Activation mechanisms and structural dynamics of STIM proteins

Functional communication between IP3R and STIM2 at subthreshold stimuli is a critical checkpoint for initiation of SOCE

(2022) Moaz Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Lipids in CRAC Channel Function

(2022) Lena Maltan et al.   Biomolecules

The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping

(2022) Ji-Hee Kim et al.   CELL CALCIUM

STIM1 and ORAI1 mutations leading to tubular aggregate myopathies are sensitive to the Store-operated Ca2+-entry modulators CIC-37 and CIC-39

(2022) Beatrice Riva et al.   CELL CALCIUM

Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca2+ sensor STIM1

(2022) Nisha Shrestha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic S-acylation of the ER-resident protein stromal interaction molecule 1 (STIM1) is required for store-operated Ca2+ entry

(2022) Goutham Kodkandla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Case Report: Novel STIM1 Gain-of-Function Mutation in a Patient With TAM/STRMK and Immunological Involvement

(2022) Eduardo de la Fuente-Munoz et al.   Frontiers in Immunology

An S-glutathiomimetic provides structural insights into stromal interaction molecule-1 regulation

(2022) Christian Sirko et al.   JOURNAL OF MOLECULAR BIOLOGY

CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development

(2022) Adéla Tiffner et al.   Cancers

More Than Just Simple Interaction between STIM and Orai Proteins: CRAC Channel Function Enabled by a Network of Interactions with Regulatory Proteins

(2021) Sascha Berlansky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

STIM Proteins: An Ever-Expanding Family

(2021) Herwig Grabmayr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

p.E152K-STIM1 mutation deregulates Ca2+ signaling contributing to chronic pancreatitis

(2021) Miguel Burgos et al.   JOURNAL OF CELL SCIENCE

Gain-of-Function STIM1 L96V Mutation Causes Myogenesis Alteration in Muscle Cells From a Patient Affected by Tubular Aggregate Myopathy

(2021) Elena Conte et al.   Frontiers in Cell and Developmental Biology

A short isoform of STIM1 confers frequency-dependent synaptic enhancement

(2021) Girish Ramesh et al.   Cell Reports

Regulation of Dynamic Protein S-Acylation

(2021) Jessica J. Chen et al.   Frontiers in Molecular Biosciences

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade

(2021) Carmen Höglinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expanding the clinical and genetic spectrum of pathogenic variants in STIM1

(2021) Chiara Ticci et al.   MUSCLE & NERVE

Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure

(2021) Roberto Silva-Rojas et al.   Cells

A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP‐modulated NFAT signaling

(2021) Mona L Knapp et al.   EMBO REPORTS

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

(2021) Stijn van Dorp et al.   eLife

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

(2021) Amado Carreras-Sureda et al.   eLife

Genetic defects are common in myopathies with tubular aggregates

(2021) Qiang Gang et al.   Annals of Clinical and Translational Neurology

Optogenetic engineering to probe the molecular choreography of STIM1-mediated cell signaling

(2020) Guolin Ma et al.   Nature Communications

STIM1 controls calcineurin/Akt/mTOR/NFATC2‑mediated osteoclastogenesis induced by RANKL/M‑CSF

(2020) Yanjiao Huang et al.   Experimental and Therapeutic Medicine

Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

(2020) Matthias Sallinger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical and muscle MRI features in a family with tubular aggregate myopathy and novel STIM1 mutation

(2020) Thomas Claeys et al.   NEUROMUSCULAR DISORDERS

CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity

(2020) Martin Vaeth et al.   TRENDS IN IMMUNOLOGY

Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets

(2020) Daniel Bakowski et al.   Annual Review of Pharmacology and Toxicology

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation

(2020) Petr Rathner et al.   Nature Chemical Biology

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1

(2020) Jin Seok Woo et al.   Scientific Reports

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

(2020) Xiaowei Hou et al.   eLife

Mechanistic insights into the Orai channel by molecular dynamics simulations

(2019) Daniel Bonhenry et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

(2019) Carmen Butorac et al.   CELL CALCIUM

Molecular understanding of calcium permeation through the open Orai channel

(2019) Xiaofen Liu et al.   PLOS BIOLOGY

Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels

(2019) Pradeep Barak et al.   Cold Spring Harbor Perspectives in Biology

Store-Operated Calcium Channels: From Function to Structure and Back Again

(2019) Richard S. Lewis   Cold Spring Harbor Perspectives in Biology

Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain

(2019) Masahiro Enomoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Changes in STIM Isoforms Expression and Gender-Specific Alterations in Orai Expression in Human Heart Failure

(2019) R. ČENDULA et al.   PHYSIOLOGICAL RESEARCH

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding

(2019) Romana Schober et al.   Science Signaling

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

(2019) Tomoki Naito et al.   eLife

STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone

(2019) Thilini H. Gamage et al.   CELL CALCIUM

Inositol 1,4,5-trisphosphate receptors and neurodegenerative disorders

(2018) Polina A. Egorova et al.   FEBS Journal

A charge-sensing region in the stromal interaction molecule 1 luminal domain confers stabilization-mediated inhibition of SOCE in response toS-nitrosylation

(2018) Jinhui Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels

(2018) Jill L. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EB1 binding restricts STIM1 translocation to ER–PM junctions and regulates store-operated Ca2+entry

(2018) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

EB1 traps STIM1 and regulates local store-operated Ca2+entry

(2018) Qiao-Chu Wang et al.   JOURNAL OF CELL BIOLOGY

Ca 2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy

(2018) Sabourin Jessica et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

S -Nitrosylation of STIM1 by Neuronal Nitric Oxide Synthase Inhibits Store-Operated Ca 2+ Entry

(2018) Le Gui et al.   JOURNAL OF MOLECULAR BIOLOGY

Ca2+ and lipid signals hold hands at endoplasmic reticulum-plasma membrane contact sites

(2018) Tamas Balla   JOURNAL OF PHYSIOLOGY-LONDON

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

(2018) Marc Fahrner et al.   Nature Communications

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

(2018) Krishna Prasad Subedi et al.   Cell Reports

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

(2018) Marina Besprozvannaya et al.   eLife

Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome

(2018) Johann Böhm et al.   CELL CALCIUM

STIM1 deficiency is linked to Alzheimer’s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry

(2018) Carlos Pascual-Caro et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Structures reveal opening of the store-operated calcium channel Orai

(2018) Xiaowei Hou et al.   eLife

STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription

(2018) Romana Schober et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

STIM1 activation of Orai1

(2018) Victoria Lunz et al.   CELL CALCIUM

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice

(2018) Thilini H. Gamage et al.   CELL CALCIUM

The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains

(2018) Steve Chung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Calcium sensing by the STIM1 ER-luminal domain

(2018) Aparna Gudlur et al.   Nature Communications

Identification of molecular determinants that govern distinct STIM2 activation dynamics

(2018) Sisi Zheng et al.   PLOS BIOLOGY

Stormorken Syndrome Caused by a p.R304W STIM1 Mutation: The First Italian Patient and a Review of the Literature

(2018) Oscar Borsani et al.   Frontiers in Neurology

Identification and characterization of three novel mutations in the CASQ1 gene in four patients with tubular aggregate myopathy

(2017) Virginia Barone et al.   HUMAN MUTATION

Communication between N terminus and loop2 tunes Orai activation

(2017) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RASSF4: Regulator of plasma membrane PI(4,5)P2

(2017) Eamonn J. Dickson   JOURNAL OF CELL BIOLOGY

RASSF4 controls SOCE and ER–PM junctions through regulation of PI(4,5)P2

(2017) Yu-Ju Chen et al.   JOURNAL OF CELL BIOLOGY

Tubular aggregate myopathy with features of Stormorken disease due to a new STIM1 mutation

(2017) Jean-Baptiste Noury et al.   NEUROMUSCULAR DISORDERS

Complex phenotypes associated with STIM1 mutations in both coiled coil and EF-hand domains

(2017) Elizabeth Harris et al.   NEUROMUSCULAR DISORDERS

Expression of STIM1 is associated with tumor aggressiveness and poor prognosis in breast cancer

(2017) Yanfang Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

(2017) Thomas D. Goddard et al.   PROTEIN SCIENCE

Optical control of membrane tethering and interorganellar communication at nanoscales

(2017) Lian He et al.   Chemical Science

STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca2+ Entry

(2017) Pascal Yazbeck et al.   Scientific Reports

Stim2-Eb3 Association and Morphology of Dendritic Spines in Hippocampal Neurons

(2017) Ekaterina Pchitskaya et al.   Scientific Reports

Changing calcium: CRAC channel (STIM and Orai) expression, splicing, and posttranslational modifiers

(2016) Barbara A. Niemeyer   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction

(2016) Aran Son et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Homeostatic regulation of the PI(4,5)P 2 –Ca 2+ signaling system at ER–PM junctions

(2016) Chi-Lun Chang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel

(2016) Michelle Yen et al.   BIOPHYSICAL JOURNAL

Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer

(2016) Jianling Xia et al.   CANCER LETTERS

The Orai1 Store-operated Calcium Channel Functions as a Hexamer

(2016) Xiangyu Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stromal interaction molecule 1 plays an important role in gastric cancer progression

(2016) JIN-MEI XU et al.   ONCOLOGY REPORTS

Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca2+dynamics in T cells

(2016) Jin Seok Woo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol modulates Orai1 channel function

(2016) Isabella Derler et al.   Science Signaling

A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions

(2016) Jonathan Pacheco et al.   Scientific Reports

Cholesterol modulates Orai1 channel function

(2016) Isabella Derler et al.   Science Signaling

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

Phosphoinositides regulate ion channels

(2015) Bertil Hille et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The ER/PM microdomain, PI(4,5)P2 and the regulation of STIM1–Orai1 channel function

(2015) Xu Cao et al.   CELL CALCIUM

The STIM1–ORAI1 microdomain

(2015) Patrick G Hogan   CELL CALCIUM

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ltc1 is an ER-localized sterol transporter and a component of ER–mitochondria and ER–vacuole contacts

(2015) Andrew Murley et al.   JOURNAL OF CELL BIOLOGY

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1

(2015) Thomas Markello et al.   MOLECULAR GENETICS AND METABOLISM

Optogenetic control of endogenous Ca2+ channels in vivo

(2015) Taeyoon Kyung et al.   NATURE BIOTECHNOLOGY

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

50 years to diagnosis: Autosomal dominant tubular aggregate myopathy caused by a novel STIM1 mutation

(2015) Maggie C. Walter et al.   NEUROMUSCULAR DISORDERS

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

(2015) Mate Maus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

Light generation of intracellular Ca2+ signals by a genetically encoded protein BACCS

(2015) Tomohiro Ishii et al.   Nature Communications

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport

(2015) Alberto T Gatta et al.   eLife

Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

(2015) Lian He et al.   eLife

Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome

(2014) Gilles Morin et al.   HUMAN MUTATION

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels

(2014) Naveen Bojjireddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative Signaling via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin

(2014) Auditi DebRoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and SLC24A4 Are Critical for Enamel Maturation

(2014) S. Wang et al.   JOURNAL OF DENTAL RESEARCH

Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1

(2014) Johann Böhm et al.   JOURNAL OF MEDICAL GENETICS

Intrinsic Disorder Mediates Cooperative Signal Transduction in STIM1

(2014) Yukio Furukawa et al.   JOURNAL OF MOLECULAR BIOLOGY

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression

(2014) J-Y Wang et al.   ONCOGENE

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

(2014) Jozsef Maléth et al.   Nature Communications

Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy

(2013) Johann Böhm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

An aromatic amino acid in the coiled-coil 1 domain plays a crucial role in the auto-inhibitory mechanism of STIM1

(2013) Junwei Yu et al.   BIOCHEMICAL JOURNAL

Oligomerization and Ca2+/calmodulin control binding of the ER Ca2+-sensors STIM1 and STIM2 to plasma membrane lipids

(2013) Rajesh Bhardwaj et al.   BIOSCIENCE REPORTS

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium

(2013) Isaac Jardin et al.   CELLULAR SIGNALLING

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

(2013) Archana Jha et al.   JOURNAL OF CELL BIOLOGY

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

(2013) Y.-T. Chen et al.   JOURNAL OF CELL SCIENCE

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Inhibitory Helix Controls the Intramolecular Conformational Switching of the C-Terminus of STIM1

(2013) Boyang Cui et al.   PLoS One

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions

(2013) Chi-Lun Chang et al.   Cell Reports

Different binding property of STIM1 and its novel splice variant STIM1L to Orai1, TRPC3, and TRPC6 channels

(2012) Takahiro Horinouchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycines: Role in α-Helical Membrane Protein Structures and a Potential Indicator of Native Conformation

(2012) Hao Dong et al.   BIOCHEMISTRY

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle

(2012) Salvatore Mancarella et al.   FASEB JOURNAL

Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+Channel Orai1

(2012) Tatiana Kilch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Orai1 and STIM1 Proteins Alters Regulation of Store-operated Ca2+Entry by Endogenous Mediators

(2012) Tomasz Gwozdz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome

(2012) K. T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)

(2012) S. Srikanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

(2011) Salvatore Mancarella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Channel Regulation by Protein Palmitoylation

(2011) Michael J. Shipston   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and STIM2 Are Located in the Acidic Ca2+Stores and Associates with Orai1 upon Depletion of the Acidic Stores in Human Platelets

(2011) Hanene Zbidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools

(2011) N. Calloway et al.   JOURNAL OF CELL SCIENCE

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

STIM1-dependent store-operated Ca2+ entry is required for pathological cardiac hypertrophy

(2011) Xiang Luo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sensing cellular stress through STIM proteins

(2011) Jonathan Soboloff et al.   Nature Chemical Biology

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems

(2011) Sean R. Collins et al.   TRENDS IN CELL BIOLOGY

Evidence for an interaction between Golli and STIM1 in store-operated calcium entry

(2010) Ciara M. Walsh et al.   BIOCHEMICAL JOURNAL

A Basic Sequence in STIM1 Promotes Ca2+Influx by Interacting with the C-Terminal Acidic Coiled Coil of Orai1

(2010) Nathaniel Calloway et al.   BIOCHEMISTRY

Lipid rafts modulate the activation but not the maintenance of store-operated Ca2+ entry

(2010) Carmen Galan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protein Kinase C-induced Phosphorylation of Orai1 Regulates the Intracellular Ca2+Level via the Store-operated Ca2+Channel

(2010) Takumi Kawasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM proteins: integrators of signalling pathways in development, differentiation and disease

(2010) Lorna S. Johnstone et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma

(2010) Minji Byun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

IP3 receptor subtype-dependent activation of store-operated calcium entry through ICRAC

(2009) Christine Peinelt et al.   CELL CALCIUM

Visualizing the store-operated channel complex assembly in real time: Identification of SERCA2 as a new member

(2009) Alicia Sampieri et al.   CELL CALCIUM

Mechanistic view on domains mediating STIM1-Orai coupling

(2009) Marc Fahrner et al.   IMMUNOLOGICAL REVIEWS

Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides

(2009) Marek K. Korzeniowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

(2009) Yandong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STIM1Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

(2009) Capucine Picard et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Conserved, Lipid-Mediated Sorting Mechanism of Yeast Ist2 and Mammalian STIM Proteins to the Peripheral ER

(2009) Ebru Ercan et al.   TRAFFIC

Biophysical characterization of the EF-hand and SAM domain containing Ca2+ sensory region of STIM1 and STIM2

(2008) Le Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

STIM1 Is a MT-Plus-End-Tracking Protein Involved in Remodeling of the ER

(2008) Ilya Grigoriev et al.   CURRENT BIOLOGY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

ATP depletion induces translocation of STIM1 to puncta and formation of STIM1–ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP

(2008) Michael Chvanov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY