mTORC1 beyond anabolic metabolism: Regulation of cell death

Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting

(2022) Patrick Jouandin et al.   SCIENCE

Rapamycin ameliorates chronic intermittent hypoxia and sleep deprivation-induced renal damage via the mammalian target of rapamycin (mTOR)/NOD-like receptor protein 3 (NLRP3) signaling pathway

(2022) Wei Liu et al.   Bioengineered

Nucleotide biosynthesis links glutathione metabolism to ferroptosis sensitivity

(2022) Amy Tarangelo et al.   Life Science Alliance

mTOR substrate phosphorylation in growth control

(2022) Stefania Battaglioni et al.   CELL

Monitoring the induction of ferroptosis following dissociation in human embryonic stem cells

(2022) Shahnaz Babaei-Abraki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macropinocytosis is an alternative pathway of cysteine acquisition and mitigates sorafenib-induced ferroptosis in hepatocellular carcinoma

(2022) Jun-Kyu Byun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

(2022) Alessandra Fiore et al.   MOLECULAR CELL

Ferroptosis at the intersection of lipid metabolism and cellular signaling

(2022) Deguang Liang et al.   MOLECULAR CELL

The Mitochondrial Pathway of Apoptosis

(2022) Douglas R. Green   Cold Spring Harbor Perspectives in Biology

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

(2022) Pranavi Koppula et al.   Nature Communications

FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells

(2022) Huayuan Liu et al.   Frontiers in Oncology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

The Mitochondrial Pathway of Apoptosis Part II: The BCL-2 Protein Family

(2022) Douglas R. Green   Cold Spring Harbor Perspectives in Biology

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI

(2021) Chuan’ai Chen et al.   Cell Death & Disease

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Asah2 Represses the p53–Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis

(2021) Huabin Zhu et al.   JOURNAL OF IMMUNOLOGY

AIM2 in regulatory T cells restrains autoimmune diseases

(2021) Wei-Chun Chou et al.   NATURE

A compendium of kinetic modulatory profiles identifies ferroptosis regulators

(2021) Megan Conlon et al.   Nature Chemical Biology

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

(2021) Yilei Zhang et al.   Nature Communications

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

(2021) Margaret E Torrence et al.   eLife

TYRO3 induces anti–PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

(2021) Zhou Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells

(2021) Jiangwei Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

AMPK: restoring metabolic homeostasis over space and time

(2021) Elijah Trefts et al.   MOLECULAR CELL

SAR1B senses leucine levels to regulate mTORC1 signalling

(2021) Jie Chen et al.   NATURE

Molecular mechanisms of dietary restriction promoting health and longevity

(2021) Cara L. Green et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

(2021) Zengzhang Zheng et al.   SCIENCE

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

(2021) Daniel M. Kremer et al.   Nature Communications

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

(2021) Wen Liu et al.   Nature Communications

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

(2021) Delin Chen et al.   Nature Communications

The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

(2021) Ting Yuan et al.   Nature Communications

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

(2021) Shawn C. Chafe et al.   Science Advances

A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

(2021) Fushun Fan et al.   CANCER RESEARCH

GALNT14 regulates ferroptosis and apoptosis of ovarian cancer through the EGFR/mTOR pathway

(2021) Hua-wen Li et al.   Future Oncology

Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells

(2021) Yadong Sun et al.   Cell Death & Disease

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Glutamine and asparagine activate mTORC1 independently of Rag GTPases

(2020) Delong Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy-stress-mediated AMPK activation inhibits ferroptosis

(2020) Hyemin Lee et al.   NATURE CELL BIOLOGY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of Frataxin as a regulator of ferroptosis

(2020) Jing Du et al.   Redox Biology

Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

(2020) Mio Harachi et al.   MOLECULAR CANCER RESEARCH

PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells

(2020) Jinming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p21 can be a barrier to ferroptosis independent of p53

(2020) Divya Venkatesh et al.   Aging-US

Metabolism

(2020) Ayesha Judge et al.   Essays in Biochemistry

RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling

(2020) Deepika Sharma et al.   JOURNAL OF IMMUNOLOGY

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

(2020) Niklas Gremke et al.   Nature Communications

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

(2020) Yun Pyo Kang et al.   Cell Metabolism

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppression

(2020) Ning Kon et al.   GENES & DEVELOPMENT

Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis

(2020) Junmei Yi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer

(2020) Corrin A. Wohlhieter et al.   Cell Reports

HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications

(2020) Youbo Zhao et al.   Cell Reports

Differential Regulation of mTOR Complexes with miR-302a Attenuates Myocardial Reperfusion Injury in Diabetes

(2020) Arun Samidurai et al.   iScience

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program

(2019) Ji Heon Noh et al.   NUCLEIC ACIDS RESEARCH

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

(2019) Javier Garcia-Bermudez et al.   NATURE

Integration of nutrient, energy, light and hormone signalling via TOR in plants

(2019) Yue Wu et al.   JOURNAL OF EXPERIMENTAL BOTANY

Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury

(2019) Yuan Gui et al.   CELL DEATH AND DIFFERENTIATION

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

Metabolic regulation of cell growth and proliferation

(2019) Jiajun Zhu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

(2019) Boutaina Daher et al.   CANCER RESEARCH

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

Clockophagy is a novel selective autophagy process favoring ferroptosis

(2019) Minghua Yang et al.   Science Advances

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

(2019) Raquel Buj et al.   Cell Reports

NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice

(2019) Fabiola Marín‐Aguilar et al.   AGING CELL

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance

(2019) Yunseo Woo et al.   Journal of Oncology

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

miR-137 regulates ferroptosis by targeting glutamine transporter SLC1A5 in melanoma

(2018) Meiying Luo et al.   CELL DEATH AND DIFFERENTIATION

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

Cholesterol Peroxidation as a Special Type of Lipid Oxidation in Photodynamic Systems

(2018) Albert W. Girotti et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Interplay between YAP/TAZ and Metabolism

(2018) Ja Hyun Koo et al.   Cell Metabolism

AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity

(2018) Xinxin Song et al.   CURRENT BIOLOGY

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Phospholipase D-Dependent mTORC1 Activation by Glutamine

(2018) Elyssa Bernfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trafficking of cholesterol to the ER is required for NLRP3 inflammasome activation

(2018) Marianne de la Roche et al.   JOURNAL OF CELL BIOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

(2017) Shin-ichi Oka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis

(2017) Wei Wan et al.   MOLECULAR CELL

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Marked for death: targeting epigenetic changes in cancer

(2017) Sophia Xiao Pfister et al.   NATURE REVIEWS DRUG DISCOVERY

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

(2017) Victor H. Villar et al.   Nature Communications

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

(2017) Natasha Emmanuel et al.   Cell Reports

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine

(2017) Ioannis Poursaitidis et al.   Cell Reports

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

(2017) Laura Formentini et al.   Cell Reports

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

(2017) Gerta Hoxhaj et al.   Cell Reports

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

PI3K/AKT/mTOR Signaling Mediates Valproic Acid-Induced Neuronal Differentiation of Neural Stem Cells through Epigenetic Modifications

(2017) Xi Zhang et al.   Stem Cell Reports

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

The mTOR signalling cascade: paving new roads to cure neurological disease

(2016) Peter B. Crino   Nature Reviews Neurology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

(2016) I. Ben-Sahra et al.   SCIENCE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Quantitative phosphoproteomics reveals the role of the AMPK plant ortholog SnRK1 as a metabolic master regulator under energy deprivation

(2016) Ella Nukarinen et al.   Scientific Reports

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

Crosstalk between cystine and glutathione is critical for the regulation of amino acid signaling pathways and ferroptosis

(2016) Xinlei Yu et al.   Scientific Reports

HSPA12B Attenuated Acute Myocardial Ischemia/reperfusion Injury via Maintaining Endothelial Integrity in a PI3K/Akt/mTOR-dependent Mechanism

(2016) Qiuyue Kong et al.   Scientific Reports

Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway

(2015) Fu-Zheng Wei et al.   Autophagy

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

(2015) Jiangbin Ye et al.   GENES & DEVELOPMENT

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

(2015) Jinbo Han et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols

(2015) Aubérie Parent et al.   Nature Communications

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast

(2015) James E Hughes Hallett et al.   eLife

Human Frataxin Activates Fe–S Cluster Biosynthesis by Facilitating Sulfur Transfer Chemistry

(2014) Jennifer Bridwell-Rabb et al.   BIOCHEMISTRY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

(2014) Chen-Song Zhang et al.   Cell Metabolism

Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death

(2014) Shakeel U. R. Mir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Mammalian iron–sulphur proteins: novel insights into biogenesis and function

(2014) Tracey A. Rouault   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Self-consumption: the interplay of autophagy and apoptosis

(2014) Guillermo Mariño et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo

(2014) Maximilian Kleinert et al.   Molecular Metabolism

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

(2013) O. Meynet et al.   BLOOD

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation

(2013) Ya-Lin Zhang et al.   Cell Metabolism

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

(2013) Orly Weinreb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Stabilizes ISCU Protein

(2013) Ping La et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor  

(2013) H. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

(2013) Morgan D Fullerton et al.   NATURE MEDICINE

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

(2012) J. L. Owen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress

(2011) Shukie Ng et al.   Autophagy

Ornithine decarboxylase mRNA is stabilized in an mTORC1-dependent manner in Ras-transformed cells

(2011) Sofia Origanti et al.   BIOCHEMICAL JOURNAL

Defective Regulation of Autophagy upon Leucine Deprivation Reveals a Targetable Liability of Human Melanoma Cells In Vitro and In Vivo

(2011) Joon-Ho Sheen et al.   CANCER CELL

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

p38α Mediates Cell Survival in Response to Oxidative Stress via Induction of Antioxidant Genes

(2011) Álvaro Gutiérrez-Uzquiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3−/− mice

(2010) Safak Yalcin et al.   EMBO JOURNAL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation

(2009) L A Pradelli et al.   ONCOGENE

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL