Mapping interactions between the CRAC activation domain and CC1 regulating the activity of the ER Ca2+ sensor STIM1

Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade

(2021) Carmen Höglinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physiological Functions of CRAC Channels

(2021) Scott M. Emrich et al.   Annual Review of Physiology

Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

(2021) Stijn van Dorp et al.   eLife

CRAC Channels and Calcium Signaling in T Cell-Mediated Immunity

(2020) Martin Vaeth et al.   TRENDS IN IMMUNOLOGY

Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation

(2020) Petr Rathner et al.   Nature Chemical Biology

Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory

(2020) Mohammad Mehdi Maneshi et al.   Cell Reports

A novel STIM1-Orai1 gating interface essential for CRAC channel activation

(2019) Carmen Butorac et al.   CELL CALCIUM

Molecular basis of allosteric Orai1 channel activation by STIM1

(2019) Priscilla See‐Wai Yeung et al.   JOURNAL OF PHYSIOLOGY-LONDON

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

(2019) Anna B. Toth et al.   Science Signaling

STIM calcium sensing and conformational change

(2019) Aparna Gudlur et al.   JOURNAL OF PHYSIOLOGY-LONDON

Store-Operated Calcium Channels: From Function to Structure and Back Again

(2019) Richard S. Lewis   Cold Spring Harbor Perspectives in Biology

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

(2018) Marc Fahrner et al.   Nature Communications

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

STIM1 activation of Orai1

(2018) Victoria Lunz et al.   CELL CALCIUM

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

(2017) Xin Li et al.   Nature Communications

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural and Functional Mechanisms of CRAC Channel Regulation

(2015) Ann Hye-Ryong Shim et al.   JOURNAL OF MOLECULAR BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Inside-out Ca2+ signalling prompted by STIM1 conformational switch

(2015) Guolin Ma et al.   Nature Communications

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 and SLC24A4 Are Critical for Enamel Maturation

(2014) S. Wang et al.   JOURNAL OF DENTAL RESEARCH

Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis

(2014) V. Nesin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Conformational dynamics of STIM1 activation

(2013) Stefan Feske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

CRAC channelopathies

(2010) Stefan Feske   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+entry in the immune system and beyond

(2009) Stefan Feske   IMMUNOLOGICAL REVIEWS

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE