Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Adipocyte-induced FABP4 expression in ovarian cancer cells promotes metastasis and mediates carboplatin resistance

(2020) Abir Mukherjee et al.   CANCER RESEARCH

Metabolic Plasticity in Chemotherapy Resistance

(2020) Maria Andrea Desbats et al.   Frontiers in Oncology

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

FABP4: A New Player in Obesity-Associated Breast Cancer

(2020) Jun Zeng et al.   TRENDS IN MOLECULAR MEDICINE

Statin use and breast cancer recurrence in postmenopausal women treated with adjuvant aromatase inhibitors: a Danish population-based cohort study

(2020) Sixten Harborg et al.   BREAST CANCER RESEARCH AND TREATMENT

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Statin use and breast cancer survival – a Swedish nationwide study

(2019) Signe Borgquist et al.   BMC CANCER

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

(2019) Luca Lignitto et al.   CELL

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Adipocyte and lipid metabolism in cancer drug resistance

(2019) Yihai Cao   JOURNAL OF CLINICAL INVESTIGATION

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

(2019) William W. Feng et al.   Cell Reports

Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer

(2019) Jonas Steenbrugge et al.   Frontiers in Immunology

Anti-insulin-like growth factor therapy in breast cancer

(2018) Douglas Yee   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Obesity and breast cancer – Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue

(2018) Céline Gérard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells

(2018) Barbara Lettiero et al.   Scientific Reports

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer

(2017) Siker Kimbung et al.   ENDOCRINE-RELATED CANCER

Cholesterol, Cholesterol-Lowering Medication Use, and Breast Cancer Outcome in the BIG 1-98 Study

(2017) Signe Borgquist et al.   JOURNAL OF CLINICAL ONCOLOGY

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

(2017) Samantha W. Alvarez et al.   NATURE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

(2017) Brian M. Castellano et al.   SCIENCE

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

(2017) Amy E. Baek et al.   Nature Communications

Membrane cholesterol access into a G-protein-coupled receptor

(2017) Ramon Guixà-González et al.   Nature Communications

The Role of Cholesterol in Cancer

(2016) Omer F. Kuzu et al.   CANCER RESEARCH

Metastasis Stimulation by Hypoxia and Acidosis-Induced Extracellular Lipid Uptake Is Mediated by Proteoglycan-Dependent Endocytosis

(2016) J. A. Menard et al.   CANCER RESEARCH

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Shared Risk Factors in Cardiovascular Disease and Cancer

(2016) Ryan J. Koene et al.   CIRCULATION

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta-analysis

(2016) Sashidhar Manthravadi et al.   INTERNATIONAL JOURNAL OF CANCER

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Statin use and mortality in cancer patients: Systematic review and meta-analysis of observational studies

(2015) Shanliang Zhong et al.   CANCER TREATMENT REVIEWS

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Obesity and cancer, a case for insulin signaling

(2015) Y Poloz et al.   Cell Death & Disease

Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion

(2015) Van T. M. Nguyen et al.   Nature Communications

Statin use and breast cancer survival and risk: a systematic review and meta-analysis

(2015) Qi-Jun Wu et al.   Oncotarget

Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR

(2015) Linara Gabitova et al.   Cell Reports

Hyperlipidemia and cardiovascular disease

(2014) Uwe J.F. Tietge   CURRENT OPINION IN LIPIDOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

(2014) Ren Sheng et al.   Nature Communications

Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients

(2013) S. Jiralerspong et al.   ANNALS OF ONCOLOGY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

(2013) E. R. Nelson et al.   SCIENCE

27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

(2013) Qian Wu et al.   Cell Reports

Statin use and risk of breast cancer: a meta-analysis of observational studies

(2012) Krishna Undela et al.   BREAST CANCER RESEARCH AND TREATMENT

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Cholesterol and breast cancer development

(2012) Christiane Danilo et al.   CURRENT OPINION IN PHARMACOLOGY

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

(2011) C. Cai et al.   CANCER RESEARCH

The Oxysterol, 27-Hydroxycholesterol, Links Cholesterol Metabolism to Bone Homeostasis Through Its Actions on the Estrogen and Liver X Receptors

(2011) Erik R. Nelson et al.   ENDOCRINOLOGY

Statin Prescriptions and Breast Cancer Recurrence Risk: A Danish Nationwide Prospective Cohort Study

(2011) T. P. Ahern et al.   JNCI-Journal of the National Cancer Institute

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism

(2010) Ratna Karuna et al.   ATHEROSCLEROSIS

Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to β-catenin in different cancers

(2010) Lei He et al.   BMC CANCER

Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis

(2010) Alina Vrieling et al.   BREAST CANCER RESEARCH AND TREATMENT

Evidence of Limited Contributions for Intratumoral Steroidogenesis in Prostate Cancer

(2010) J. Hofland et al.   CANCER RESEARCH

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

HDL-Cholesterol and Incidence of Breast Cancer in the ARIC Cohort Study

(2008) Anna M. Kucharska-Newton et al.   ANNALS OF EPIDEMIOLOGY