A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems

Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung

(2019) Maike Thamsen et al.   PLoS One

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress

(2019) Shengchun Xu et al.   Journal of Neuroinflammation

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis

(2019) Eduardo Balsa et al.   MOLECULAR CELL

The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors

(2019) Mohamed Mahameed et al.   Cell Death & Disease

Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6

(2019) Daria Sicari et al.   ONCOGENE

Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α

(2018) Jianchao Zhang et al.   EMBO JOURNAL

Dual IRE1 RNase functions dictate glioblastoma development

(2018) Stéphanie Lhomond et al.   EMBO Molecular Medicine

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

(2018) Chih-Hang Anthony Tang et al.   JOURNAL OF CELL BIOLOGY

Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells

(2018) Kamil Lisek et al.   Oncotarget

New tools for redox biology: From imaging to manipulation

(2017) Dmitry S. Bilan et al.   FREE RADICAL BIOLOGY AND MEDICINE

PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells

(2017) Wangyu Cai et al.   MOLECULAR CANCER THERAPEUTICS

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip

(2017) Alise J. Ponsero et al.   MOLECULAR CELL

Development of a fluorescent reporter system for monitoring ER stress in Chinese hamster ovary cells and its application for therapeutic protein production

(2017) Gargi Roy et al.   PLoS One

Genetically Encoded Fluorescent Indicators for Organellar Calcium Imaging

(2016) Junji Suzuki et al.   BIOPHYSICAL JOURNAL

Development of a stable ERroGFP variant suitable for monitoring redox dynamics in the ER

(2016) J. Hoseki et al.   BIOSCIENCE REPORTS

HERPUD1 protects against oxidative stress-induced apoptosis through downregulation of the inositol 1,4,5-trisphosphate receptor

(2016) Felipe Paredes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes

(2016) Bruce Morgan et al.   Nature Chemical Biology

Simultaneous fluorescence imaging of hydrogen peroxide in mitochondria and endoplasmic reticulum during apoptosis

(2016) Haibin Xiao et al.   Chemical Science

Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

(2016) Ciara M Gallagher et al.   eLife

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

(2015) Edward Avezov et al.   BMC BIOLOGY

Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling

(2015) M. Carrara et al.   EMBO JOURNAL

Cleavage ofBLOC1S1mRNA by IRE1 Is Sequence Specific, Temporally Separate fromXBP1Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

(2015) Michael D. Bright et al.   MOLECULAR AND CELLULAR BIOLOGY

Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status

(2015) Kristin Moore et al.   MOLECULAR BIOLOGY OF THE CELL

Controlling the unfolded protein response-mediated life and death decisions in cancer

(2015) Marion Maurel et al.   SEMINARS IN CANCER BIOLOGY

GADD34-deficient mice develop obesity, nonalcoholic fatty liver disease, hepatic carcinoma and insulin resistance

(2015) Naomi Nishio et al.   Scientific Reports

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling

(2015) Marta Carrara et al.   eLife

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

(2014) Alexander Jais et al.   CELL

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

(2014) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased Expression of Hepatocyte Nuclear Factor 4α (Hnf4α)/MicroRNA-122 (miR-122) Axis in Hepatitis B Virus-associated Hepatocellular Carcinoma Enhances Potential Oncogenic GALNT10 Protein Activity

(2014) Qian Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox controls UPR to control redox

(2014) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Imaging dynamic redox processes with genetically encoded probes

(2014) Daria Ezeriņa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

(2014) Shengyi Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability

(2014) Paul E. Harrington et al.   ACS Medicinal Chemistry Letters

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

(2014) Satoshi Tsunoda et al.   eLife

Detection and quantification of endoplasmic reticulum stress in living cells using the fluorescent compound, Thioflavin T

(2013) Daniel R. Beriault et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Comparative Analysis of the Expression Patterns of UPR-Target Genes Caused by UPR-Inducing Compounds

(2013) Satoko SHINJO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

(2013) Edward Avezov et al.   JOURNAL OF CELL BIOLOGY

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

Pharmacological brake-release of mRNA translation enhances cognitive memory

(2013) Carmela Sidrauski et al.   eLife

Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise

(2013) Julia Birk et al.   Frontiers in Genetics

Blockade of XBP1 splicing by inhibition of IRE1  is a promising therapeutic option in multiple myeloma

(2012) N. Mimura et al.   BLOOD

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Nelfinavir inhibits regulated intramembrane proteolysis of sterol regulatory element binding protein-1 and activating transcription factor 6 in castration-resistant prostate cancer

(2012) Min Guan et al.   FEBS Journal

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

A quantitative method for detection of spliced X-box binding protein-1 (XBP1) mRNA as a measure of endoplasmic reticulum (ER) stress

(2011) Annemarie van Schadewijk et al.   CELL STRESS & CHAPERONES

Development of Neh2-Luciferase Reporter and Its Application for High Throughput Screening and Real-Time Monitoring of Nrf2 Activators

(2011) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and application of a class of sensors to monitor Ca2+ dynamics in high Ca2+ concentration cellular compartments

(2011) S. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

(2010) I. Papandreou et al.   BLOOD

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Proximity-based Protein Thiol Oxidation by H2O2-scavenging Peroxidases

(2009) Marcus Gutscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

(2009) Q. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of a Family of Redox-Sensitive Green Fluorescent Protein Indicators for Use in Relatively Oxidizing Subcellular Environments†‡

(2008) Jeremy R. Lohman et al.   BIOCHEMISTRY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions

(2008) Philip I. Merksamer et al.   CELL

A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulum

(2008) Markus Rehberg et al.   CELL CALCIUM

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

B- and T-cell Development Both Involve Activity of the Unfolded Protein Response Pathway

(2008) Ryan Brunsing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene

(2008) Peter J. Belmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical calcium indicators

(2008) R. Madelaine Paredes et al.   METHODS

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA