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Title
Communication between N terminus and loop2 tunes Orai activation
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 293, Issue 4, Pages 1271-1285
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2017-12-14
DOI
10.1074/jbc.m117.812693
References
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Related references
Note: Only part of the references are listed.- Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus
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- STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
- (2017) Megumi Yamashita et al. Nature Communications
- Cholesterol modulates Orai1 channel function
- (2016) Isabella Derler et al. Science Signaling
- The STIM1-binding site nexus remotely controls Orai1 channel gating
- (2016) Yandong Zhou et al. Nature Communications
- Cholesterol modulates Orai1 channel function
- (2016) Isabella Derler et al. Science Signaling
- Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating
- (2015) Raz Palty et al. CELL RESEARCH
- A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription
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- A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription
- (2015) I. Frischauf et al. Science Signaling
- Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels
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- A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)
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- Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis
- (2014) V. Nesin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
- (2013) Isabella Derler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differential Roles of the C and N Termini of Orai1 Protein in Interacting with Stromal Interaction Molecule 1 (STIM1) for Ca2+Release-activated Ca2+(CRAC) Channel Activation
- (2013) Hongying Zheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels
- (2013) Beth A. McNally et al. JOURNAL OF PHYSIOLOGY-LONDON
- Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure
- (2013) B. S. Rothberg et al. Science Signaling
- Gated regulation of CRAC channel ion selectivity by STIM1
- (2012) Beth A. McNally et al. NATURE
- Crystal Structure of the Calcium Release-Activated Calcium Channel Orai
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- Linking of Sensor Molecules with Amino Groups to Amino-Functionalized AFM Tips
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- Cooperativeness of Orai Cytosolic Domains Tunes Subtype-specific Gating
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- Molecular Determinants within N Terminus of Orai3 Protein That Control Channel Activation and Gating
- (2011) Judith Bergsmann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Third Transmembrane Segment of Orai1 Protein Modulates Ca2+Release-activated Ca2+(CRAC) Channel Gating and Permeation Properties
- (2011) Sonal Srikanth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91
- (2011) S. L. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The STIM/Orai coupling machinery
- (2010) Irene Frischauf et al. Channels
- Competitive Modulation of Ca2+Release-activated Ca2+Channel Gating by STIM1 and 2-Aminoethyldiphenyl Borate
- (2010) Megumi Yamashita et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating
- (2010) Annette Lis et al. JOURNAL OF GENERAL PHYSIOLOGY
- Pore architecture of the ORAI1 store-operated calcium channel
- (2010) Y. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling
- (2010) I. Bogeski et al. Science Signaling
- STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1
- (2009) Chan Young Park et al. CELL
- The Intracellular Loop of Orai1 Plays a Central Role in Fast Inactivation of Ca2+Release-activated Ca2+Channels
- (2009) Sonal Srikanth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels
- (2009) Isabella Derler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased Hydrophobicity at the N Terminus/Membrane Interface Impairs Gating of the Severe Combined Immunodeficiency-related ORAI1 Mutant
- (2009) Isabella Derler et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels
- (2009) K. P. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels
- (2009) F. M. Mullins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural determinants of ion permeation in CRAC channels
- (2009) Beth A. McNally et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Store-dependent and -independent Modes Regulating Ca2+Release-activated Ca2+Channel Activity of Human Orai1 and Orai3
- (2008) Shenyuan L. Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- 2-Aminoethoxydiphenyl Borate Alters Selectivity of Orai3 Channels by Increasing Their Pore Size
- (2008) Rainer Schindl et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation
- (2008) Martin Muik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Complex Actions of 2-Aminoethyldiphenyl Borate on Store-operated Calcium Entry
- (2008) Wayne I. DeHaven et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy
- (2008) Laura Navarro-Borelly et al. JOURNAL OF PHYSIOLOGY-LONDON
- 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels
- (2008) Christine Peinelt et al. JOURNAL OF PHYSIOLOGY-LONDON
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