Article
Toxicology
Feby Savira, Ruth Magaye, Carmen Scullino, Bernard L. Flynn, Stuart M. Pitson, Dovile Anderson, Darren J. Creek, Yue Hua, Xin Xiong, Li Huang, Danny Liew, Christopher Reid, David Kaye, Andrew R. Kompa, Bing Hui Wang
Summary: This study assessed the effects of Des1 inhibition on PBUT-induced cardiac and renal effects, showing that Des1 inhibition attenuated negative effects on heart and kidney cells induced by PBUTs, such as hypertrophy and collagen synthesis, by modulating NF-κB signaling and reducing gene expression levels.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Mariam Alsanafi, Ryan D. R. Brown, Jeongah Oh, David R. Adams, Federico Torta, Nigel J. Pyne, Susan Pyne
Summary: Degs1 functions both as an 'inducer' and 'rectifier' of apoptosis in response to chemical cellular stress, determining cytotoxicity through a dynamic balance that depends on the nature of the stress.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Nutrition & Dietetics
Kok-Lun Pang, Lian-Chee Foong, Norzana Abd Ghafar, Ima Nirwana Soelaiman, Jia Xian Law, Lek Mun Leong, Kok-Yong Chin
Summary: This study investigated the anticancer properties of annatto tocotrienol (AnTT), gamma-tocotrienol (gamma-T3), and delta-tocotrienol (delta-T3) on chondrosarcoma cells. The results showed that these tocotrienols induced G1 arrest and apoptosis in the cells, as well as caused cytoplasmic vacuolation. Transcriptomic analysis revealed upregulated signaling pathways related to endoplasmic reticulum stress, autophagy, and transcription. Several cell proliferation and cancer-related pathways, such as Hippo and Wnt signaling pathways, were also downregulated. Further research is needed to confirm the effectiveness of these tocotrienols as adjuvant therapy for chondrosarcoma.
Article
Cell Biology
Pau Munoz-Guardiola, Josefina Casas, Elisabet Megias-Roda, Sonia Sole, Hector Perez-Montoyo, Marc Yeste-Velasco, Tatiana Erazo, Nora Dieguez-Martinez, Sergio Espinosa-Gil, Cristina Munoz-Pinedo, Guillermo Yoldi, Jose L. Abad, Miguel F. Segura, Teresa Moran, Margarita Romeo, Joaquim Bosch-Barrera, Ana Oaknin, Jose Alfon, Carles Domenech, Gemma Fabrias, Guillermo Velasco, Jose M. Lizcano
Summary: ABTL0812 induces cytotoxic autophagy in cancer cells by increasing cellular long-chain dihydroceramides and impairing DEGS1 activity, leading to sustained ER stress and activation of the unfolded protein response (UPR). This discovery suggests that manipulation of dihydroceramide levels could be a new therapeutic strategy for targeting cancer.
Article
Biochemistry & Molecular Biology
Nuria Bielsa, Mireia Casasampere, Jose Luis Abad, Carlos Enrich, Antonio Delgado, Gemma Fabrias, Jose M. Lizcano, Josefina Casas
Summary: This study investigates the mechanism of cytotoxicity induced by the natural sphingolipid Jaspine B in lung adenocarcinoma cells. The findings suggest that Jaspine B can induce cytoplasmic vacuolation and methuosis, and that the activation of AMPK may be involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sina Vakili, Fatemeh Zal, Zohreh Mostafavi-pour, Amir Savardashtaki, Farhad Koohpeyma
Summary: The study demonstrated that quercetin and vitamin E could prevent osteoporosis by regulating the total number of bone cells, possibly through modulating autophagy and apoptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ahlam M. M. Alhusaini, Sara A. A. Alhumaidan, Ghaida M. M. Alharbi, Eman A. A. Alzahrani, WedadS S. Sarawi, Hatun A. A. Alomar, Abeer M. M. Alanazi, Dareen S. S. Mattar, Iman H. H. Hasan
Summary: This study investigated the protective effects of vitamin E and lactobacillus plantarum against mercuric chloride-induced kidney injury. The results showed that both vitamin E and lactobacillus plantarum provided protection against kidney damage by regulating autophagy and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Guo, Cuiyu Zhang, Panpan Feng, Mingying Li, Xia Wang, Yuan Xia, Dawei Chen, Jingxin Li
Summary: The study found that in colorectal cancer, m6A modification leads to upregulation of DEGS2, thereby suppressing ceramide synthesis and affecting lipid metabolism regulation. DEGS2 plays a role in proliferation, invasion, and metastasis of CRC cells.
Article
Multidisciplinary Sciences
Perng Yang Puah, Dexter Jiunn Herng Lee, Soo Huan Puah, Nik Amin Sahid Nik Lah, Yee Soon Ling, Siat Yee Fong
Summary: In this study, the anticancer effects of a root fraction of Eleusine indica (R-S5-C1-H1) on three cancer cell lines were investigated. The results showed that R-S5-C1-H1 significantly reduced the cell viability of the cancer cells and induced apoptotic cell death. Metabolomic analysis revealed alterations in hydrophobic metabolites, suggesting that modulation of phospholipid synthesis and sphingolipid metabolism may contribute to the anticancer mechanism of R-S5-C1-H1.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Anji Reddy Konda, Malleswari Gelli, Connor Pedersen, Rebecca E. Cahoon, Chunyu Zhang, Toshihiro Obata, Edgar B. Cahoon
Summary: The aim of this study was to increase tocochromanol production in camelina seeds by expressing target genes and enhancing biosynthesis. The results showed that co-expression of HPPD/TyrA and suppression of the HGO gene increased tocochromanol production by 2.5-fold and 1.4-fold, respectively.
METABOLIC ENGINEERING
(2023)
Article
Plant Sciences
Estanislao Burgos, Maria Belen De Luca, Isidore Diouf, Luis A. de Haro, Elise Albert, Christopher Sauvage, Zhao J. Tao, Luisa Bermudez, Ramon Asis, Adriano N. Nesi, Michel Matringe, Claire Brehelin, Thomas Guiraud, Carine Ferrand, Isabelle Atienza, Joana Jorly, Jean P. Mauxion, Pierre Baldet, Alisdair R. Fernie, Leandro Quadrana, Christophe Rothan, Mathilde Causse, Fernando Carrari
Summary: By studying the genetic determinants of tocochromanol accumulation in tomato fruits and genetically engineering their biosynthetic pathway, a total of 25 quantitative trait loci were identified across the genome. By bypassing specific pathway points, the engineered tomatoes showed increased tocopherols and tocotrienols content, indicating a trade-off between VTE and natural variation in chorismate metabolism.
Review
Biochemistry & Molecular Biology
Nur Amira Md Amin, Siti Hamimah Sheikh Abdul Kadir, Akmal Hisyam Arshad, Norhaslinda Abdul Aziz, Nurul Alimah Abdul Nasir, Normala Ab Latip
Summary: Vitamin E has been shown to play a crucial role in female reproductive processes, but its benefits for female fertility and gynecological health are still unclear. This paper summarizes the known effects of vitamin E supplementation on women's gynecological health and reproductive-related diseases, and explores future research directions.
Review
Endocrinology & Metabolism
Floriane Lachkar, Pascal Ferre, Fabienne Foufelle, Alexandra Papaioannou
Summary: Dihydroceramides, previously considered biologically inactive, have been shown in recent studies to play important roles in various biological processes such as cellular stress responses, cell growth, pro-death or pro-survival pathways, hypoxia, and immune responses. Their plasma concentration is related to metabolic diseases and serves as a long-term predictor of type 2 diabetes onset.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
Summary: 24S-OHC and 25OHC induced the same type of cell death in each of the cell types examined, and the inhibitory effect varied depending on the type of cell death for alpha-Toc and alpha-Toc3.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Susana Mesen-Porras, Andrea Rojas-Cespedes, Jose Arturo Molina-Mora, Jose Vega-Baudrit, Francisco Siles, Steve Quiros, Rodrigo Mora-Rodriguez
Summary: Tumor heterogeneity leads to drug resistance in cancer treatment, with sphingolipids playing a crucial role in cell fate and stress signaling. This study analyzed sphingolipid metabolism and autophagic flux in the A549 lung cancer model to study the interactions of chemotherapy drugs. The results showed that combining chemotherapies with autophagy inducers effectively reduced cell viability, but paclitaxel often had antagonistic effects. Further research is needed to identify specific sphingolipids accumulating in autophagosomes.
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)