Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway

Tumor Microenvironment, Metabolism, and Immunotherapy

(2020) Ralph J. DeBerardinis   NEW ENGLAND JOURNAL OF MEDICINE

ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma

(2020) Hailong Sheng et al.   Journal for ImmunoTherapy of Cancer

Inhibition of ATM increases interferon signaling and sensitizes pancreatic cancer to immune checkpoint blockade therapy

(2019) Qiang Zhang et al.   CANCER RESEARCH

Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E Mutant Thyroid Cancer Cells by Constraining DNA Double-strand Break Repair

(2019) Ryan Robb et al.   CLINICAL CANCER RESEARCH

Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review

(2019) Barbora Peltanova et al.   Molecular Cancer

Prognosis and modulation mechanisms of COMMD6 in human tumours based on expression profiling and comprehensive bioinformatics analysis

(2019) Mi Yang et al.   BRITISH JOURNAL OF CANCER

Targeting the Immune Microenvironment in the Treatment of Head and Neck Squamous Cell Carcinoma

(2019) Hui-Ching Wang et al.   Frontiers in Oncology

Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression

(2018) Dhruv Kumar et al.   CANCER RESEARCH

Development and validation of a gene expression-based signature to predict distant metastasis in locoregionally advanced nasopharyngeal carcinoma: a retrospective, multicentre, cohort study

(2018) Xin-Ran Tang et al.   LANCET ONCOLOGY

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

SOX2 regulates radioresistance in cervical cancer via the hedgehog signaling pathway

(2018) Chunxian Huang et al.   GYNECOLOGIC ONCOLOGY

Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma

(2018) Hajime Kashima et al.   INTERNATIONAL JOURNAL OF CANCER

Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells

(2017) Neng Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

(2017) Julien Racle et al.   eLife

Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy

(2017) Yongbin Wang et al.   EBioMedicine

PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts

(2016) Mogher Khamaisi et al.   JOURNAL OF CLINICAL INVESTIGATION

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

(2016) Tanguy Y Seiwert et al.   LANCET ONCOLOGY

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

(2016) Robert L. Ferris et al.   NEW ENGLAND JOURNAL OF MEDICINE

bFGF Promotes Migration and Induces Cancer-Associated Fibroblast Differentiation of Mouse Bone Mesenchymal Stem Cells to Promote Tumor Growth

(2016) Xue Yang et al.   STEM CELLS AND DEVELOPMENT

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

(2016) Alexandra Avgustinova et al.   Nature Communications

Suicide Gene-Engineered Stromal Cells Reveal a Dynamic Regulation of Cancer Metastasis

(2016) Keyue Shen et al.   Scientific Reports

MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

(2015) Adriana Estrada-Bernal et al.   CELL CYCLE

miR-101 sensitizes human nasopharyngeal carcinoma cells to radiation by targeting stathmin 1

(2015) QUANQUAN SUN et al.   Molecular Medicine Reports

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Tranilast: A review of its therapeutic applications

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

Nimotuzumab enhances radiation sensitivity of NSCLC H292 cells in vitro by blocking epidermal growth factor receptor nuclear translocation and inhibiting radiation-induced DNA damage repair

(2015) Kai Teng et al.   OncoTargets and Therapy

Hematopoietic Stem Cell–Derived Cancer–Associated Fibroblasts Are Novel Contributors to the Pro-Tumorigenic Microenvironment

(2015) Lindsay T. McDonald et al.   NEOPLASIA

Soyasaponins Can Blunt Inflammation by Inhibiting the Reactive Oxygen Species-Mediated Activation of PI3K/Akt/NF-kB Pathway

(2014) Longying Zha et al.   PLoS One

Crosstalk with Cancer-Associated Fibroblasts Increases the Growth and Radiation Survival of Cervical Cancer Cells

(2014) Tang-Yuan Chu et al.   RADIATION RESEARCH

Tranilast Inhibits the Function of Cancer-Associated Fibroblasts Responsible for the Induction of Immune Suppressor Cell Types

(2014) Y. Ohshio et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

TGF-beta in CAF-mediated tumor growth and metastasis

(2014) A. Calon et al.   SEMINARS IN CANCER BIOLOGY

Prognostic model for survival of local recurrent nasopharyngeal carcinoma with intensity-modulated radiotherapy

(2013) Y-M Tian et al.   BRITISH JOURNAL OF CANCER

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

Cyclin D1 overexpression perturbs DNA replication and induces replication-associated DNA double-strand breaks in acquired radioresistant cells

(2013) Tsutomu Shimura et al.   CELL CYCLE

MicroRNA-324-3p regulates nasopharyngeal carcinoma radioresistance by directly targeting WNT2B

(2013) Guo Li et al.   EUROPEAN JOURNAL OF CANCER

Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor-associated fibroblasts in preclinical models

(2013) Sarah Elizabeth Wheeler et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Cancer-Associated Fibroblasts from Hepatocellular Carcinoma Promote Malignant Cell Proliferation by HGF Secretion

(2013) Chang-Chang Jia et al.   PLoS One

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells

(2012) W.-J. Wang et al.   CANCER RESEARCH

Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer

(2012) Q.-T. Le et al.   CLINICAL CANCER RESEARCH

Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through  1-Integrin Signaling

(2011) T. S. Mantoni et al.   CANCER RESEARCH

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

(2011) Jonathan W. Wojtkowiak et al.   MOLECULAR PHARMACEUTICS

Focus on histone variant H2AX: To be or not to be

(2010) Jingsong Yuan et al.   FEBS LETTERS

Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer

(2010) Ibrahim O. Bello et al.   ORAL ONCOLOGY