The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

(2018) Jonathan A. Kropski et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma

(2018) Joanna Kopecka et al.   LUNG CANCER

Apelin-13 Alleviates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Endoplasmic Reticulum Stress-Mediated Apoptosis and Blood-Brain Barrier Disruption: Possible involvement of ATF6/CHOP Pathway

(2018) Weilin Xu et al.   NEUROSCIENCE

Newcastle disease virus induces G 0 /G 1 cell cycle arrest in asynchronously growing cells

(2018) Yan Wang et al.   VIROLOGY

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

(2018) Joy Ogbechi et al.   Cell Death & Disease

Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

(2017) Daisuke Ariyasu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tauroursodeoxycholic Acid Reduces Arterial Stiffness and Improves Endothelial Dysfunction in Type 2 Diabetic Mice

(2017) Micah L. Battson et al.   JOURNAL OF VASCULAR RESEARCH

Porcine circovirus type 2 capsid protein induces unfolded protein response with subsequent activation of apoptosis

(2017) Ying-shan Zhou et al.   Journal of Zhejiang University-SCIENCE B

BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells

(2017) Margaret E. Maes et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The regulation of cellular apoptosis by the ROS-triggered PERK/EIF2α/chop pathway plays a vital role in bisphenol A-induced male reproductive toxicity

(2017) Li Yin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of Apoptosis during Flavivirus Infection

(2017) Toru Okamoto et al.   Viruses-Basel

The Bcl-2 Family in Host-Virus Interactions

(2017) Marc Kvansakul et al.   Viruses-Basel

Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway

(2017) Pan Zhu et al.   Cell Death & Disease

TRB3 reverses chemotherapy resistance and mediates crosstalk between endoplasmic reticulum stress and AKT signaling pathways in MHCC97H human hepatocellular carcinoma cells

(2017) Yang Li et al.   Oncology Letters

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure

(2017) Yufeng Yao et al.   Nature Communications

Shiga Toxins Induce Apoptosis and ER Stress in Human Retinal Pigment Epithelial Cells

(2017) Jun-Young Park et al.   Toxins

Psoralen Inhibited Apoptosis of Osteoporotic Osteoblasts by Modulating IRE1-ASK1-JNK Pathway

(2017) Shuqing Chen et al.   Biomed Research International

Transcription Factor C/EBP Homologous Protein in Health and Diseases

(2017) Yuan Yang et al.   Frontiers in Immunology

Caspase-12 is involved in stretch-induced apoptosis mediated endoplasmic reticulum stress

(2016) Qiang Zhang et al.   APOPTOSIS

Involvement of Endoplasmic Reticulum Stress in Uremic Cardiomyopathy: Protective Effects of Tauroursodeoxycholic Acid

(2016) Wei Ding et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling

(2016) Zixuan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Neddylation Inhibition Activates the Extrinsic Apoptosis Pathway through ATF4–CHOP–DR5 Axis in Human Esophageal Cancer Cells

(2016) Ping Chen et al.   CLINICAL CANCER RESEARCH

Inhibition of endoplasmic reticulum stress-activated IRE1α-TRAF2-caspase-12 apoptotic pathway is involved in the neuroprotective effects of telmisartan in the rotenone rat model of Parkinson's disease

(2016) Qiang Tong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis

(2016) Selma Tuzlak et al.   GENES & DEVELOPMENT

GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis

(2016) Manish K. Gupta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of ER stress in lipid metabolism and lipotoxicity

(2016) Jaeseok Han et al.   JOURNAL OF LIPID RESEARCH

Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy

(2016) Brandon P. Lucke-Wold et al.   JOURNAL OF NEUROSURGERY

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis

(2016) Ehab A Ayaub et al.   JOURNAL OF PATHOLOGY

Functional Implications of the spectrum of BCL2 mutations in Lymphoma

(2016) Khushboo Singh et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer

(2016) J Izrailit et al.   ONCOGENE

The endoplasmic reticulum stress response: A link with tuberculosis?

(2016) Yongyong Cui et al.   TUBERCULOSIS

Porcine Circovirus 2 Deploys PERK Pathway and GRP78 for Its Enhanced Replication in PK-15 Cells

(2016) Yingshan Zhou et al.   Viruses-Basel

HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway

(2016) Ankit Shah et al.   Scientific Reports

CCAAT-Enhancer-Binding Protein Homologous Protein Deficiency Attenuates Oxidative Stress and Renal Ischemia-Reperfusion Injury

(2015) Bo Lin Chen et al.   ANTIOXIDANTS & REDOX SIGNALING

Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells

(2015) Mingjie Huang et al.   ARCHIVES OF VIROLOGY

IRE1α-TRAF2-ASK1 complex-mediated endoplasmic reticulum stress and mitochondrial dysfunction contribute to CXC195-induced apoptosis in human bladder carcinoma T24 cells

(2015) Tao Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C/EBP homologous protein (CHOP) contributes to hepatocyte death via the promotion of ERO1α signalling in acute liver failure

(2015) Jianhua Rao et al.   BIOCHEMICAL JOURNAL

Tanshinone IIA Facilitates TRAIL Sensitization by Up-regulating DR5 through the ROS-JNK-CHOP Signaling Axis in Human Ovarian Carcinoma Cell Lines

(2015) Chia-Che Chang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Involvement of Endoplasmic Reticulum Stress–Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3–Induced Acute Viral MyocarditisCLINICAL PERSPECTIVE

(2015) Zhejun Cai et al.   Circulation-Heart Failure

Targeting unfolded protein response in cancer and diabetes

(2015) S. Mkrtchian   ENDOCRINE-RELATED CANCER

Improvement of chemotherapeutic drug efficacy by endoplasmic reticulum stress

(2015) C. Mihailidou et al.   ENDOCRINE-RELATED CANCER

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

A PDI-catalyzed thiol–disulfide switch regulates the production of hydrogen peroxide by human Ero1

(2015) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells

(2015) Tianliang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction

(2015) Dae-Hwan Nam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of mitochondrial genome expression triggers the activation of CHOP-10 by a cell signaling dependent on the integrated stress response but not the mitochondrial unfolded protein response

(2015) Sebastien Michel et al.   MITOCHONDRION

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics

(2015) A. N. Hata et al.   Cancer Discovery

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells

(2015) Kyong-Jin Jung et al.   Oncotarget

Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4

(2014) Yun-Ji Lim et al.   APOPTOSIS

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

(2014) Gisela Campos et al.   ARCHIVES OF TOXICOLOGY

Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells

(2014) Yosuke Shimodaira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-Regulation of PERK-ATF4-CHOP Pathway by Astragaloside IV is Associated with the Inhibition of Endoplasmic Reticulum Stress-Induced Podocyte Apoptosis in Diabetic Rats

(2014) Yifang Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Dual role for CHOP in the crosstalk between autophagy and apoptosis to determine cell fate in response to amino acid deprivation

(2014) Wafa B'chir et al.   CELLULAR SIGNALLING

Role of Activating Transcription Factor 3 (ATF3) in Endoplasmic Reticulum (ER) Stress-induced Sensitization of p53-deficient Human Colon Cancer Cells to Tumor Necrosis Factor (TNF)-related Apoptosis-inducing Ligand (TRAIL)-mediated Apoptosis through Up-regulation of Death Receptor 5 (DR5) by Zerumbone and Celecoxib

(2014) Makoto Edagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Endoplasmic Reticulum Stress Sensor IRE1  Protects Cells from Apoptosis Induced by the Coronavirus Infectious Bronchitis Virus

(2014) T. S. Fung et al.   JOURNAL OF VIROLOGY

HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction

(2014) Rong Ma et al.   MOLECULAR NEUROBIOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Stressed to death – mechanisms of ER stress-induced cell death

(2013) Natalia Sovolyova et al.   BIOLOGICAL CHEMISTRY

Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis

(2013) Anja Bruchmann et al.   BMC CANCER

HDAC4 protects cells from ER stress induced apoptosis through interaction with ATF4

(2013) Pengfei Zhang et al.   CELLULAR SIGNALLING

The expanding roles of endoplasmic reticulum stress in virus replication and pathogenesis

(2013) Shanshan Li et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α

(2013) CHUN-LEI LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Upregulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway

(2013) Y. Liao et al.   JOURNAL OF VIROLOGY

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Endoplasmic Reticulum Stress Contributes to Helicobacter Pylori VacA-Induced Apoptosis

(2013) Yuko Akazawa et al.   PLoS One

Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells

(2013) E Sanchez-Lopez et al.   Cell Death & Disease

Structural Basis of the Unfolded Protein Response

(2012) Alexei Korennykh et al.   Annual Review of Cell and Developmental Biology

Attenuating Endoplasmic Reticulum Stress as a Novel Therapeutic Strategy in Pulmonary Hypertension

(2012) Peter Dromparis et al.   CIRCULATION

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

(2012) Jie Cao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Up-Regulation of Mcl-1 and Bak by Coronavirus Infection of Human, Avian and Animal Cells Modulates Apoptosis and Viral Replication

(2012) Yanxin Zhong et al.   PLoS One

CHOP Potentially Co-Operates with FOXO3a in Neuronal Cells to Regulate PUMA and BIM Expression in Response to ER Stress

(2012) Arindam P. Ghosh et al.   PLoS One

Stress-Inducible Caspase Substrate TRB3 Promotes Nuclear Translocation of Procaspase-3

(2012) Kouhei Shimizu et al.   PLoS One

Autophagy: A novel guardian of HCV against innate immune response

(2011) Po-Yuan Ke et al.   Autophagy

The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway

(2011) Zhen Liu et al.   CELLULAR MICROBIOLOGY

Attenuation of CHOP-mediated Myocardial Apoptosis in Pressure-overloaded Dominant Negative p38α Mitogen-activated Protein Kinase Mice

(2011) Flori R. Sari et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

(2011) Yun-Ji Lim et al.   PLoS One

UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression

(2010) Carla R. Bromati et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Endoplasmic Reticulum Stress-C/EBP Homologous Protein Pathway-Mediated Apoptosis in Macrophages Contributes to the Instability of Atherosclerotic Plaques

(2010) Hiroto Tsukano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative protein folding in the endoplasmic reticulum: Tight links to the mitochondria-associated membrane (MAM)

(2010) Thomas Simmen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

TRB3 Function in Cardiac Endoplasmic Reticulum Stress

(2010) Joan Avery et al.   CIRCULATION RESEARCH

Endoplasmic reticulum stress response is involved inMycobacterium tuberculosisprotein ESAT-6-mediated apoptosis

(2010) Hong-Hee Choi et al.   FEBS LETTERS

Signaling through C/EBP Homologous Protein and Death Receptor 5 and Calpain Activation Differentially Regulate THP-1 Cell Maturation-Dependent Apoptosis Induced by Shiga Toxin Type 1

(2010) M.-S. Lee et al.   INFECTION AND IMMUNITY

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

(2010) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4-CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

(2010) Z. Galehdar et al.   JOURNAL OF NEUROSCIENCE

Coxsackievirus B3 Infection Activates the Unfolded Protein Response and Induces Apoptosis through Downregulation of p58IPK and Activation of CHOP and SREBP1

(2010) H. M. Zhang et al.   JOURNAL OF VIROLOGY

West Nile Virus Differentially Modulates the Unfolded Protein Response To Facilitate Replication and Immune Evasion

(2010) R. L. Ambrose et al.   JOURNAL OF VIROLOGY

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

(2010) Tracie A. Seimon et al.   PLoS One

Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis

(2009) John D. Cravero et al.   ARTHRITIS AND RHEUMATISM

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways

(2009) Can E. Senkal et al.   FASEB JOURNAL

TRB3, upregulated by ox-LDL, mediates human monocyte-derived macrophage apoptosis

(2009) Yuan-yuan Shang et al.   FEBS Journal

Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells

(2009) M.-S. Lee et al.   INFECTION AND IMMUNITY

Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis

(2009) Gang Li et al.   JOURNAL OF CELL BIOLOGY

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways

(2009) Jenelle M. Timmins et al.   JOURNAL OF CLINICAL INVESTIGATION

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Staying alive: bacterial inhibition of apoptosis during infection

(2008) Christina S. Faherty et al.   TRENDS IN MICROBIOLOGY