Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production

(2016) Walter A. Baseler et al.   Redox Biology

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Metabolic Regulation of Immune Responses

(2014) Kirthana Ganeshan et al.   Annual Review of Immunology

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

Macrophage-Restricted Interleukin-10 Receptor Deficiency, but Not IL-10 Deficiency, Causes Severe Spontaneous Colitis

(2014) Ehud Zigmond et al.   IMMUNITY

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Inhibition Extends Cellular Lifespan in Dendritic Cells by Preserving Mitochondrial Function

(2014) Eyal Amiel et al.   JOURNAL OF IMMUNOLOGY

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

(2014) M. D. Dennis et al.   Science Signaling

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

(2012) B. Everts et al.   BLOOD

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production

(2012) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice

(2012) E. Amiel et al.   JOURNAL OF IMMUNOLOGY

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice

(2012) Namiko Hoshi et al.   Nature Communications

Defective IL10 Signaling Defining a Subgroup of Patients With Inflammatory Bowel Disease

(2011) Bernadette Begue et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease

(2011) Wenjun Ouyang et al.   Annual Review of Immunology

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

(2009) Michal Caspi Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS