Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions

(2011) Silvia Carrasco et al.   Annual Review of Biochemistry

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states

(2011) A. Demuro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

(2011) S. L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

(2010) Patrick G. Hogan et al.   Annual Review of Immunology

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

(2010) Annette Lis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pore architecture of the ORAI1 store-operated calcium channel

(2010) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle

(2010) Liang Feng et al.   SCIENCE

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Reconstitution of Purified Human Hv1 H+ Channels

(2009) Seok-Yong Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural determinants of ion permeation in CRAC channels

(2009) Beth A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy

(2008) Laura Navarro-Borelly et al.   JOURNAL OF PHYSIOLOGY-LONDON

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Functional stoichiometry of the unitary calcium-release-activated calcium channel

(2008) W. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON