Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 10, Pages 6071-6085
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2014-12-30
DOI
10.1074/jbc.m114.605345
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Utilizing flow cytometry to monitor autophagy in living mammalian cells
- (2014) Elena Shvets et al. Autophagy
- Pancreatic -Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
- (2014) A. Bartolome et al. DIABETES
- Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes
- (2014) Jinyoung Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy
- (2014) Nayumi Shigihara et al. JOURNAL OF CLINICAL INVESTIGATION
- Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
- (2014) Jacqueline F. Rivera et al. JOURNAL OF CLINICAL INVESTIGATION
- RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate
- (2013) Miriam Cnop et al. DIABETES
- Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death
- (2012) Alberto Bartolome et al. Autophagy
- Guidelines for the use and interpretation of assays for monitoring autophagy
- (2012) Daniel J. Klionsky et al. Autophagy
- Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes
- (2012) E. Bachar-Wikstrom et al. DIABETES
- Neutrophil Gelatinase-associated Lipocalin (NGAL) Expression Is Dependent on the Tumor-associated Sigma-2 Receptor S2RPgrmc1
- (2012) Shakeel U. R. Mir et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Feedback on Fat: p62-mTORC1-Autophagy Connections
- (2011) Jorge Moscat et al. CELL
- Autophagy deficiency in beta cells leads to compromised unfolded protein response and progression from obesity to diabetes in mice
- (2011) W. Quan et al. DIABETOLOGIA
- The dynamic nature of autophagy in cancer
- (2011) A. C. Kimmelman GENES & DEVELOPMENT
- Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients
- (2011) Shakeel U.R. Mir et al. INTERNATIONAL JOURNAL OF CANCER
- Fatty Acids Suppress Autophagic Turnover in β-Cells
- (2011) Guy Las et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1
- (2011) Maki Koyanagi et al. PLoS One
- The emerging role of autophagy in the pathophysiology of diabetes mellitus
- (2010) Claudio D. Gonzalez et al. Autophagy
- LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation
- (2010) Masahiro Shibata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations
- (2010) Hsiuchen Chen et al. CELL
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
- (2010) Gökhan S. Hotamisligil CELL
- Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
- (2010) Ling Yang et al. Cell Metabolism
- Decreased IRS Signaling Impairs -Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in -Cells
- (2010) L. Elghazi et al. DIABETES
- Altered lipid content inhibits autophagic vesicular fusion
- (2010) Hiroshi Koga et al. FASEB JOURNAL
- Network organization of the human autophagy system
- (2010) Christian Behrends et al. NATURE
- LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
- (2009) R. J. Shaw Acta Physiologica
- Lipid oversupply, selective insulin resistance, and lipotoxicity: Molecular mechanisms
- (2009) Jose Antonio Chavez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- As a Matter of Fat
- (2009) Rita T. Brookheart et al. Cell Metabolism
- Autophagy in human type 2 diabetes pancreatic beta cells
- (2009) M. Masini et al. DIABETOLOGIA
- Autophagy regulates lipid metabolism
- (2009) Rajat Singh et al. NATURE
- Autophagy: Basic Principles and Relevance to Disease
- (2008) Mondira Kundu et al. Annual Review of Pathology-Mechanisms of Disease
- Autophagy in the Pathogenesis of Disease
- (2008) Beth Levine et al. CELL
- Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia
- (2008) Hye Seung Jung et al. Cell Metabolism
- Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet
- (2008) Chie Ebato et al. Cell Metabolism
- mTOR Inhibition by Rapamycin Prevents -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
- (2008) M. Fraenkel et al. DIABETES
- Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death
- (2008) Sung-E Choi et al. ENDOCRINOLOGY
- Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
- (2008) Umut Ozcan et al. MOLECULAR CELL
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started