The TAM-associated STIM1I484R mutation increases ORAI1 channel function due to a reduced STIM1 inactivation break and an absence of microtubule trapping

Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated calcium entry

(2022) Christopher Henry et al.   JOURNAL OF CELL SCIENCE

Ryanodine receptor activity and store‐operated Ca 2+ entry: Critical regulators of Ca 2+ content and function in skeletal muscle

(2022) Luke Pearce et al.   JOURNAL OF PHYSIOLOGY-LONDON

A short isoform of STIM1 confers frequency-dependent synaptic enhancement

(2021) Girish Ramesh et al.   Cell Reports

Tubular aggregate myopathy and Stormorken syndrome: Mutation spectrum and genotype/phenotype correlation

(2019) Gilles Morin et al.   HUMAN MUTATION

Fine-tuning of store-operated calcium entry by fast and slow Ca 2+ -dependent inactivation: Involvement of SARAF

(2018) Isaac Jardín et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

EB1 binding restricts STIM1 translocation to ER–PM junctions and regulates store-operated Ca2+entry

(2018) Chi-Lun Chang et al.   JOURNAL OF CELL BIOLOGY

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines

(2018) Sisi Zheng et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm

(2018) Nupura Hirve et al.   Cell Reports

Gain-of-function mutations in STIM1 and ORAI1 causing tubular aggregate myopathy and Stormorken syndrome

(2018) Johann Böhm et al.   CELL CALCIUM

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

(2017) Xin Li et al.   Nature Communications

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

Orai1 pore residues control CRAC channel inactivation independently of calmodulin

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

York platelet syndrome is a CRAC channelopathy due to gain-of-function mutations in STIM1

(2015) Thomas Markello et al.   MOLECULAR GENETICS AND METABOLISM

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Dominant mutations in ORAI1 cause tubular aggregate myopathy with hypocalcemia via constitutive activation of store-operated Ca2+ channels

(2014) Yukari Endo et al.   HUMAN MOLECULAR GENETICS

Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome

(2014) Gilles Morin et al.   HUMAN MUTATION

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

Clinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1

(2014) Johann Böhm et al.   JOURNAL OF MEDICAL GENETICS

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

(2014) Jozsef Maléth et al.   Nature Communications

Constitutive Activation of the Calcium Sensor STIM1 Causes Tubular-Aggregate Myopathy

(2013) Johann Böhm et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

(2013) Archana Jha et al.   JOURNAL OF CELL BIOLOGY

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle

(2010) Joshua N. Edwards et al.   CELL CALCIUM

A new syndrome: thrombocytopathia, muscle fatigue, asplenia, miosis, migraine, dyslexia and ichthyosis

(2010) Helge Stormorken et al.   CLINICAL GENETICS

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Mechanistic view on domains mediating STIM1-Orai coupling

(2009) Marc Fahrner et al.   IMMUNOLOGICAL REVIEWS

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Ca2+flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle

(2009) Bradley S. Launikonis et al.   JOURNAL OF PHYSIOLOGY-LONDON

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

(2008) Jonathan Stiber et al.   NATURE CELL BIOLOGY