The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains

Structural elements of stromal interaction molecule function

(2018) Matthew J. Novello et al.   CELL CALCIUM

A charge-sensing region in the stromal interaction molecule 1 luminal domain confers stabilization-mediated inhibition of SOCE in response toS-nitrosylation

(2018) Jinhui Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels

(2018) Jill L. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-linking of Orai1 channels by STIM proteins

(2018) Yandong Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

(2018) Marc Fahrner et al.   Nature Communications

ATSAS 2.8: a comprehensive data analysis suite for small-angle scattering from macromolecular solutions

(2017) D. Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel

(2015) Jill L. Thompson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

(2015) Mate Maus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

Gain-of-Function Mutation in STIM1 (P.R304W) Is Associated with Stormorken Syndrome

(2014) Gilles Morin et al.   HUMAN MUTATION

A Dominant STIM1 Mutation Causes Stormorken Syndrome

(2014) Doriana Misceo et al.   HUMAN MUTATION

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

Initial activation of STIM1, the regulator of store-operated calcium entry

(2013) Yubin Zhou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Inhibitory Helix Controls the Intramolecular Conformational Switching of the C-Terminus of STIM1

(2013) Boyang Cui et al.   PLoS One

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

New developments in theATSASprogram package for small-angle scattering data analysis

(2012) Maxim V. Petoukhov et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools

(2011) N. Calloway et al.   JOURNAL OF CELL SCIENCE

Antiviral and Regulatory T Cell Immunity in a Patient with Stromal Interaction Molecule 1 Deficiency

(2011) S. Fuchs et al.   JOURNAL OF IMMUNOLOGY

Auto-inhibitory role of the EF-SAM domain of STIM proteins in store-operated calcium entry

(2011) L. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential Role for the CRAC Activation Domain in Store-dependent Oligomerization of STIM1

(2010) Elizabeth D. Covington et al.   MOLECULAR BIOLOGY OF THE CELL

A minimal regulatory domain in the C terminus of STIM1 binds to and activates ORAI1 CRAC channels

(2009) Takumi Kawasaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry

(2009) Ciara M. Walsh et al.   BIOCHEMICAL JOURNAL

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

DAMMIF, a program for rapidab-initioshape determination in small-angle scattering

(2009) Daniel Franke et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides

(2009) Marek K. Korzeniowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels

(2009) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Ca2+Release-activated Ca2+(CRAC) Modulatory Domain (CMD) within STIM1 Mediates Fast Ca2+-dependent Inactivation of ORAI1 Channels

(2009) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Short N-terminal Domains of STIM1 and STIM2 Control the Activation Kinetics of Orai1 Channels

(2009) Yandong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

Molecular determinants of fast Ca2+-dependent inactivation and gating of the Orai channels

(2009) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY