Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer

Insulin promotes proliferation and fibrosing responses in activated pancreatic stellate cells

(2016) Jiayue Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors

(2016) Lucy Ireland et al.   CANCER RESEARCH

Heterogeneous Stromal Signaling within the Tumor Microenvironment Controls the Metastasis of Pancreatic Cancer

(2016) Agnieszka A. Rucki et al.   CANCER RESEARCH

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

(2016) Christopher J. Tape et al.   CELL

Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma

(2016) Katarzyna Jakubowska et al.   DISEASE MARKERS

Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation

(2016) Ivan Achel Valdez et al.   Cell Reports

Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia

(2016) Toshiki Hirakawa et al.   PLoS One

A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial†

(2015) C. S. Fuchs et al.   ANNALS OF ONCOLOGY

Phase I study of combination of pasireotide LAR + gemcitabine in locally advanced or metastatic pancreatic cancer

(2015) Yaman Suleiman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Conditionally immortalized human pancreatic stellate cell lines demonstrate enhanced proliferation and migration in response to IGF-I

(2015) Ann H. Rosendahl et al.   EXPERIMENTAL CELL RESEARCH

Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass

(2015) Jose Cordoba-Chacon et al.   GROWTH HORMONE & IGF RESEARCH

Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study

(2015) Guido Carpino et al.   JOURNAL OF ANATOMY

Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage

(2015) Alba Casellas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling

(2015) Oscar Escribano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activated pancreatic stellate cells can impair pancreatic islet function in mice

(2015) Guangxiang Zang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies

(2015) Varsha P. Brahmkhatri et al.   Biomed Research International

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWO

(2014) Philip A. Philip et al.   CANCER

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Low Circulating Levels of IGF-1 in Healthy Adults Are Associated With Reduced β-Cell Function, Increased Intramyocellular Lipid, and Enhanced Fat Utilization During Fasting

(2014) Ajay Thankamony et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Inflammatory Chemokine CCL5 and Cancer Progression

(2014) Donatella Aldinucci et al.   MEDIATORS OF INFLAMMATION

Anticancer activity of the type I insulin-like growth factor receptor antagonist, ganitumab, in combination with the death receptor 5 agonist, conatumumab

(2014) Josep Tabernero et al.   Targeted Oncology

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Diabetes, pancreatic cancer, and metformin therapy

(2014) Jun Gong et al.   Frontiers in Physiology

Pancreatic stellate cells reduce insulin expression and induce apoptosis in pancreatic β-cells

(2013) Kazuhiro Kikuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IGF-1 receptor and IGF binding protein-3 might predict prognosis of patients with resectable pancreatic cancer

(2013) Toshiki Hirakawa et al.   BMC CANCER

Insulin-Like Growth Factor 1 Receptor Promotes the Growth and Chemoresistance of Pancreatic Cancer

(2013) Xiaodong Tian et al.   DIGESTIVE DISEASES AND SCIENCES

The role of insulin and IGF system in pancreatic cancer

(2013) Marija Trajkovic-Arsic et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pharmacodynamic and Antineoplastic Activity of BI 836845, a Fully Human IGF Ligand-Neutralizing Antibody, and Mechanistic Rationale for Combination with Rapamycin

(2013) K. Friedbichler et al.   MOLECULAR CANCER THERAPEUTICS

MM-141, an IGF-IR- and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

(2013) J. B. Fitzgerald et al.   MOLECULAR CANCER THERAPEUTICS

A randomized, placebo-controlled phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer

(2012) H. L. Kindler et al.   ANNALS OF ONCOLOGY

Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

(2012) S Rohrmann et al.   BRITISH JOURNAL OF CANCER

Diabetes and cancer I: risk, survival, and implications for screening

(2012) Adedayo A. Onitilo et al.   CANCER CAUSES & CONTROL

Serum CA19-9, cathepsin D, and matrix metalloproteinase-7 as a diagnostic panel for pancreatic ductal adenocarcinoma

(2012) Hyung-Doo Park et al.   PROTEOMICS

Age-dependent reduction of the PI3K regulatory subunit p85α suppresses pancreatic acinar cell proliferation

(2011) Hitoshi Takahashi et al.   AGING CELL

Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

(2011) Matias E. Valsecchi et al.   CANCER

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion

(2011) K. Hoa Nguyen et al.   ENDOCRINOLOGY

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Signaling Cross Talk between Growth Hormone (GH) and Insulin-Like Growth Factor-I (IGF-I) in Pancreatic Islet β-Cells

(2011) Fanxin Ma et al.   MOLECULAR ENDOCRINOLOGY

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The islet-acinar axis of the pancreas: more than just insulin

(2010) Savio G. Barreto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nerve Growth Factor and Artemin Are Paracrine Mediators of Pancreatic Neuropathy in Pancreatic Adenocarcinoma

(2010) Güralp O. Ceyhan et al.   ANNALS OF SURGERY

Serum IGF-I, IGF-II, IGFBP-3, and IGF-I/IGFBP-3 Molar Ratio and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

(2010) J. B. Douglas et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Phase III Study Comparing Gemcitabine Plus Cetuximab Versus Gemcitabine in Patients With Advanced Pancreatic Adenocarcinoma: Southwest Oncology Group–Directed Intergroup Trial S0205

(2010) Philip A. Philip et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiplex N-terminome Analysis of MMP-2 and MMP-9 Substrate Degradomes by iTRAQ-TAILS Quantitative Proteomics

(2010) Anna Prudova et al.   MOLECULAR & CELLULAR PROTEOMICS

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Pancreatic cancer cells activate CCL5 expression in mesenchymal stromal cells through the insulin-like growth factor-I pathway

(2009) Hideki Makinoshima et al.   FEBS LETTERS

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

(2008) J. Agudo et al.   DIABETOLOGIA