Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway

Himachalol induces apoptosis in B16-F10 murine melanoma cells and protects against skin carcinogenesis

(2020) Wassim Shebaby et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro

(2019) Sonia Abou Najem et al.   Current Molecular Pharmacology

Molecular Mechanisms of Action of Tocotrienols in Cancer: Recent Trends and Advancements

(2019) Vaishali Aggarwal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Single hormone receptor-positive breast cancer patients experienced poor survival outcomes: a systematic review and meta-analysis

(2019) N. Wu et al.   Clinical & Translational Oncology

Annona cherimola Seed Extract Activates Extrinsic and Intrinsic Apoptotic Pathways in Leukemic Cells

(2019) Tony Haykal et al.   Toxins

The Vitamin E Derivative Gamma Tocotrienol Promotes Anti-Tumor Effects in Acute Myeloid Leukemia Cell Lines

(2019) Ghanem et al.   Nutrients

In Vitro and In Vivo Evaluation of the Anticancer and Anti-inflammatory Activities of 2-Himachelen-7-ol isolated from Cedrus Libani

(2019) Andree Elias et al.   Scientific Reports

Adjuvant Epigenetic Therapy of Decitabine and Suberoylanilide Hydroxamic Acid Exerts Anti-Neoplastic Effects in Acute Myeloid Leukemia Cells

(2019) Sonia Abou Najem et al.   Cells

The pro-apoptotic effect of a Terpene-rich Annona cherimola leaf extract on leukemic cell lines

(2019) Carl Ammoury et al.   BMC Complementary and Alternative Medicine

Tocotrienols: The promising analogues of vitamin E for cancer therapeutics

(2018) Bethsebie Lalduhsaki Sailo et al.   PHARMACOLOGICAL RESEARCH

Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway

(2018) Mohammad Hassan Hodroj et al.   Cancer Management and Research

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets

(2018) Marina Montagnani Marelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Challenges and Opportunities of Nanotechnology as Delivery Platform for Tocotrienols in Cancer Therapy

(2018) Geetha Maniam et al.   Frontiers in Pharmacology

Biochemical characterization, anti-inflammatory properties and ulcerogenic traits of some cold-pressed oils in experimental animals

(2017) Faten M. Ibrahim et al.   PHARMACEUTICAL BIOLOGY

Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT).

(2017) Eric A. Klein et al.   JOURNAL OF CLINICAL ONCOLOGY

γ-Tocotrienol-induced endoplasmic reticulum stress and autophagy act concurrently to promote breast cancer cell death

(2015) Roshan V. Tiwari et al.   Biochemistry and Cell Biology

Antioxidant activities of tocopherols/tocotrienols and lipophilic antioxidant capacity of wheat, vegetable oils, milk and milk cream by using photochemiluminescence

(2015) Jasmin Karmowski et al.   FOOD CHEMISTRY

Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines

(2014) Su-Wen Lim et al.   BIOMEDICINE & PHARMACOTHERAPY

Tocotrienol-Rich Fraction, [6]-Gingerol and Epigallocatechin Gallate Inhibit Proliferation and Induce Apoptosis of Glioma Cancer Cells

(2014) Amirah Rahman et al.   MOLECULES

Pharmacological potential of tocotrienols: a review

(2014) Haseeb Ahsan et al.   Nutrition & Metabolism

Tocotrienols Target PI3K/Akt Signaling in Anti-Breast Cancer Therapy

(2013) Paul Sylvester et al.   Anti-Cancer Agents in Medicinal Chemistry

Potential role of tocotrienols in the treatment and prevention of breast cancer

(2013) Paul W. Sylvester et al.   BIOFACTORS

Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity

(2013) R. Loganathan et al.   CELL PROLIFERATION

GSK3β and cyclin D1 expression predicts outcome in early breast cancer patients

(2012) Mary Anne Quintayo et al.   BREAST CANCER RESEARCH AND TREATMENT

Cancer gene therapy targeting cellular apoptosis machinery

(2012) Lin-Tao Jia et al.   CANCER TREATMENT REVIEWS

Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients

(2012) Viren Patel et al.   JOURNAL OF NUTRITION

Tocotrienols inhibit AKT and ERK activation and suppress pancreatic cancer cell proliferation by suppressing the ErbB2 pathway

(2011) Sonyo Shin-Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tocotrienols and breast cancer: the evidence to date

(2011) Kalanithi Nesaretnam et al.   Genes and Nutrition

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells

(2011) Dorrelyn Patacsil et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expression

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases

(2010) Bharat B. Aggarwal et al.   BIOCHEMICAL PHARMACOLOGY

Present trends in vitamin E research

(2010) Francesco Galli et al.   BIOFACTORS

Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling

(2010) Sook Kyung Park et al.   BREAST CANCER RESEARCH AND TREATMENT

γ- and δ-tocotrienols exert a more potent anticancer effect than α-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression

(2010) Elisa Pierpaoli et al.   LIFE SCIENCES

In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma

(2010) Lars Müller et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

(2010) Fiona M. Blows et al.   PLOS MEDICINE

Endoplasmic reticulum stress mediates γ-tocotrienol-induced apoptosis in mammary tumor cells

(2009) Vikram B. Wali et al.   APOPTOSIS

Synergistic anticancer effects of combined γ-tocotrienol and celecoxib treatment are associated with suppression in Akt and NFκB signaling

(2009) Amit B. Shirode et al.   BIOMEDICINE & PHARMACOTHERAPY

Anti-proliferative effects of γ-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progression

(2009) G. V. Samant et al.   CELL PROLIFERATION

Anticancer actions of natural and synthetic vitamin E forms: RRR-α-tocopherol blocks the anticancer actions of γ-tocopherol

(2009) Weiping Yu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Inhibition of proliferation and induction of apoptosis by γ-tocotrienol in human colon carcinoma HT-29 cells

(2009) Wei-Li Xu et al.   NUTRITION

Evidence ofγ-Tocotrienol as an Apoptosis-Inducing, Invasion-Suppressing, and Chemotherapy Drug-Sensitizing Agent in Human Melanoma Cells

(2009) Piek Ngoh Chang et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

γ-Tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways

(2008) W N Yap et al.   BRITISH JOURNAL OF CANCER

Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

(2008) Katarina Nikolic et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Tocotrienol Inhibits Secretion of Angiogenic Factors from Human Colorectal Adenocarcinoma Cells by Suppressing Hypoxia-Inducible Factor-1α

(2008) Akira Shibata et al.   JOURNAL OF NUTRITION

Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases

(2008) Q. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA