Luminal STIM1 Mutants that Cause Tubular Aggregate Myopathy Promote Autophagic Processes

Mechanistic insights into the Orai channel by molecular dynamics simulations

(2019) Daniel Bonhenry et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Live-Cell Imaging of Physiologically Relevant Metal Ions Using Genetically Encoded FRET-Based Probes

(2019) Helmut Bischof et al.   Cells

Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation

(2019) Gilles Morin et al.   HUMAN MUTATION

Coordination of a Single Calcium Ion in the EF-hand Maintains the Off State of the Stromal Interaction Molecule Luminal Domain

(2019) Masahiro Enomoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Sequential activation of STIM1 links Ca2+ with luminal domain unfolding

(2019) Romana Schober et al.   Science Signaling

TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKKβ/VPS34 pathway

(2019) A. Scotto Rosato et al.   Nature Communications

SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation

(2018) Zhen-Dong Zhu et al.   Cell Death & Disease

STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription

(2018) Romana Schober et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium sensing by the STIM1 ER-luminal domain

(2018) Aparna Gudlur et al.   Nature Communications

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription

(2017) Irene Frischauf et al.   Science Signaling

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Calmodulin and STIM proteins: Two major calcium sensors in the cytoplasm and endoplasmic reticulum

(2015) Christopher B. Marshall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

(2015) Catherine L. Nezich et al.   JOURNAL OF CELL BIOLOGY

Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

(2015) Pulak Kar et al.   MOLECULAR CELL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

(2015) I. Frischauf et al.   Science Signaling

A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription

(2015) I. Frischauf et al.   Science Signaling

Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1

(2014) Pulak Kar et al.   CURRENT BIOLOGY

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

(2014) Marc Fahrner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1

(2014) Johann Böhm et al.   JOURNAL OF MEDICAL GENETICS

Intrinsic Disorder Mediates Cooperative Signal Transduction in STIM1

(2014) Yukio Furukawa et al.   JOURNAL OF MOLECULAR BIOLOGY

Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy

(2013) Johann Böhm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

CRAC Channels Drive Digital Activation and Provide Analog Control and Synergy to Ca2+-Dependent Gene Regulation

(2012) Pulak Kar et al.   CURRENT BIOLOGY

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal

(2009) Srinivas Honnappa et al.   CELL

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 gates the store-operated calcium channel ORAI1 in vitro

(2009) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

(2009) L. Orci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

(2008) Riina M. Luik et al.   NATURE

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

(2007) Suhel Parvez et al.   FASEB JOURNAL