Cooperative Signaling via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin

IL-1β-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9

(2014) Qiaojia Huang et al.   Molecular Cancer

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

(2014) Chinnaswamy Tiruppathi et al.   NATURE IMMUNOLOGY

Store-operated Ca2+Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells through AMP-activated Protein Kinase and p38β Mitogen-activated Protein Kinase

(2013) Premanand C. Sundivakkam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation

(2013) Rajesh Kumar Gandhirajan et al.   JOURNAL OF CLINICAL INVESTIGATION

Critical Role of Non-Muscle Myosin Light Chain Kinase in Thrombin-Induced Endothelial Cell Inflammation and Lung PMN Infiltration

(2013) Fabeha Fazal et al.   PLoS One

Lipopolysaccharide Induces Endoplasmic Store Ca2+-Dependent Inflammatory Responses in Lung Microvessels

(2013) Kathirvel Kandasamy et al.   PLoS One

NF- B inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF- B in immune-mediated diseases

(2013) B. Sehnert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 Controls Endothelial Barrier Function Independently of Orai1 and Ca2+ Entry

(2013) A. V. Shinde et al.   Science Signaling

Immediate-early gene activation by the MAPK pathways: what do and don't we know?

(2012) Amanda O'Donnell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Regulation of NF-κB signaling by the A20 deubiquitinase

(2012) Noula Shembade et al.   Cellular & Molecular Immunology

Effective Treatment of Edema and Endothelial Barrier Dysfunction With Imatinib

(2012) Jurjan Aman et al.   CIRCULATION

Endothelial Nitric-oxide Synthase Activation Generates an Inducible Nitric-oxide Synthase-like Output of Nitric Oxide in Inflamed Endothelium

(2012) Jessica L. Lowry et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

(2012) Mohammad Tauseef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting of TAK1 in inflammatory disorders and cancer

(2012) Hiroaki Sakurai   TRENDS IN PHARMACOLOGICAL SCIENCES

The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment

(2011) Michael A. Matthay et al.   Annual Review of Pathology-Mechanisms of Disease

Transcription Factor NF-κB Regulates Expression of Pore-forming Ca2+Channel Unit, Orai1, and Its Activator, STIM1, to Control Ca2+Entry and Affect Cellular Functions

(2011) Anja Eylenstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

The p38 SAPK Is Recruited to Chromatin via Its Interaction with Transcription Factors

(2010) Isabel Ferreiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

An endoplasmic reticulum/plasma membrane junction: STIM1/Orai1/TRPCs

(2009) Kyu Pil Lee et al.   FEBS LETTERS

Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

(2008) Iskandar F. Abdullaev et al.   CIRCULATION RESEARCH

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STIM1 Gates TRPC Channels, but Not Orai1, by Electrostatic Interaction

(2008) Weizhong Zeng et al.   MOLECULAR CELL

Post-transcriptional control of cytokine production

(2008) Paul Anderson   NATURE IMMUNOLOGY