Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression

(2016) Marta F. Estrada et al.   BIOMATERIALS

Targeting tumor–stroma crosstalk: the example of the NT157 inhibitor

(2015) T Rampias et al.   ONCOGENE

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

(2015) Albin Rudisch et al.   PLoS One

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

(2014) John A. Hickman et al.   Biotechnology Journal

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

A method for estimating the oxygen consumption rate in multicellular tumour spheroids

(2014) D. R. Grimes et al.   Journal of the Royal Society Interface

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells

(2014) Arno Amann et al.   PLoS One

An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models

(2014) Jonathan P. Celli et al.   Scientific Reports

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

(2014) Jean Albrengues et al.   Cell Reports

The perivascular niche regulates breast tumour dormancy

(2013) Cyrus M. Ghajar et al.   NATURE CELL BIOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

(2012) Silke Haubeiss et al.   Molecular Cancer

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2012) Ravid Straussman et al.   NATURE

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Integrating Macrophages into Organotypic Co-Cultures: A 3D In Vitro Model to Study Tumor-Associated Macrophages

(2012) Nina Linde et al.   PLoS One

Functional Screen of Paracrine Signals in Breast Carcinoma Fibroblasts

(2012) Gui Su et al.   PLoS One

Why the stroma matters in breast cancer

(2012) Matthew W. Conklin et al.   Cell Adhesion & Migration

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Phase III and submission failures: 2007–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Functional Heterogeneity of Breast Fibroblasts Is Defined by a Prostaglandin Secretory Phenotype that Promotes Expansion of Cancer-Stem Like Cells

(2011) Jenny A. Rudnick et al.   PLoS One

An Immunohistochemical Method to Study Breast Cancer Cell Subpopulations and Their Growth Regulation by Hormones in Three-Dimensional Cultures

(2011) Mauricio P. Pinto et al.   Frontiers in Endocrinology

Bioengineered 3D platform to explore cell–ECM interactions and drug resistance of epithelial ovarian cancer cells

(2010) Daniela Loessner et al.   BIOMATERIALS

The microenvironment determines the breast cancer cells' phenotype: organization of MCF7 cells in 3D cultures

(2010) Silva Krause et al.   BMC CANCER

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

Histologie fonctionnelle du derme

(2008) C. Prost-squarcioni et al.   ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Modulated expression of WFDC1 during carcinogenesis and cellular senescence

(2008) Shalom Madar et al.   CARCINOGENESIS

Evaluating Drug Efficacy and Toxicology in Three Dimensions: Using Synthetic Extracellular Matrices in Drug Discovery

(2007) Glenn D. Prestwich   ACCOUNTS OF CHEMICAL RESEARCH