Cancer-associated fibroblasts support vascular growth through mechanical force

Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts

(2016) Kun Zhang et al.   JOURNAL OF CELL SCIENCE

Tumor-induced remote ECM network orientation steers angiogenesis

(2016) Hayri E. Balcioglu et al.   Scientific Reports

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

(2016) Callie A.S. Corsa et al.   Cell Reports

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

Notch1–Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration

(2015) Reza Riahi et al.   Nature Communications

Myocardial contraction and hyaluronic acid mechanotransduction in epithelial-to-mesenchymal transformation of endocardial cells

(2014) Mary Kathryn Sewell-Loftin et al.   BIOMATERIALS

Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis

(2014) J. Stanisavljevic et al.   CANCER RESEARCH

Probing the Biophysical Properties of Primary Breast Tumor-Derived Fibroblasts

(2014) Turi A. Alcoser et al.   Cellular and Molecular Bioengineering

A three-dimensional in vitro model of tumor cell intravasation

(2014) Seema M. Ehsan et al.   Integrative Biology

Differences between CAFs and their paired NCF from adjacent colonic mucosa reveal functional heterogeneity of CAFs, providing prognostic information

(2014) Mireia Berdiel-Acer et al.   Molecular Oncology

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis

(2014) E. Alspach et al.   Cancer Discovery

Flow shear stress regulates endothelial barrier function and expression of angiogenic factors in a 3D microfluidic tumor vascular model

(2014) Cara F Buchanan et al.   Cell Adhesion & Migration

Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migration

(2014) Daniel E Conway et al.   Cell Adhesion & Migration

Simultaneous Expression of Cancer Stem Cell-Like Properties and Cancer-Associated Fibroblast-Like Properties in a Primary Culture of Breast Cancer Cells

(2014) Mami Ishikawa et al.   Cancers

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

Opposing Signaling of ROCK1 and ROCK2 Determines the Switching of Substrate Specificity and the Mode of Migration of Glioblastoma Cells

(2013) Sonja Mertsch et al.   MOLECULAR NEUROBIOLOGY

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

In Vitro Perfused Human Capillary Networks

(2013) Monica L. Moya et al.   TISSUE ENGINEERING PART C-METHODS

Three-Dimensional Microfluidic Collagen Hydrogels for Investigating Flow-Mediated Tumor-Endothelial Signaling and Vascular Organization

(2013) Cara F. Buchanan et al.   TISSUE ENGINEERING PART C-METHODS

Mechano-sensing and transduction by endothelial surface glycocalyx: composition, structure, and function

(2013) Bingmei M. Fu et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation

(2011) Kun Zhang et al.   EMBO JOURNAL

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

(2011) Moshe Elkabets et al.   JOURNAL OF CLINICAL INVESTIGATION

Temporal and Spatial Cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition Predicts for Human Breast Cancer Recurrence

(2011) D. D. Tran et al.   MOLECULAR CANCER RESEARCH

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Cervical carcinoma-associated fibroblasts are DNA diploid and do not show evidence for somatic genetic alterations

(2011) Willem Ernst Corver et al.   CELLULAR ONCOLOGY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Activation of fibroblasts in cancer stroma

(2010) Kati Räsänen et al.   EXPERIMENTAL CELL RESEARCH

A distinctive role for focal adhesion proteins in three-dimensional cell motility

(2010) Stephanie I. Fraley et al.   NATURE CELL BIOLOGY

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Biomechanical regulation of blood vessel growth during tissue vascularization

(2009) Witold W Kilarski et al.   NATURE MEDICINE

Rapid Anastomosis of Endothelial Progenitor Cell–Derived Vessels with Host Vasculature Is Promoted by a High Density of Cotransplanted Fibroblasts

(2009) Xiaofang Chen et al.   TISSUE ENGINEERING PART A

The Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis

(2007) Cyrus M. Ghajar et al.   BIOPHYSICAL JOURNAL