Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

Mesenchymal Cells in Colon Cancer

(2017) Vasiliki Koliaraki et al.   GASTROENTEROLOGY

Modulation of cancer-specific immune responses by amino acid degrading enzymes

(2017) Elina Timosenko et al.   Immunotherapy

Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis

(2017) Ying Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils as active regulators of the immune system in the tumor microenvironment

(2017) Merav E. Shaul et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophils in cancer: prognostic role and therapeutic strategies

(2017) Alberto Ocana et al.   Molecular Cancer

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

Melanoma-associated fibroblasts decrease tumor cell susceptibility to NK cell-mediated killing through matrix-metalloproteinases secretion

(2017) Linda Ziani et al.   Oncotarget

Developmental and Functional Control of Natural Killer Cells by Cytokines

(2017) Yang Wu et al.   Frontiers in Immunology

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

(2017) Soumaya Kouidhi et al.   Frontiers in Immunology

Are Mast Cells MASTers in Cancer?

(2017) Gilda Varricchi et al.   Frontiers in Immunology

Acquisition of tumor cell phenotypic diversity along the EMT spectrum under hypoxic pressure: Consequences on susceptibility to cell-mediated cytotoxicity

(2017) Stéphane Terry et al.   OncoImmunology

Pancreatic cancer cell/fibroblast co-culture induces M2 like macrophages that influence therapeutic response in a 3D model

(2017) Janina Kuen et al.   PLoS One

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

(2016) Xuguang Yang et al.   CANCER RESEARCH

Fibroblast activation in cancer: when seed fertilizes soil

(2016) Sanya-Eduarda Kuzet et al.   CELL AND TISSUE RESEARCH

Immunosuppressive activities of adenosine in cancer

(2016) Bertrand Allard et al.   CURRENT OPINION IN PHARMACOLOGY

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

(2016) Philippe Gascard et al.   GENES & DEVELOPMENT

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

(2016) Hong Jiang et al.   NATURE MEDICINE

Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells

(2016) Y Deng et al.   ONCOGENE

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

(2016) S Chouaib et al.   ONCOGENE

Pericyte–fibroblast transition promotes tumor growth and metastasis

(2016) Kayoko Hosaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures

(2016) Elizabete Bagordakis et al.   TUMOR BIOLOGY

Genetic alterations and epigenetic alterations of cancer-associated fibroblasts

(2016) Heng Du et al.   Oncology Letters

Depletion of FAP+ cells reduces immunosuppressive cells and improves metabolism and functions CD8+T cells within tumors

(2016) Ying Zhang et al.   Oncotarget

Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis

(2016) Ya-Ling Hsu et al.   Oncotarget

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

(2016) Hideyuki Takahashi et al.   Oncotarget

The application of the fibroblast activation protein α-targeted immunotherapy strategy

(2016) Guan-Min Jiang et al.   Oncotarget

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

(2016) Callie A.S. Corsa et al.   Cell Reports

The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

(2016) Kankana Bardhan et al.   Frontiers in Immunology

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

(2016) Yu-Ling Li et al.   Cancer Biology & Medicine

Hypoxia: a key player in antitumor immune response. A Review in the Theme: Cellular Responses to Hypoxia

(2015) Muhammad Zaeem Noman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

(2015) Alexandra Fullár et al.   BMC CANCER

New horizons in tumor microenvironment biology: challenges and opportunities

(2015) Fei Chen et al.   BMC Medicine

Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma

(2015) Hideyuki Takahashi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

(2015) A. Lo et al.   CANCER RESEARCH

Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine

(2015) Yasuhiko Ohshio et al.   CANCER SCIENCE

Aberrant DNA methylation in non-small cell lung cancer-associated fibroblasts

(2015) Miguel Vizoso et al.   CARCINOGENESIS

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

(2015) Pu Li et al.   CELL RESEARCH

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Combination cancer immunotherapy and new immunomodulatory targets

(2015) Kathleen M. Mahoney et al.   NATURE REVIEWS DRUG DISCOVERY

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Cancer-associated fibroblasts promote angiogenesis in gastric cancer through galectin-1 expression

(2015) Dong Tang et al.   TUMOR BIOLOGY

TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT

(2015) Junlong Zhuang et al.   Scientific Reports

Th17 Cell Plasticity and Functions in Cancer Immunity

(2015) Leslie Guéry et al.   Biomed Research International

Critical Role of Tumor Microenvironment in Shaping NK Cell Functions: Implication of Hypoxic Stress

(2015) Meriem Hasmim et al.   Frontiers in Immunology

How Neutrophils Shape Adaptive Immune Responses

(2015) Pieter H. C. Leliefeld et al.   Frontiers in Immunology

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man

(2015) Verena K. Raker et al.   Frontiers in Immunology

Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment

(2015) Luca Danelli et al.   OncoImmunology

Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors

(2015) Constantin Jotzu et al.   Analytical Cellular Pathology

A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts

(2015) Meihua Chen et al.   Scientific Reports

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin β1

(2014) Xu-Jun He et al.   CANCER SCIENCE

Prevailing Role of Contact Guidance in Intrastromal T-cell Trapping in Human Pancreatic Cancer

(2014) N. Hartmann et al.   CLINICAL CANCER RESEARCH

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Tumor Plasticity Interferes with Anti-Tumor Immunity

(2014) Salem Chouaib et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Development and Function of Dendritic Cell Subsets

(2014) Alexander Mildner et al.   IMMUNITY

Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology

(2014) Gabor Valcz et al.   JOURNAL OF CLINICAL PATHOLOGY

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction

(2014) R. J. Lebbink et al.   JOURNAL OF IMMUNOLOGY

TGF-  Utilizes SMAD3 to Inhibit CD16-Mediated IFN-  Production and Antibody-Dependent Cellular Cytotoxicity in Human NK Cells

(2014) R. Trotta et al.   JOURNAL OF IMMUNOLOGY

TGF- -inducible microRNA-183 silences tumor-associated natural killer cells

(2014) S. S. Donatelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

(2014) James Harper et al.   SEMINARS IN CANCER BIOLOGY

CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful

(2014) H.-J. Kim et al.   Cancer Immunology Research

The Carcinoma-Associated Fibroblast Expressing Fibroblast Activation Protein and Escape from Immune Surveillance

(2014) D. T. Fearon   Cancer Immunology Research

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

(2014) Damya Laoui et al.   Frontiers in Immunology

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

EMT impairs breast carcinoma cell susceptibility to CTL-mediated lysis through autophagy induction

(2013) Intissar Akalay et al.   Autophagy

Fibroblast-mediated drug resistance in cancer

(2013) Kim H.T. Paraiso et al.   BIOCHEMICAL PHARMACOLOGY

Retinoic acid inhibits pancreatic cancer cell migration and EMT through the downregulation of IL-6 in cancer associated fibroblast cells

(2013) Jian Guan et al.   CANCER LETTERS

Epithelial-to-Mesenchymal Transition and Autophagy Induction in Breast Carcinoma Promote Escape from T-cell-Mediated Lysis

(2013) I. Akalay et al.   CANCER RESEARCH

Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer

(2013) Ying Ma et al.   CANCER RESEARCH

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

(2013) Tomonari Kinoshita et al.   CANCER SCIENCE

Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

(2013) Mercedes Herrera et al.   CANCER SCIENCE

Proteome Profiling of Cancer-Associated Fibroblasts Identifies Novel Proinflammatory Signatures and Prognostic Markers for Colorectal Cancer

(2013) S. Torres et al.   CLINICAL CANCER RESEARCH

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells

(2013) Petra C Schuberth et al.   Journal of Translational Medicine

Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity

(2013) Tuanjie Li et al.   MEDICAL ONCOLOGY

Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma

(2013) Sunitha Kakarla et al.   MOLECULAR THERAPY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression

(2013) G Comito et al.   ONCOGENE

Arginase II Expressed in Cancer-Associated Fibroblasts Indicates Tissue Hypoxia and Predicts Poor Outcome in Patients with Pancreatic Cancer

(2013) Yoshinori Ino et al.   PLoS One

Lung Collagens Perpetuate Pulmonary Fibrosis via CD204 and M2 Macrophage Activation

(2013) Mirjam Stahl et al.   PLoS One

Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

(2013) C. Feig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of macrophage phenotype by cell shape

(2013) F. Y. McWhorter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Cancer associated fibroblasts’ – more than meets the eye

(2013) Shalom Madar et al.   TRENDS IN MOLECULAR MEDICINE

Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity

(2013) L.-C. S. Wang et al.   Cancer Immunology Research

The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment

(2012) Jae Hak Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells

(2012) Zu-Yau Lin et al.   BIOMEDICINE & PHARMACOTHERAPY

Stromal fibroblasts synergize with hypoxic oxidative stress to enhance melanoma aggressiveness

(2012) Giuseppina Comito et al.   CANCER LETTERS

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo

(2012) S. Vicent et al.   CANCER RESEARCH

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Oncogenic BRAF(V600E) Promotes Stromal Cell-Mediated Immunosuppression Via Induction of Interleukin-1 in Melanoma

(2012) J. S. Khalili et al.   CLINICAL CANCER RESEARCH

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance

(2012) Nobuyuki Fujii et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The role of promoter hypermethylation in fibroblast activation and fibrogenesis

(2012) Elisabeth M Zeisberg et al.   JOURNAL OF PATHOLOGY

The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

(2012) Mert Erkan et al.   Nature Reviews Gastroenterology & Hepatology

Origins of the Tumor Microenvironment: Quantitative Assessment of Adipose-Derived and Bone Marrow–Derived Stroma

(2012) Shannon Kidd et al.   PLoS One

Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression

(2012) Astrid De Boeck et al.   PROTEOMICS

A new paradigm for mechanobiological mechanisms in tumor metastasis

(2012) Peter A. Torzilli et al.   SEMINARS IN CANCER BIOLOGY

Comparative proteomic analysis of secreted proteins from nasopharyngeal carcinoma-associated stromal fibroblasts and normal fibroblasts

(2012) SHENGLEI GE et al.   Experimental and Therapeutic Medicine

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix

(2012) Hélène Salmon et al.   OncoImmunology

FSP1+ Fibroblasts Promote Skin Carcinogenesis by Maintaining MCP-1-Mediated Macrophage Infiltration and Chronic Inflammation

(2011) Jinhua Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the  c cytokines and TGF- 1

(2011) Y. P. Park et al.   BLOOD

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

(2011) Lucia De Monte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor α1 (IL13Rα1)

(2010) Rocio T. Martinez-Nunez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal Functional Modulation of the Activation of T Lymphocytes and Fibroblasts Derived from Human Solid Tumors

(2010) J. L. Barnas et al.   JOURNAL OF IMMUNOLOGY

CD90/THY1 is overexpressed in prostate cancer-associated fibroblasts and could serve as a cancer biomarker

(2010) Lawrence D True et al.   MODERN PATHOLOGY

Mast Cells Mobilize Myeloid-Derived Suppressor Cells and Treg Cells in Tumor Microenvironment via IL-17 Pathway in Murine Hepatocarcinoma Model

(2010) Zhuoshun Yang et al.   PLoS One

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice

(2009) Jeon-OK Moon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Opposing Effects of TGF-β and IL-15 Cytokines Control the Number of Short-Lived Effector CD8+ T Cells

(2009) Shomyseh Sanjabi et al.   IMMUNITY

Cancer Associated Fibroblasts Promote Tumor Growth and Metastasis by Modulating the Tumor Immune Microenvironment in a 4T1 Murine Breast Cancer Model

(2009) Debbie Liao et al.   PLoS One

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

(2009) M. Balsamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune surveillance of human cancer: if the cytotoxic T-lymphocytes play the music, does the tumoral system call the tune?

(2009) A. Hamaï et al.   TISSUE ANTIGENS

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

PD-1 Ligand Expression by Human Colonic Myofibroblasts/Fibroblasts Regulates CD4+ T-Cell Activity

(2008) Irina V. Pinchuk et al.   GASTROENTEROLOGY

How tumours escape mass destruction

(2008) T J Stewart et al.   ONCOGENE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology