Orai1 and STIM1 in ER/PM junctions: roles in pancreatic cell function and dysfunction

The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing

(2016) Jane E. Sexton et al.   NEUROSCIENCE LETTERS

Store-operated Ca2+-entry and adenylyl cyclase

(2015) Dermot M.F. Cooper   CELL CALCIUM

Ca2+ microdomains organized by junctophilins

(2015) Hiroshi Takeshima et al.   CELL CALCIUM

Generation and functions of second messengers microdomains

(2015) Riccardo Filadi et al.   CELL CALCIUM

Molecular determinants of TRPC1 regulation within ER–PM junctions

(2015) Hwei Ling Ong et al.   CELL CALCIUM

Coupling acidic organelles with the ER through Ca2+ microdomains at membrane contact sites

(2015) Christopher J. Penny et al.   CELL CALCIUM

The ER/PM microdomain, PI(4,5)P2 and the regulation of STIM1–Orai1 channel function

(2015) Xu Cao et al.   CELL CALCIUM

The STIM1–ORAI1 microdomain

(2015) Patrick G Hogan   CELL CALCIUM

Molecular mechanisms of inter-organelle ER–PM contact sites

(2015) W Mike Henne et al.   CURRENT OPINION IN CELL BIOLOGY

Membrane contact sites, gateways for lipid homeostasis

(2015) Sujoy Lahiri et al.   CURRENT OPINION IN CELL BIOLOGY

The mitochondria–plasma membrane contact site

(2015) Benedikt Westermann   CURRENT OPINION IN CELL BIOLOGY

Phosphatidylinositol-Phosphatidic Acid Exchange by Nir2 at ER-PM Contact Sites Maintains Phosphoinositide Signaling Competence

(2015) Yeun Ju Kim et al.   DEVELOPMENTAL CELL

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells

(2015) Vina Z. Zinn et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

(2015) Li Wen et al.   GASTROENTEROLOGY

Extended Synaptotagmin Interaction with the Fibroblast Growth Factor Receptor Depends on Receptor Conformation, Not Catalytic Activity

(2015) Michel G. Tremblay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 4,5-Bisphosphate Homeostasis Regulated by Nir2 and Nir3 Proteins at Endoplasmic Reticulum-Plasma Membrane Junctions

(2015) Chi-Lun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

A fluid secretion pathway unmasked by acinar-specificTmem16Agene ablation in the adult mouse salivary gland

(2015) Marcelo A. Catalán et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

K-Cl cotransporters, cell volume homeostasis, and neurological disease

(2015) Kristopher T. Kahle et al.   TRENDS IN MOLECULAR MEDICINE

TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases

(2014) Debbie Willoughby et al.   BIOCHEMICAL JOURNAL

Polarization of the Endoplasmic Reticulum by ER-Septin Tethering

(2014) Jesse T. Chao et al.   CELL

cAMP and Ca2+ signaling in secretory epithelia: Crosstalk and synergism

(2014) Malini Ahuja et al.   CELL CALCIUM

Calcium signaling in pancreatic ductal epithelial cells: An old friend and a nasty enemy

(2014) József Maléth et al.   CELL CALCIUM

Ca2+-regulated secretory granule exocytosis in pancreatic and parotid acinar cells

(2014) Scott W. Messenger et al.   CELL CALCIUM

Molecular Determinants Mediating Gating of Transient Receptor Potential Canonical (TRPC) Channels by Stromal Interaction Molecule 1 (STIM1)

(2014) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Homer2 Protein Regulates Plasma Membrane Ca2+-ATPase-mediated Ca2+Signaling in Mouse Parotid Gland Acinar Cells

(2014) Yu-Mi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

(2014) William A. Prinz   JOURNAL OF CELL BIOLOGY

X-ray structure of a calcium-activated TMEM16 lipid scramblase

(2014) Janine D. Brunner et al.   NATURE

Intrinsically Disordered Linker and Plasma Membrane-Binding Motif Sort Ist2 and Ssy1 to Junctions

(2014) Annemarie Kralt et al.   TRAFFIC

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

(2014) Jozsef Maléth et al.   Nature Communications

Spatial control of the βAR system in heart failure: the transverse tubule and beyond

(2013) Julia Gorelik et al.   CARDIOVASCULAR RESEARCH

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

(2013) Francesca Giordano et al.   CELL

Emerging roles of store-operated Ca2+entry through STIM and ORAI proteins in immunity, hemostasis and cancer

(2013) Wolfgang Bergmeier et al.   Channels

New insights into the pathogenesis of pancreatitis

(2013) Raghuwansh P. Sah et al.   CURRENT OPINION IN GASTROENTEROLOGY

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

(2013) SoHui Kim et al.   EMBO REPORTS

Irbit Mediates Synergy Between Ca 2+ and cAMP Signaling Pathways During Epithelial Transport in Mice

(2013) Seonghee Park et al.   GASTROENTEROLOGY

The STIM1 CTID domain determines access of SARAF to SOAR to regulate Orai1 channel function

(2013) Archana Jha et al.   JOURNAL OF CELL BIOLOGY

The role of Ca2+in the pathophysiology of pancreatitis

(2013) Julia V. Gerasimenko et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

(2013) Kenji Maeda et al.   NATURE

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

(2013) Sonia Sharma et al.   NATURE

Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy

(2013) J. V. Gerasimenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins

(2013) Junsen Tong et al.   STRUCTURE

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Feedback Regulation of Receptor-Induced Ca2+ Signaling Mediated by E-Syt1 and Nir2 at Endoplasmic Reticulum-Plasma Membrane Junctions

(2013) Chi-Lun Chang et al.   Cell Reports

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

(2012) Raz Palty et al.   CELL

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology

(2012) Andrew G. Manford et al.   DEVELOPMENTAL CELL

A conserved membrane-binding domain targets proteins to organelle contact sites

(2012) A. Toulmay et al.   JOURNAL OF CELL SCIENCE

Apical Ca2+-activated potassium channels in mouse parotid acinar cells

(2012) Janos Almassy et al.   JOURNAL OF GENERAL PHYSIOLOGY

Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

(2012) Patrick J. Shaw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial Ca2+ homeostasis: mechanism, role, and tissue specificities

(2012) Paola Pizzo et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion

(2012) Min Goo Lee et al.   PHYSIOLOGICAL REVIEWS

Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport

(2012) Kenneth B. Gagnon et al.   PHYSIOLOGICAL REVIEWS

Yeast Ist2 Recruits the Endoplasmic Reticulum to the Plasma Membrane and Creates a Ribosome-Free Membrane Microcompartment

(2012) Wendelin Wolf et al.   PLoS One

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

(2012) D. Willoughby et al.   Science Signaling

The closing and opening of TRPC channels by Homer1 and STIM1

(2011) J. P. Yuan et al.   Acta Physiologica

Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites

(2011) Christopher J. Stefan et al.   CELL

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Genetic and Pharmacologic Inhibition of the Ca2+ Influx Channel TRPC3 Protects Secretory Epithelia From Ca2+-Dependent Toxicity

(2011) Min Seuk Kim et al.   GASTROENTEROLOGY

A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

(2011) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

(2011) Maud de Saint-Jean et al.   JOURNAL OF CELL BIOLOGY

Ion channels in inflammation

(2011) Michael Eisenhut et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis

(2010) David I. Yule et al.   CELL CALCIUM

Extended-Synaptotagmin-2 Mediates FGF Receptor Endocytosis and ERK Activation In Vivo

(2010) Steve Jean et al.   DEVELOPMENTAL CELL

STIM1-dependent and STIM1-independent Function of Transient Receptor Potential Canonical (TRPC) Channels Tunes Their Store-operated Mode

(2010) Kyu Pil Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-dependent phospholipid scrambling by TMEM16F

(2010) Jun Suzuki et al.   NATURE

Store-operated CRAC channels: function in health and disease

(2010) Anant B. Parekh   NATURE REVIEWS DRUG DISCOVERY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

Polarized but Differential Localization and Recruitment of STIM1, Orai1 and TRPC Channels in Secretory Cells

(2010) Jeong Hee Hong et al.   TRAFFIC

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

Fatty acids, alcohol and fatty acid ethyl esters: Toxic Ca2+ signal generation and pancreatitis

(2009) O.H. Petersen et al.   CELL CALCIUM

Deletion of TRPC3 in Mice Reduces Store-Operated Ca2+ Influx and the Severity of Acute Pancreatitis

(2009) Min Seuk Kim et al.   GASTROENTEROLOGY

A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A signal comprising a basic cluster and an amphipathic  -helix interacts with lipids and is required for the transport of Ist2 to the yeast cortical ER

(2009) K. Maass et al.   JOURNAL OF CELL SCIENCE

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

(2009) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels

(2009) F. M. Mullins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression Cloning of TMEM16A as a Calcium-Activated Chloride Channel Subunit

(2008) Björn Christian Schroeder et al.   CELL

Stromal Interaction Molecule (STIM) 1 and STIM2 Calcium Sensing Regions Exhibit Distinct Unfolding and Oligomerization Kinetics

(2008) Peter B. Stathopulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMEM16A confers receptor-activated calcium-dependent chloride conductance

(2008) Young Duk Yang et al.   NATURE

TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

(2008) A. Caputo et al.   SCIENCE

Polarized Calcium Signaling in Exocrine Gland Cells

(2007) Ole H. Petersen et al.   Annual Review of Physiology