Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response

The Role of Tocotrienol in Arthritis Management—A Scoping Review of Literature

(2023) Hashwin Singh Tejpal Singh et al.   Pharmaceuticals

Protein folding in vitro and in the cell: From a solitary journey to a team effort

(2022) Miranda F. Mecha et al.   BIOPHYSICAL CHEMISTRY

A Redox-Silent Analogue of Tocotrienol May Break the Homeostasis of Proteasomes in Human Malignant Mesothelioma Cells by Inhibiting STAT3 and NRF1

(2022) Kyota Ishii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revisiting the therapeutic potential of tocotrienol

(2022) Ranmali Ranasinghe et al.   BIOFACTORS

Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells

(2022) Kok-Lun Pang et al.   Nutrients

Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol

(2022) Yusuke Nakatani et al.   Journal of Physical Chemistry Letters

Involvement of miR-190b in Xbp1 mRNA Splicing upon Tocotrienol Treatment

(2021) Roberto Ambra et al.   MOLECULES

MicroRNA and ER stress in cancer

(2021) Taewan Kim et al.   SEMINARS IN CANCER BIOLOGY

Genotoxicity of radiofrequency electromagnetic fields: Protocol for a systematic review of in vitro studies

(2021) Stefania Romeo et al.   ENVIRONMENT INTERNATIONAL

Glucose deprivation‐induced endoplasmic reticulum stress response plays a pivotal role in enhancement of TRAIL cytotoxicity

(2021) Kalishwaralal Kalimuthu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ca2+ overload- and ROS-associated mitochondrial dysfunction contributes to δ-tocotrienol-mediated paraptosis in melanoma cells

(2021) Michela Raimondi et al.   APOPTOSIS

miRNA-mRNA Regulatory Network Reveals miRNAs in HCT116 in Response to Folic Acid Deficiency via Regulating Vital Genes of Endoplasmic Reticulum Stress Pathway

(2021) Lin Lu et al.   Biomed Research International

Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?

(2021) Kacper Szewczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Swainsonine Triggers Paraptosis via ER Stress and MAPK Signaling Pathway in Rat Primary Renal Tubular Epithelial Cells

(2021) Shuai Wang et al.   Frontiers in Pharmacology

Tocotrienols as an Anti-Breast Cancer Agent

(2021) Madison Trujillo et al.   Antioxidants

Protective Effects of Annatto Tocotrienol and Palm Tocotrienol-Rich Fraction on Chondrocytes Exposed to Monosodium Iodoacetate

(2021) Kok-Lun Pang et al.   Applied Sciences-Basel

miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells

(2020) Fanhua Kong et al.   Photodiagnosis and Photodynamic Therapy

Annatto-Derived Tocotrienol Promotes Mineralization of MC3T3-E1 Cells by Enhancing BMP-2 Protein Expression via Inhibiting RhoA Activation and HMG-CoA Reductase Gene Expression

(2020) Wan Nuraini Wan Hasan et al.   Drug Design Development and Therapy

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

(2020) Sok Kuan Wong et al.   Nutrients

Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway

(2020) Maya Idriss et al.   Biomolecules

Crosstalk between endoplasmic reticulum stress and oxidative stress: Focus on protein disulfide isomerase and endoplasmic reticulum oxidase 1

(2020) Paul Victor et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

(2019) Hai Hu et al.   Frontiers in Immunology

The Role of Tocotrienol in Protecting Against Metabolic Diseases

(2019) Kok-Lun Pang et al.   MOLECULES

Role of Endoplasmic Reticulum Stress in the Anticancer Activity of Natural Compounds

(2019) Patrizia Limonta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements

(2019) Vaishali Aggarwal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

δ‐Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells

(2019) Fabrizio Fontana et al.   CELL PROLIFERATION

γ-Tocotrienol Suppression of the Warburg Effect Is Mediated by AMPK Activation in Human Breast Cancer Cells

(2019) Venkateshwara Dronamraju et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

GRP78: A cell's response to stress

(2019) Ibrahim M. Ibrahim et al.   LIFE SCIENCES

Transcriptome analysis reveals the molecular mechanisms of combined gamma-tocotrienol and hydroxychavicol in preventing the proliferation of 1321N1, SW1783, and LN18 glioma cancer cells

(2019) Amirah Abdul Rahman et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems

(2019) Daria Sicari et al.   FEBS Journal

Advancing the Role of Gamma-Tocotrienol as Proteasomes Inhibitor: A Quantitative Proteomic Analysis of MDA-MB-231 Human Breast Cancer Cells

(2019) Premdass Ramdas et al.   Biomolecules

Modulation of Ki67 and myogenic regulatory factor expression by tocotrienol-rich fraction ameliorates myogenic program of senescent human myoblasts

(2019) Chun Min Tan et al.   Archives of Medical Science

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities

(2018) Nardev Ramanathan et al.   Nutrition & Metabolism

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

(2018) Wan Nuraini Wan Hasan et al.   Drug Design Development and Therapy

Abstract 1255: Delta-tocopherol induced endoplasmic reticulum stress causes autophagic degradation of ER and cell death in bladder cancer models

(2018) Christopher A. Blair et al.   CANCER RESEARCH

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

Cellular Uptake and Bioavailability of Tocotrienol-Rich Fraction in SIRT1-Inhibited Human Diploid Fibroblasts

(2018) Faizul Jaafar et al.   Scientific Reports

Vitamin E δ-tocotrienol inhibits TNF-α-stimulated NF-κB activation by up-regulation of anti-inflammatory A20 via modulation of sphingolipid including elevation of intracellular dihydroceramides

(2018) Chao Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autosomal recessive cone-rod dystrophy can be caused by mutations in the ATF6 gene

(2017) Anna Skorczyk-Werner et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Nexus Implicated in Bowel Disease Pathophysiology

(2017) Wai Chong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the sarco/endoplasmic reticulum (ER) Ca2+-ATPase by thapsigargin analogs induces cell death via ER Ca2+depletion and the unfolded protein response

(2017) Pankaj Sehgal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment

(2017) Yumi Jang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Combination Effect of δ-Tocotrienol and γ-Tocopherol on Prostate Cancer Cell Growth

(2017) Chiaki SATO et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Tocotrienol-Rich Fraction Ameliorates Antioxidant Defense Mechanisms and Improves Replicative Senescence-Associated Oxidative Stress in Human Myoblasts

(2017) Shy Cian Khor et al.   Oxidative Medicine and Cellular Longevity

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

(2016) Raffaella Comitato et al.   Genes and Nutrition

Endoplasmic Reticulum Stress and Associated ROS

(2016) Hafiz Zeeshan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts

(2016) Shy Cian Khor et al.   PLoS One

Vitamin E δ-tocotrienol triggers endoplasmic reticulum stress-mediated apoptosis in human melanoma cells

(2016) Marina Montagnani Marelli et al.   Scientific Reports

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

(2016) Raffaella Comitato et al.   Genes and Nutrition

γ-Tocotrienol-induced endoplasmic reticulum stress and autophagy act concurrently to promote breast cancer cell death

(2015) Roshan V. Tiwari et al.   Biochemistry and Cell Biology

Calcium and ROS: A mutual interplay

(2015) Agnes Görlach et al.   Redox Biology

Bioavailability of tocotrienols: evidence in human studies

(2014) Ju-Yen Fu et al.   Nutrition & Metabolism

Induction of ER stress-mediated apoptosis by ceramide via disruption of ER Ca2+ homeostasis in human adenoid cystic carcinoma cells

(2014) Zhe Liu et al.   Cell and Bioscience

Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

(2013) Guligena Tuerdi et al.   CANCER LETTERS

γ-Tocotrienol Induces Paraptosis-Like Cell Death in Human Colon Carcinoma SW620 Cells

(2013) Jing-Shu Zhang et al.   PLoS One

ERO1α-dependent endoplasmic reticulum–mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1)

(2013) M Seervi et al.   Cell Death & Disease

Abstract 190: Targeting ceramide and endoplasmic reticulum-stress in vitamin E induced apoptosis in human breast cancer cells

(2012) Archana Gopalan et al.   CANCER RESEARCH

Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells

(2012) Archana Gopalan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Distinct roles of different forms of vitamin E in DHA-induced apoptosis in triple-negative breast cancer cells

(2012) Ailian Xiong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury

(2012) Sue-Mian Then et al.   Nutrition & Metabolism

miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer

(2012) S-F Su et al.   ONCOGENE

ER Stress Negatively Modulates the Expression of the miR-199a/214 Cluster to Regulates Tumor Survival and Progression in Human Hepatocellular Cancer

(2012) Quanlu Duan et al.   PLoS One

Tocotrienols and breast cancer: the evidence to date

(2011) Kalanithi Nesaretnam et al.   Genes and Nutrition

Gamma-tocotrienol induces apoptosis and autophagy in prostate cancer cells by increasing intracellular dihydrosphingosine and dihydroceramide

(2011) Qing Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

Tocotrienol-Rich Fraction Prevents Cell Cycle Arrest and Elongates Telomere Length in Senescent Human Diploid Fibroblasts

(2011) Suzana Makpol et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells

(2011) Dorrelyn Patacsil et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A paraptosis-like cell death induced by δ-tocotrienol in human colon carcinoma SW620 cells is associated with the suppression of the Wnt signaling pathway

(2011) Jing-Shu Zhang et al.   TOXICOLOGY

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

(2010) Bharat B. Aggarwal et al.   BIOCHEMICAL PHARMACOLOGY

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells

(2010) Xiaoli Huang et al.   CANCER LETTERS

TRB3 Function in Cardiac Endoplasmic Reticulum Stress

(2010) Joan Avery et al.   CIRCULATION RESEARCH

Role of Endoplasmic Reticulum Stress in α-TEA Mediated TRAIL/DR5 Death Receptor Dependent Apoptosis

(2010) Richa Tiwary et al.   PLoS One

Endoplasmic reticulum stress mediates γ-tocotrienol-induced apoptosis in mammary tumor cells

(2009) Vikram B. Wali et al.   APOPTOSIS

Design and preliminary structure–activity relationship of redox-silent semisynthetic tocotrienol analogues as inhibitors for breast cancer proliferation and invasion

(2009) Ahmed Y. Elnagar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Suppression in Mevalonate Synthesis Mediates Antitumor Effects of Combined Statin and γ-Tocotrienol Treatment

(2009) Vikram B. Wali et al.   LIPIDS

Induction of Caspase-Independent Programmed Cell Death by Vitamin E Natural Homologs and Synthetic Derivatives

(2009) Constantina Constantinou et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD