The Orai1 Store-operated Calcium Channel Functions as a Hexamer

Molecular mechanisms of STIM/Orai communication

(2016) Isabella Derler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels

(2016) Peiyao Li et al.   MOLECULAR BIOLOGY OF THE CELL

The STIM1-binding site nexus remotely controls Orai1 channel gating

(2016) Yandong Zhou et al.   Nature Communications

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Molecular Biophysics of Orai Store-Operated Ca2+ Channels

(2015) Anna Amcheslavsky et al.   BIOPHYSICAL JOURNAL

The STIM1–ORAI1 microdomain

(2015) Patrick G Hogan   CELL CALCIUM

Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating

(2015) Raz Palty et al.   CELL RESEARCH

Structural and Functional Mechanisms of CRAC Channel Regulation

(2015) Ann Hye-Ryong Shim et al.   JOURNAL OF MOLECULAR BIOLOGY

Calcium Signals Tune the Fidelity of Transcriptional Responses

(2015) Yandong Zhou et al.   MOLECULAR CELL

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+entry

(2015) Stefano Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding

(2015) Leidamarie Tirado-Lee et al.   PLoS One

Single-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum–plasma membrane junctions

(2014) Minnie M. Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

(2014) Aparna Gudlur et al.   Nature Communications

STIM proteins, Orai1, and gene expression

(2013) Pulak Kar et al.   Channels

The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1

(2013) Isabella Derler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C- and N-terminal STIM1 binding sites on Orai1 are required for both trapping and gating CRAC channels

(2013) Beth A. McNally et al.   JOURNAL OF PHYSIOLOGY-LONDON

Orai Channel Pore Properties and Gating by STIM: Implications from the Orai Crystal Structure

(2013) B. S. Rothberg et al.   Science Signaling

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

(2013) Peter B. Stathopulos et al.   Nature Communications

How Many Orai's Does It Take to Make a CRAC Channel?

(2013) Jill L. Thompson et al.   Scientific Reports

Gated regulation of CRAC channel ion selectivity by STIM1

(2012) Beth A. McNally et al.   NATURE

STIM proteins: dynamic calcium signal transducers

(2012) Jonathan Soboloff et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

Hypoxia-induced Acidosis Uncouples the STIM-Orai Calcium Signaling Complex

(2011) Salvatore Mancarella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1 senses both Ca2+ and heat

(2011) Salvatore Mancarella et al.   Nature Chemical Biology

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states

(2011) A. Demuro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

(2011) S. L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

Resting State Orai1 Diffuses as Homotetramer in the Plasma Membrane of Live Mammalian Cells

(2010) Josef Madl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pore architecture of the ORAI1 store-operated calcium channel

(2010) Y. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Calcium Store Sensor, STIM1, Reciprocally Controls Orai and CaV1.2 Channels

(2010) Y. Wang et al.   SCIENCE

Tetrameric Orai1 Is a Teardrop-shaped Molecule with a Long, Tapered Cytoplasmic Domain

(2009) Yuusuke Maruyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM protein coupling in the activation of Orai channels

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants of ion permeation in CRAC channels

(2009) Beth A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Orai1 Severe Combined Immune Deficiency Mutation and Calcium Release-activated Ca2+Channel Function in the Heterozygous Condition

(2008) Jill L. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

(2008) Martin Muik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

(2008) Aubin Penna et al.   NATURE

Functional stoichiometry of the unitary calcium-release-activated calcium channel

(2008) W. Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orai1 subunit stoichiometry of the mammalian CRAC channel pore

(2007) Olivier Mignen et al.   JOURNAL OF PHYSIOLOGY-LONDON