Article
Nutrition & Dietetics
Kok-Lun Pang, Lian-Chee Foong, Norzana Abd Ghafar, Ima Nirwana Soelaiman, Jia Xian Law, Lek Mun Leong, Kok-Yong Chin
Summary: This study investigated the anticancer properties of annatto tocotrienol (AnTT), gamma-tocotrienol (gamma-T3), and delta-tocotrienol (delta-T3) on chondrosarcoma cells. The results showed that these tocotrienols induced G1 arrest and apoptosis in the cells, as well as caused cytoplasmic vacuolation. Transcriptomic analysis revealed upregulated signaling pathways related to endoplasmic reticulum stress, autophagy, and transcription. Several cell proliferation and cancer-related pathways, such as Hippo and Wnt signaling pathways, were also downregulated. Further research is needed to confirm the effectiveness of these tocotrienols as adjuvant therapy for chondrosarcoma.
Article
Pharmacology & Pharmacy
Shuai Wang, Yazhou Guo, Chen Yang, Ruijie Huang, Yuting Wen, Chunyan Zhang, Chenchen Wu, Baoyu Zhao
Summary: Swainsonine induces cell paraptosis through ER stress and MAPK signaling pathway, instead of autophagy or apoptosis, laying a theoretical foundation for the study of its toxicity mechanism.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xue Jiao, Qi Bian, Taotao Feng, Xiaomei Lyu, Hongwei Yu, Lidan Ye
Summary: The d-tocotrienol component of vitamin E has shown impressive activities in radioprotection, neuroprotection, and cholesterol reduction. However, its production is limited by low content in plants and difficulty in separation from other tocotrienols. This study successfully engineered a yeast cell factory to produce and secrete delta-tocotrienol, achieving high production yields and extracellular collection. This research not only provides a promising approach for delta-tocotrienol production, but also offers insights into yeast engineering for secretory production of other terpenoids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Weiwei Ji, Huaqiang Zhu, Bincong Xing, Chu Chu, Tao Ji, Wen Ge, Juan Wang, Xin Peng
Summary: In this study, the mechanism of T. hemsleyanum against febrile seizures was systematically elucidated. It was found that T. hemsleyanum significantly increased seizure latency, decreased seizure duration, and improved abnormal delta and gamma band activity during epileptic discharge. Ten chemical components of T. hemsleyanum were identified, and the therapeutic effect of T. hemsleyanum on febrile seizures might be regulated by inhibiting neuroinflammation through the PKC-d/caspase-1 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Marina Montagnani Marelli, Giangiacomo Beretta, Roberta Manuela Moretti
Summary: Prostate cancer is the fifth leading cause of cancer death in men. Chemotherapeutic agents primarily induce apoptosis in tumor cells, but drug resistance often occurs due to defects in apoptotic cellular responses. As an alternative approach, inducing non-apoptotic cell death, such as necroptosis, may prevent drug resistance. In this study, the involvement of necroptosis in the anticancer activity of delta-tocotrienol in prostate cancer cells (DU145 and PC3) was evaluated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Xue Jiao, Qi Bian, Taotao Feng, Xiaomei Lyu, Hongwei Yu, Lidan Ye
Summary: The component delta-tocotrienol, a form of vitamin E, has demonstrated impressive capabilities in radioprotection, neuroprotection, and cholesterol reduction. However, its production is limited due to its low content in plants and challenges in separating it from other tocotrienols. An alternative approach using a microbial cell factory that exclusively produces and secretes delta-tocotrienol through fermentation has shown promise. By assembling the synthetic pathway for delta-tocotrienol in Saccharomyces cerevisiae and conducting comprehensive pathway engineering, researchers were able to achieve a production yield of 73.45 mg/L. Further optimization with the addition of 2-hydroxypropyl-beta-cyclodextrin (CD) and overexpression of the transcription factor PDR1 increased the delta-tocotrienol titer to 241.7 mg/L, with 30.4% being secreted. Through the proper addition of CD and in situ extractant olive oil, 181.12 mg/L of delta-tocotrienol was collected as an extracellular product, accounting for 85.6% of the total production. This process not only establishes a promising delta-tocotrienol cell factory but also provides insights into yeast engineering for the secretory production of other terpenoids.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Stephen A. Shrum, Ujwani Nukala, Shivangi Shrimali, Edith Nathalie Pineda, Kimberly J. Krager, Shraddha Thakkar, Darin E. Jones, Rupak Pathak, Philip J. Breen, Nukhet Aykin-Burns, Cesar M. Compadre
Summary: Tocotrienols have powerful multi-organ radioprotective effects, involving antioxidant and other signaling effects.
Article
Biology
Min Hee Yang, In Jin Ha, Seok-Geun Lee, Junhee Lee, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: This study investigated the effects of BSN on chronic myelogenous leukemia cells and found that it induces apoptosis, autophagy, and paraptosis. It was also discovered that BSN activates the MAPK signaling pathway.
Article
Cell Biology
Lujia Feng, Yantao Wei, Yimeng Sun, Linbin Zhou, Shaowei Bi, Weirong Chen, Wu Xiang
Summary: Cataracts are a leading cause of blindness worldwide, with age being a major risk factor. The exact mechanisms of cataractogenesis are still unclear. A recent study found that microRNA-34a (MIR34A) is involved in cataract development, but the underlying pathogenesis is unknown. This study showed that hexokinase 1 (HK1) is a target gene of MIR34A and demonstrated that MIR34A modulates lens epithelial cell apoptosis and cataract development through the HK1/caspase 3 signaling pathway.
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Oncology
Yuna Kim, Yoo Jin Bae, Jie-Hyun Kim, Hyunki Kim, Su-Jin Shin, Da Hyun Jung, Hyojin Park
Summary: Trastuzumab-resistant gastric cancer cells exhibit an epithelial-mesenchymal transition (EMT)-like phenotype, and trastuzumab resistance is promoted by the Wnt/beta-catenin signaling pathway. The Wnt/beta-catenin pathway is a key signaling pathway for trastuzumab resistance in gastric cancer cells.
Article
Nutrition & Dietetics
Caibing Wang, Kai Zang, Zexin Tang, Ting Yang, Xiyun Ye, Yongyan Dang
Summary: Hordenine enhances the activity of mouse dermal-papilla cells and promotes hair regrowth through activating the Wnt/β-catenin signaling pathway, suggesting its potential use in preventing and treating alopecia.
Article
Biochemistry & Molecular Biology
Cong Wang, Lijun Liu, Yan Cheng, Huirong Shi
Summary: This study investigated the effects of antineoplastic agents on the stemness and radiotherapy sensitivity of cervical cancer stem cells (CSCs). The results showed that CSCs had stronger abilities in cell spheroidization, proliferation, and tumor formation compared to non-stem cells. The proliferation, anti-apoptosis, and migration of CSCs under ionizing radiation were higher than those of normal cancer cells. Additionally, the combination of GSK-3 beta and MEK inhibitors could activate the Wnt signaling pathway in cervical CSCs, which affected their stemness maintenance and radiotherapy sensitivity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Haopeng Zhang, Jiaren Liu, Guodong Li, Jiufeng Wei, Hongsheng Chen, Chunpeng Zhang, Jinlu Zhao, Yunfeng Wang, Shuwei Dang, Xinglong Li, Xuan Fang, Lianxin Liu, Ming Liu
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2018)
Article
Agriculture, Multidisciplinary
Wen-Guang Sun, Rui-Peng Song, Yong Wang, Ya-Hui Zhang, Hai-Xia Wang, Sheng Ge, Jia-Ren Liu, Lian-Xin Liu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Food Science & Technology
Jia Yu, Hong-Wei Dong, Li-Tian Shi, Xuan-Yue Tang, Jia-Ren Liu, Ji-Hong Shi
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Toxicology
Hong-Wei Dong, Kai Wang, Xiao-Xia Chang, Fei-Fei Jin, Qi Wang, Xiao-Feng Jiang, Jia-Ren Liu, Yong-Hui Wu, Chun Yang
ARCHIVES OF TOXICOLOGY
(2019)
Article
Engineering, Biomedical
Lu Wang, Shubin Li, Yu Kai, Jiang Zhu, Hujie Shi, Baibin Zhou, Jiaren Liu
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Biotechnology & Applied Microbiology
Hongxiao Yang, Lina Shan, Yunan Gao, Lin Li, Guifen Xu, Bin Wang, Xiaoxue Yin, Chengfang Gao, Jiaren Liu, Wei Yang
Summary: The study found that miR-181b is downregulated in HF patients and negatively correlated with hsCRP levels in serum. ROC curve analysis showed that miR-181b is a diagnostic predictor of HF. Overexpression of miR-181b can decrease the expression of inflammatory cytokines in HF rats and cardiomyocytes.
Article
Cardiac & Cardiovascular Systems
Min Zheng, Chengchuang Zhan, Nan Bai, Juncai Bai, Chaoqun Nie, Jing Chi, Xue Ding, Jiaren Liu, Wei Yang
Summary: The study found that 3-BrPA and TMZ individually had no significant effect on the heart, but their combination led to worsened heart function, decreased ATP levels, increased oxidative stress, and myocardial apoptosis. Therefore, concurrent use of 3-BrPA and TMZ is not recommended.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Bin Li, Wen-Xuan Sun, Wan-Ying Zhang, Ye Zheng, Lu Qiao, Yue-Ming Hu, Wei-Qiang Li, Di Liu, Bing Leng, Jia-Ren Liu, Xiao-Feng Jiang, Yan Zhang
Summary: This study classified different subtypes of asthma through molecular expression analysis and identified the molecular basis associated with severe asthma. The research also revealed the association between factors such as neural signals and redox with the severity of asthma.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Hongxiao Yang, Juncai Bai, Chengchuang Zhan, Shuang Liu, Yunan Gao, Lihua Zhong, Yajing Lv, Jing Chi, Jiaren Liu, Xinrui Yang, Wei Yang
Summary: This study demonstrated a protective effect of hydrogen on levothyroxine-induced cardiac hypertrophy in rats by regulating angiotensin II type 1 receptors and NOX2-mediated oxidative stress.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rentong Zou, Chaoqun Nie, Shuang Pan, Bin Wang, Xiaojian Hong, Shuiqing Xi, Juncai Bai, Mengshu Yu, Jiaren Liu, Wei Yang
Summary: Hydrogen inhalation attenuates diabetic cardiomyopathy by reducing pyroptosis and fibrosis, and the combination of hydrogen and metformin exhibits a more potent cardioprotective effect.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Microbiology
Xiao Han, Guiling Zou, Jiaren Liu, Chun Yang, Xuefei Du, Guoyu Chen, Zhe Sun, Xinyu Zhang, Yu Sun, Wanying Zhang, Xiaofeng Jiang
Summary: This study investigated the molecular characteristics and potential resistance mechanisms of linezolid-resistant Staphylococcus capitis isolates from a tertiary hospital in China. A potentially novel mutation, C2128T, that may have an impact on bacterial resistance was identified.
Article
Integrative & Complementary Medicine
Chun-Peng Zhang, Wei-Hua Li, Jia-Ren Liu, Guo-Dong Li, Hao-Peng Zhang, Jiu-Feng Wei, Hong-Sheng Chen, Jin-Lu Zhao, Yun-Feng Wang, Qiang Lv, Ming Liu
Summary: This study demonstrated that blue honeysuckle extract (BHE) inhibits proliferation of hepatocellular carcinoma (HCC) cells by arresting the cell cycle in the G2/M phase. BHE downregulates the expression of conventional dendritic cells-2 (cDC2) and cyclin B1 while upregulating the expression of myelin transcription factor 1 (MyT1). These findings provide a theoretical basis for the potential therapeutic use of blue honeysuckle extract as an inhibitor of HCC.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Plant Sciences
Di Zhang, Nadya Mara Adelina, Ziluan Fan, Jiaren Liu
Summary: This study evaluated the active ingredients, antioxidant, and enzyme-inhibitory activity of different parts of wild lingonberry. Phenolic compounds were found to be significantly higher in the leaf and stem. Fruit exhibited the highest inhibitory activity on acetylcholinesterase and butyrylcholinesterase, while the leaf showed the most potent activity on alpha-amylase, alpha-glucosidase, and tyrosinase. Tyrosinase was strongly correlated with phenolic acids and flavonoids. A total of 29 active ingredients, including phenolic acids, flavonoids, anthocyanins, and triterpenes, were detected. The results suggest that lingonberry has potential as a natural resource for functional food and medicinal development.
JOURNAL OF BERRY RESEARCH
(2022)
Article
Chemistry, Applied
Wenchen Yu, Yi Xiong, Mengnan Liu, Deyong Zeng, Haitian Zhao, Jiaren Liu, Weihong Lu
Summary: ICPC-a is a 45 kDa molecular weight extract from Imperata cylindrica, composed of α-D-1,3-Glcp and α-D-1,6-Glcp. It has thermal stability up to 220°C and exhibits an amorphous nature confirmed by X-ray diffraction analysis, with a layered morphology observed by scanning electron microscopy. ICPC-a significantly reduces uric acid levels, ameliorates uric acid-induced cell injury and apoptosis, and protects against renal injury by modulating multiple pathways including lipid peroxidation, antioxidant damage and defense levels, inflammatory factors secretion, purine metabolism, PI3K-Akt signaling pathway, NF-κB signaling pathway, inflammatory bowel disease, mTOR signaling pathway, and MAPK signaling pathway. These findings highlight ICPC-a as a promising natural substance for further research and development due to its multiple targets, pathways of action, and non-toxicity.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Biomedical
Li Dong, Zhiyuan Shen, Huidi Zhang, Binmei Zhang, Yinze Zhou, Xin Lv, Xiaojian Hong, Jiaren Liu, Wei Yang
Summary: Magnesium alloys are commonly used in medical devices, but little is known about their degradation products. This study identified the unsoluble corrosion products of WE43 alloy and investigated their effects on macrophages, shedding light on their metabolic process and the inflammation-related mechanisms.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
