Using the “reverse Warburg effect” to identify high-risk breast cancer patients

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

(2012) Barbara Chiavarina et al.   CANCER BIOLOGY & THERAPY

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

(2012) Ying-Hui Ko et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression in malignant melanoma metastases predicts poor survival

(2012) Karen N. Wu et al.   CELL CYCLE

Energy transfer in "parasitic" cancer metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

(2012) Adam Ertel et al.   CELL CYCLE

Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

(2012) Ubaldo E. Martinez-Outschoorn et al.   Cell Metabolism

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

(2011) Stephanos Pavlides et al.   ANTIOXIDANTS & REDOX SIGNALING

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

(2011) Nelma Pértega-Gomes et al.   BMC CANCER

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells

(2011) Ubaldo E. Martinez-Outschoorn et al.   CANCER BIOLOGY & THERAPY

Prognostic significance of tumor/stromal caveolin-1 expression in breast cancer patients

(2011) Niansong Qian et al.   CANCER SCIENCE

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Understanding the metabolic basis of drug resistance

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Accelerated aging in the tumor microenvironment

(2011) Michael P Lisanti et al.   CELL CYCLE

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth

(2011) Renee M. Balliet et al.   CELL CYCLE

Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis

(2011) Michael P Lisanti et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

(2011) Ja Seung Koo et al.   TUMOR BIOLOGY

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

The reverse Warburg Effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Role of glutamate in neuron-glia metabolic coupling

(2009) Pierre J Magistretti   AMERICAN JOURNAL OF CLINICAL NUTRITION

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7–10

(2009) Matthew J. Ovens et al.   BIOCHEMICAL JOURNAL

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE