Shuman Moss et al.   AMERICAN JOURNAL OF PATHOLOGY

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition

(2012) Jason C. Kovacic et al.   CIRCULATION

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway

(2012) Guanglei Zhuang et al.   EMBO JOURNAL

Radical Cystectomy for Urothelial Carcinoma of the Bladder Without Neoadjuvant or Adjuvant Therapy: Long-Term Results in 1100 Patients

(2012) Richard E. Hautmann et al.   EUROPEAN UROLOGY

Transdifferentiation of Glioblastoma Stem-Like Cells into Mural Cells Drives Vasculogenic Mimicry in Glioblastomas

(2012) S. Scully et al.   JOURNAL OF NEUROSCIENCE

Coagulation activation and microparticle-associated coagulant activity in cancer patients

(2012) Frederiek van Doormaal et al.   THROMBOSIS AND HAEMOSTASIS

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling

(2011) Damian Medici et al.   BIOCHEMICAL JOURNAL

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism

(2011) Elena Campello et al.   THROMBOSIS RESEARCH

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

(2010) S. Rey et al.   CARDIOVASCULAR RESEARCH

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Formation of procoagulant microparticles and properties

(2010) Jean-Marie Freyssinet et al.   THROMBOSIS RESEARCH

The role of microparticles in the pathogenesis of rheumatic diseases

(2009) Christian Beyer et al.   Nature Reviews Rheumatology

Inflammation and cancer: Role of nuclear factor-kappaB activation

(2008) Shin Maeda et al.   CANCER SCIENCE

Platelet Microparticles: A Potential Predictive Factor of Survival in Hormone-Refractory Prostate Cancer Patients Treated with Docetaxel-Based Chemotherapy

(2008) Dominique Helley et al.   EUROPEAN UROLOGY

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

(2008) Pasquale Fasanaro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY