A longer isoform of Stim1 is a negative SOCE regulator but increases cAMP‐modulated NFAT signaling

The Orai Pore Opening Mechanism

(2021) Adéla Tiffner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SOCE in the cardiomyocyte: the secret is in the chambers

(2021) Paul Rosenberg et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry

(2021) Pulak Kar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A short isoform of STIM1 confers frequency-dependent synaptic enhancement

(2021) Girish Ramesh et al.   Cell Reports

STIM1 interacts with termini of Orai channels in a sequential manner

(2020) Liling Niu et al.   JOURNAL OF CELL SCIENCE

STIM2 targets Orai1/STIM1 to the AKAP79 signaling complex and confers coupling of Ca2+entry with NFAT1 activation

(2020) Ga-Yeon Son et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Molecular basis of allosteric Orai1 channel activation by STIM1

(2019) Priscilla See‐Wai Yeung et al.   JOURNAL OF PHYSIOLOGY-LONDON

Remodeling of ER–plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis

(2019) Fang Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

(2019) Xuexin Zhang et al.   Nature Communications

Detecting single ORAI1 proteins within the plasma membrane reveals higher-order channel complexes

(2019) Dalia Alansary et al.   JOURNAL OF CELL SCIENCE

The basic residues in the Orai1 channel inner pore promote opening of the outer hydrophobic gate

(2019) Megumi Yamashita et al.   JOURNAL OF GENERAL PHYSIOLOGY

STIM1 activation of adenylyl cyclase 6 connects Ca 2+ and cAMP signaling during melanogenesis

(2018) Rajender K Motiani et al.   EMBO JOURNAL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Red fluorescent cAMP indicator with increased affinity and expanded dynamic range

(2018) Yusaku Ohta et al.   Scientific Reports

Structures reveal opening of the store-operated calcium channel Orai

(2018) Xiaowei Hou et al.   eLife

Absolute Quantification of Major Photosynthetic Protein Complexes in Chlamydomonas reinhardtii Using Quantification Concatamers (QconCATs)

(2018) Alexander Hammel et al.   Frontiers in Plant Science

Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease

(2018) Antonio Michelucci et al.   CELL CALCIUM

UniProt: a worldwide hub of protein knowledge

(2018)   NUCLEIC ACIDS RESEARCH

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Authentic CRAC channel activity requires STIM1 and the conserved portion of the Orai N terminus

(2017) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ISA-2011B, a Phosphatidylinositol 4-Phosphate 5-Kinase α Inhibitor, Impairs CD28-Dependent Costimulatory and Pro-inflammatory Signals in Human T Lymphocytes

(2017) Martina Kunkl et al.   Frontiers in Immunology

The inactivation domain of STIM1 is functionally coupled with the Orai1 pore to enable Ca2+-dependent inactivation

(2016) Franklin M. Mullins et al.   JOURNAL OF GENERAL PHYSIOLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

The STIM1-binding site nexus remotely controls Orai1 channel gating

(2016) Yandong Zhou et al.   Nature Communications

Thiol dependent intramolecular locking of Orai1 channels

(2016) Dalia Alansary et al.   Scientific Reports

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

Ca2+ Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca2+-Dependent Nuclear Gene Expression

(2015) Krishna Samanta et al.   Cell Reports

Dynamic Assembly of a Membrane Signaling Complex Enables Selective Activation of NFAT by Orai1

(2014) Pulak Kar et al.   CURRENT BIOLOGY

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+Channel Orai1

(2012) Tatiana Kilch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating

(2010) Annette Lis et al.   JOURNAL OF GENERAL PHYSIOLOGY

Molecular Determinants of the Coupling between STIM1 and Orai Channels

(2009) Irene Frischauf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parathyroid Hormone Induction of Cyclooxygenase-2 in Murine Osteoblasts: Role of the Calcium-Calcineurin-NFAT Pathway

(2009) Hechang Huang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY