Article
Pharmacology & Pharmacy
Xingrong Lai, Yanhua Sun, Xuedi Zhang, Dan Wang, Jialing Wang, Haihua Wang, Yao Zhao, Xinling Liu, Xin Xu, Haoran Song, Wenjia Ping, Yanli Sun, Zhenbo Hu
Summary: Honokiol is an effective anti-leukemia agent that reduces the viability of AML cells and induces cell cycle arrest. It triggers a noncanonical ferroptosis pathway by upregulating intracellular lipid peroxide and HMOX1 levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Haiyingjie Lin, Xiaoting Chen, Chengyong Zhang, Tingting Yang, Zhendong Deng, Yuwei Song, Lanlan Huang, Fuxiang Li, Qingchu Li, Shaoqiang Lin, Dadi Jin
Summary: EF24 can induce ferroptosis in osteosarcoma cells by upregulating HMOX1 to suppress GPX4 expression, increasing MDA level, ROS level and intracellular ferric ion level. It may serve as a potential agent for the treatment of HMOX1-positive osteosarcoma patients.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Yue Qiu, Yirui Cao, Guowei Tu, Jiawei Li, Ying Su, Fang Fang, Xuepeng Zhang, Jing Cang, Ruiming Rong, Zhe Luo
Summary: The study demonstrated that MDSCs can significantly alleviate renal fibrosis by promoting the interaction of the CCL5-CCR5 axis and inhibiting the TGF-beta 1/Smad/Snail signaling pathway. This leads to enhanced infiltration of MDSCs and Treg in the kidney, while reducing the levels of T(H)1 cells. The findings suggest an alternative treatment approach for renal fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Omori, Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Masahiro Umeda, Kosei Ito
Summary: Osteosarcoma is a disease in humans characterized by TP53 mutations. In mice, loss of p53 triggers OS development, and osteoprogenitor-specific p53-deleted mice are widely used to study the process of osteosarcomagenesis. However, the molecular mechanisms underlying the initiation or progression of OS following or parallel to p53 inactivation remain largely unknown. This study reveals a novel tumor suppressive mechanism mediated by C/ebp alpha in p53-deficient osteosarcomagenesis, highlighting the importance of the Runx-Myc oncogenic axis as a therapeutic target for OS.
Article
Immunology
Mengyi Shen, Xiaoli Fan, Yi Shen, Xiaoze Wang, Ruiqi Wu, Yi Wang, Chen Huang, Shenglan Zhao, Yanyi Zheng, Ruoting Men, Xuefeng Luo, Li Yang
Summary: The study investigated the efficacy and safety of myeloid-derived suppressor cells (MDSCs) in protecting against autoimmune hepatitis (AIH) and found that MDSCs ameliorate liver mitochondrial damage by releasing small extracellular vesicles, thus protecting the body from AIH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Haixia Ji, Wenzhe Wang, Xia Li, Xiaoying Han, Xinyu Zhang, Juan Wang, Changxiao Liu, Luqi Huang, Wenyuan Gao
Summary: This review discusses the role of the p53 gene in regulating ferroptosis, primarily through influencing metabolic networks and signaling pathways that affect tumor cell sensitivity to ferroptosis. This has important implications for further understanding the role of p53 in tumor ferroptosis and developing new strategies for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Tianhao Ren, Ju Huang, Wei Sun, Guangze Wang, Yuwen Wu, Zewei Jiang, Yingshuai Lv, Guang Wu, Jiawei Cao, Min Liu, Haihua Gu
Summary: Zoledronic acid inhibits the growth of osteosarcoma cells by inducing ferroptosis through decreasing ubiquinone content and promoting HMOX1 expression. Combining zoledronic acid with a ferroptosis inducer may be a promising new strategy for the treatment of osteosarcoma.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Zeyu Wang, Weijian Li, Xue Wang, Qin Zhu, Liguo Liu, Shimei Qiu, Lu Zou, Ke Liu, Guoqiang Li, Huijie Miao, Yang Yang, Chengkai Jiang, Yong Liu, Rong Shao, Xu'an Wang, Yingbin Liu
Summary: The study found that natural compound Isoliquiritigenin (ISL) can induce ferroptosis in gallbladder cancer by activating a specific signaling pathway. This discovery provides a new approach for the treatment of gallbladder cancer.
CHINESE MEDICAL JOURNAL
(2023)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Iosif Papafragkos, Efrosyni Markaki, Christina Kalpadakis, Panayotis Verginis
Summary: Myeloid-derived suppressor cells (MDSCs) are potent regulators of the immune system, playing a role in cancer but their specific contribution to lymphomas remains unclear. This review focuses on MDSCs in lymphomas, discussing literature and lessons learned from animal models, and highlights future research directions and challenges in understanding the immune system complexities in malignancies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Estefania Prochetto, Eliana Borgna, Carlos Jimenez-Cortegana, Victor Sanchez-Margalet, Gabriel Cabrera
Summary: Myeloid-derived suppressor cells (MDSCs) play a role in both pathological and non-pathological conditions, including cancer, infections, pregnancy, aging, and vaccination. Vaccination is a crucial public health measure, but the presence of MDSCs may impact vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Immunology
Taosan Li, Fang Zheng, Fanjun Cheng
Summary: This article analyzes the role of MDSCs in lymphopenia in COVID-19 patients and discusses their immunopathologic changes and potential therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Varghese, Farihah Haque, Wei Lu, Mark W. Grinstaff
Summary: Polysaccharides play an important role in biomedical applications, but their preparation faces challenges. This study presents a synthetic strategy to regioselectively functionalize polysaccharides using post-polymerization modification reactions. This new method provides a new approach for obtaining functional polysaccharide mimetics for biomedical applications.
Article
Engineering, Biomedical
Robert C. Sabatelle, Rong Liu, Yin P. Hung, Eric Bressler, Eliza J. Neal, Andrew Martin, Iriny Ekladious, Mark W. Grinstaff, Yolonda L. Colson
Summary: Peritoneal mesothelioma is an aggressive disease with poor treatment options. A study shows that ultra-high drug loaded nanoparticles can improve survival rate and prolonged local drug delivery can further enhance overall survival.
Article
Anatomy & Morphology
Deva D. Chan, Maleeha Mashiatulla, Jun Li, Ryan D. Ross, Meghana Pendyala, Amit Patwa, Mark W. Grinstaff, Anna Plaas, D. Rick Sumner
Summary: This study uses contrast-enhanced micro-computed tomography to track the spatiotemporal patterns of cartilage and bone degeneration in a mouse model of osteoarthritis. The findings provide important insights for the development of targeted therapies for osteoarthritis.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Aaron H. Colby, Jack Kirsch, Amit N. Patwa, Rong Liu, Beth Hollister, William McCulloch, Joanna E. Burdette, Cedric J. Pearce, Nicholas H. Oberliels, Yolonda L. Colson, Kebin Liu, Mark W. Grinstaff
Summary: The distribution of fluorescently labeled expansile nanoparticles (eNPs) in vivo is crucial for the success of nanoparticle-based drug delivery systems. Quantitative evaluation of eNPs' biodistribution in a murine model of intraperitoneal mesothelioma was conducted using synthesized 14C-labeled eNPs and liquid scintillation counting. The results showed a strong tumor specificity of eNPs, with an overall delivery efficiency of 30% to the tumor tissue, which is higher than other nanoparticle delivery systems. Administration routes had a significant impact on eNPs' targeting strategy, with intraperitoneal administration leading to tumor accumulation while intravenous administration resulted in rapid clearance and low tumor accumulation. These findings lay the foundation for targeting intraperitoneal tumors and exploring alternative delivery routes for nanoparticle therapies.
Article
Cardiac & Cardiovascular Systems
Lillian L. Tsai, Danielle M. Fitzgerald, Rong Liu, Jenny T. Korunes-Miller, Eliza Neal, Yin P. Hung, Samantha Bilton, Aaron Hata, Mark W. Grinstaff, Yolonda L. Colson
Summary: A PDX surgical resection model of non-small cell lung cancer was established in mice, and it was found that intraoperative placement of drug-loaded meshes significantly improved local disease treatment, suggesting a potential improvement in recurrence-free survival for early-stage non-small cell lung cancer patients.
ANNALS OF THORACIC SURGERY
(2023)
Article
Materials Science, Biomaterials
Ismail Altinbasak, Salli Kocak, Aaron H. Colby, Yasin Alp, Rana Sanyal, Mark W. Grinstaff, Amitav Sanyal
Summary: Electrospun nanofibers have numerous advantages as a scaffold for drug delivery devices. A new pH-responsive nanofiber buttress was synthesized via electrospinning. The buttress transforms from a hydrophobic to a hydrophilic state under relevant pH conditions and releases the encapsulated drug. It shows controlled drug release and cytotoxicity to cancer cells.
BIOMATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Danielle M. Fitzgerald, Yolonda L. Colson, Mark W. Grinstaff
Summary: Pressure-sensitive adhesives, commonly found in households, have various applications in everyday life. With advancements in material and polymer science, these adhesives are transitioning from commodity to specialty materials, leading to new clinical uses and improved patient care.
NATURE REVIEWS MATERIALS
(2023)
Article
Multidisciplinary Sciences
Jialiu Zeng, Rebeca Acin-Perez, Essam A. Assali, Andrew Martin, Alexandra J. Brownstein, Anton Petcherski, Lucia Fernandez-del-Rio, Ruiqing Xiao, Chih Hung Lo, Michael Shum, Marc Liesa, Xue Han, Orian S. Shirihai, Mark W. Grinstaff
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. This study synthesizes acid-activated acidifying nanoparticles to restore lysosomal function and reverse fasting hyperglycemia and hepatic steatosis in NAFLD. In high fat diet mouse models, treatment with these nanoparticles restores autophagy and mitochondrial function to lean, healthy levels, showing the potential therapeutic use for NAFLD.
NATURE COMMUNICATIONS
(2023)
Review
Polymer Science
Xingyu Hu, Mark W. Grinstaff
Summary: Millions of individuals undergo gastrointestinal (GI) tract surgeries each year, which often lead to complications such as bleeding, perforation, leakage, and infection. Hydrogel adhesives have shown promise in treating GI tract wounds due to their atraumatic nature, sealing capability, healing properties, and ease of use. However, challenges such as weak underwater adhesive strength and slow gelation need to be addressed. This review summarizes recent advancements in hydrogel adhesives for GI tract wounds, focusing on material designs and compositions to overcome the specific challenges posed by GI injuries.
Article
Biochemistry & Molecular Biology
Chloe Grazon, Elisabeth Garanger, Pierre Lalanne, Emmanuel Ibarboure, James E. Galagan, Mark W. Grinstaff, Sebastien Lecommandoux
Summary: Polymeric micelles based on natural diblocks, such as elastin-like polypeptide (ELP) and oligonucleotide (ON), have advantageous properties in terms of molecular recognition, biocompatibility, and biodegradability. This study reports a straightforward synthesis of ON-b-ELP diblock bioconjugates through copper-catalyzed azide-alkyne cycloaddition. The resulting micelles self-assemble above their critical micelle temperature (CMT) to form stable structures, and they retain their stability and temperature sensitivity when binding with proteins.
Article
Orthopedics
Heta Orava, Petri Paakkari, Jiri Jantti, Miitu K. M. Honkanen, Juuso T. J. Honkanen, Tuomas Viren, Anisha Joenathan, Petri Tanska, Rami K. Korhonen, Mark W. Grinstaff, Juha Toyras, Janne T. A. Makela
Summary: In this study, a triple contrast agent was used to image and segment cadaveric knee joints in CT. The results showed that large BiNPs do not diffuse into cartilage, facilitating straightforward segmentation. The concentration of CA4+ was significantly higher in femoral cartilage than in tibial cartilage, corresponding to the biomechanical differences observed. This suggests that triple contrast agent CT has potential for assessing cartilage morphology and condition in a clinical setting.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Polymer Science
Danielle M. Fitzgerald, Yolonda L. Colson, Mark W. Grinstaff
Summary: Pressure sensitive adhesives are widely used in everyday products and have the potential for greater use in medicine. The strength of adhesion depends on the chemical and material properties of the adhesive formulation and its interaction with the surface. This review focuses on the structure-property relationships of polymer architecture and pressure sensitive adhesion, specifically in the context of durable, removable, and biocompatible adhesion to wet surfaces like tissue. Challenges in biomedical wound closure are also discussed, along with innovative strategies to address them.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Polymer Science
Danielle M. M. Fitzgerald, Heng Zhang, Catalina Bordeianu, Yolonda L. L. Colson, Mark W. W. Grinstaff
Summary: This study describes the synthesis of mPEG-b-PGC block copolymers using a cobaltsalen catalyst via the ring-opening polymerization of benzyl glycidyl ether, monomethoxylated polyethylene glycol, and carbon dioxide. The resulting block copolymers exhibit high polymer/cyclic carbonate selectivity (>99%) and random incorporation of oxirane monomers. The diblock mPEG-b-PGC polymer shows promise as a nanocarrier for sustained chemotherapeutic delivery without the need for surfactants.
Review
Oncology
Eric M. Bressler, Sarah Adams, Rong Liu, Yolonda L. Colson, Wilson W. Wong, Mark W. Grinstaff
Summary: The intersection of synthetic biology and biomaterials holds great promise for improving safety and efficacy in novel therapeutics. Recent research has shown that the use of Boolean logic in these fields can lead to the development of new and effective living therapeutics, such as stimuli-responsive drug delivery devices and logic-gated CAR T cells. Collaborations between synthetic biology and biomaterials have resulted in advancements in drug delivery and cell therapy, with potential benefits including enhanced safety and efficacy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Sue Zhang, Kathryn Regan, Julian Najera, Mark W. Grinstaff, Meenal Datta, Hadi T. Nia
Summary: Cancer initiation and progression lead to significant changes in the microenvironment at the interface between healthy and malignant tissue, known as the peritumor. The peritumor is characterized by unique physical and immune attributes, which contribute to tumor progression through interconnected mechanical signaling and immune activity. Understanding and targeting the biomarkers and therapeutic targets in the peritumor is crucial for future cancer research and clinical advancements, particularly in overcoming resistance to immunotherapy.