A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions

Cholesterol modulates Orai1 channel function

(2016) Isabella Derler et al.   Science Signaling

Cholesterol modulates Orai1 channel function

(2016) Isabella Derler et al.   Science Signaling

The ER/PM microdomain, PI(4,5)P2 and the regulation of STIM1–Orai1 channel function

(2015) Xu Cao et al.   CELL CALCIUM

Distinct Spatial Ca2+ Signatures Selectively Activate Different NFAT Transcription Factor Isoforms

(2015) Pulak Kar et al.   MOLECULAR CELL

Proteomic mapping of ER–PM junctions identifies STIMATE as a regulator of Ca2+ influx

(2015) Ji Jing et al.   NATURE CELL BIOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling

(2015) Ariel Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Translocation between PI(4,5)P2-poor and PI(4,5)P2-rich microdomains during store depletion determines STIM1 conformation and Orai1 gating

(2014) Jozsef Maléth et al.   Nature Communications

Cholesterol binding to ion channels

(2014) Irena Levitan et al.   Frontiers in Physiology

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

ER–PM connections: sites of information transfer and inter-organelle communication

(2013) Christopher J Stefan et al.   CURRENT OPINION IN CELL BIOLOGY

Coarse Architecture of the Transient Receptor Potential Vanilloid 1 (TRPV1) Ion Channel Determined by Fluorescence Resonance Energy Transfer

(2013) Víctor De-la-Rosa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Cholesterol Recognition Amino Acid Consensus Domain in GP64 Fusion Protein Facilitates Anchoring of Baculovirus to Mammalian Cells

(2013) A. Luz-Madrigal et al.   JOURNAL OF VIROLOGY

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

(2013) Sonia Sharma et al.   NATURE

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling

(2012) Hui Zheng et al.   BMC CELL BIOLOGY

Overexpression of Orai1 and STIM1 Proteins Alters Regulation of Store-operated Ca2+Entry by Endogenous Mediators

(2012) Tomasz Gwozdz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1)

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Platform for Combined DNA and Protein Microarrays Based on Total Internal Reflection Fluorescence

(2012) Alexander Asanov et al.   SENSORS

STIM Proteins and the Endoplasmic Reticulum-Plasma Membrane Junctions

(2011) Silvia Carrasco et al.   Annual Review of Biochemistry

Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T-cell activation

(2011) Ariel Quintana et al.   EMBO JOURNAL

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

(2011) Martin Muik et al.   EMBO JOURNAL

Selective Activation of the Transcription Factor NFAT1 by Calcium Microdomains near Ca2+Release-activated Ca2+(CRAC) Channels

(2011) Pulak Kar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools

(2011) N. Calloway et al.   JOURNAL OF CELL SCIENCE

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

A Basic Sequence in STIM1 Promotes Ca2+Influx by Interacting with the C-Terminal Acidic Coiled Coil of Orai1

(2010) Nathaniel Calloway et al.   BIOCHEMISTRY

Lipid rafts modulate the activation but not the maintenance of store-operated Ca2+ entry

(2010) Carmen Galan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Improved Probes for Hybrid Voltage Sensor Imaging

(2010) Dongsheng Wang et al.   BIOPHYSICAL JOURNAL

Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1

(2010) Isaac Jardin et al.   Channels

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells

(2010) Dylan M. Owen et al.   MOLECULAR MEMBRANE BIOLOGY

Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism

(2010) M. K. Korzeniowski et al.   Science Signaling

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

(2009) Chan Young Park et al.   CELL

SOAR and the polybasic STIM1 domains gate and regulate Orai channels

(2009) Joseph P. Yuan et al.   NATURE CELL BIOLOGY

STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum

(2009) L. Orci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1

(2009) B. Pani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteins and cholesterol-rich domains

(2008) Richard M. Epand   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: Moving TRPC1 in and out of lipid rafts

(2008) Sampieri Alicia et al.   CELL CALCIUM

Lipid Rafts Determine Clustering of STIM1 in Endoplasmic Reticulum-Plasma Membrane Junctions and Regulation of Store-operated Ca2+Entry (SOCE)

(2008) Biswaranjan Pani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Fluorescence Techniques Using Dehydroergosterol to Study Cholesterol Trafficking

(2008) Avery L. McIntosh et al.   LIPIDS

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Functional Implications of Plasma Membrane Condensation for T Cell Activation

(2008) Carles Rentero et al.   PLoS One

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation

(2008) M. I. Lioudyno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA