- Home
- Publications
- Publication Search
- Publication Details
Title
Marked for death: targeting epigenetic changes in cancer
Authors
Keywords
-
Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 16, Issue 4, Pages 241-263
Publisher
Springer Nature
Online
2017-03-10
DOI
10.1038/nrd.2016.256
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
- (2016) Anna C. Groner et al. CANCER CELL
- Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development
- (2016) Rui Lu et al. CANCER CELL
- G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status
- (2016) Pallavi Agarwal et al. CANCER LETTERS
- A Landscape of Pharmacogenomic Interactions in Cancer
- (2016) Francesco Iorio et al. CELL
- Dual Chromatin and Cytoskeletal Remodeling by SETD2
- (2016) In Young Park et al. CELL
- HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma
- (2016) Hong Zheng et al. CLINICAL CANCER RESEARCH
- High rate of complete responses to immune checkpoint inhibitors in patients with relapsed or refractory Hodgkin lymphoma previously exposed to epigenetic therapy
- (2016) Lorenzo Falchi et al. Journal of Hematology & Oncology
- MAGE-C2–Specific TCRs Combined with Epigenetic Drug-Enhanced Antigenicity Yield Robust and Tumor-Selective T Cell Responses
- (2016) Andre Kunert et al. JOURNAL OF IMMUNOLOGY
- Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2
- (2016) Erik Eggert et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates
- (2016) Hazem Ahmed et al. JOURNAL OF PROTEOME RESEARCH
- Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics
- (2016) Jonathan B. Olsen et al. MOLECULAR & CELLULAR PROTEOMICS
- Synthetic Lethal Targeting of ARID1A -Mutant Ovarian Clear Cell Tumors with Dasatinib
- (2016) Rowan E. Miller et al. MOLECULAR CANCER THERAPEUTICS
- Bet on drug resistance
- (2016) Jeff Settleman NATURE
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
- (2016) Marco Sciacovelli et al. NATURE
- Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
- (2016) Shaokun Shu et al. NATURE
- An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells
- (2016) Maia Vinogradova et al. Nature Chemical Biology
- Targeting EZH2 in cancer
- (2016) Kimberly H Kim et al. NATURE MEDICINE
- Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
- (2016) Konstantinos J. Mavrakis et al. SCIENCE
- MTAPdeletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
- (2016) Gregory V. Kryukov et al. SCIENCE
- The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas
- (2016) D. Fang et al. SCIENCE
- Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
- (2016) Yujing Xiong et al. Stem Cell Reviews and Reports
- The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
- (2016) Mélissa Carbonneau et al. Nature Communications
- The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
- (2016) Bernard Pereira et al. Nature Communications
- ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
- (2016) Chris T. Williamson et al. Nature Communications
- Lifting Up the HAT: Synthetic Lethal Screening Reveals a Novel Vulnerability at the CBP-p300 Axis
- (2016) C. Kadoch Cancer Discovery
- BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression
- (2016) Hengrui Zhu et al. Cell Reports
- MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis
- (2016) Katya Marjon et al. Cell Reports
- Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation
- (2016) Yujing Xiong et al. Stem Cell Reviews and Reports
- Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer
- (2016) Yuanhui Jia et al. Cell Discovery
- Aging and DNA methylation
- (2015) Marc Jung et al. BMC BIOLOGY
- A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
- (2015) Helai P. Mohammad et al. CANCER CELL
- Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation
- (2015) Sophia X. Pfister et al. CANCER CELL
- PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer
- (2015) Nisha Nagarsheth et al. CANCER RESEARCH
- The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies
- (2015) Bhavatarini Vangamudi et al. CANCER RESEARCH
- DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
- (2015) David Roulois et al. CELL
- Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
- (2015) Katherine B. Chiappinelli et al. CELL
- The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond
- (2015) Nicole Stopa et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma
- (2015) H.-Z. Lee et al. CLINICAL CANCER RESEARCH
- Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
- (2015) M. C. Caino et al. CLINICAL CANCER RESEARCH
- Histo-genomic stratification reveals the frequent amplification/overexpression ofCCNE1andBRD4genes in non-BRCAness high grade ovarian carcinoma
- (2015) Oumou Goundiam et al. INTERNATIONAL JOURNAL OF CANCER
- BRD4 promotes tumor growth and epithelial-mesenchymal transition in hepatocellular carcinoma
- (2015) Pengfei Zhang et al. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
- LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2
- (2015) Hannah Nguyen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone Deacetylase Inhibitors in Clinical Studies as Templates for New Anticancer Agents
- (2015) Madhusoodanan Mottamal et al. MOLECULES
- Non-coding recurrent mutations in chronic lymphocytic leukaemia
- (2015) Xose S. Puente et al. NATURE
- Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy
- (2015) Dongjun Peng et al. NATURE
- Transcriptional plasticity promotes primary and acquired resistance to BET inhibition
- (2015) Philipp Rathert et al. NATURE
- BET inhibitor resistance emerges from leukaemia stem cells
- (2015) Chun Yew Fong et al. NATURE
- Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
- (2015) Junwei Shi et al. NATURE BIOTECHNOLOGY
- What are super-enhancers?
- (2015) Sebastian Pott et al. NATURE GENETICS
- SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
- (2015) Kimberly H Kim et al. NATURE MEDICINE
- SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets
- (2015) Jing Guo et al. NUCLEIC ACIDS RESEARCH
- Gene essentiality and synthetic lethality in haploid human cells
- (2015) V. A. Blomen et al. SCIENCE
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- The NSD family of protein methyltransferases in human cancer
- (2015) Theodore Vougiouklakis et al. Epigenomics
- Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
- (2015) Akihiro Fujimoto et al. Nature Communications
- Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression
- (2015) H. Ogiwara et al. Cancer Discovery
- ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors
- (2015) J. Shen et al. Cancer Discovery
- JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells
- (2015) Bo Tang et al. Oncotarget
- RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20
- (2015) Jin Woo Park et al. Scientific Reports
- TET proteins and the control of cytosine demethylation in cancer
- (2015) Laurianne Scourzic et al. Genome Medicine
- HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
- (2015) D. M. Woods et al. Cancer Immunology Research
- Synthesis of lysine methyltransferase inhibitors
- (2015) Chunngai Hui et al. Frontiers in Chemistry
- The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia
- (2015) William N. Pappano et al. PLoS One
- Alterations of immune response of non-small cell lung cancer with Azacytidine
- (2015) John Wrangle et al. Oncotarget
- Loss of ARID1A expression sensitizes cancer cells to PI3K- and AKT-inhibition
- (2015) Eleftherios P. Samartzis et al. Oncotarget
- Platelets are required for enhanced activation of the endothelium and fibrinogen in a mouse thrombosis model of APS
- (2014) V. Proulle et al. BLOOD
- The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
- (2014) Joni Van der Meulen et al. BLOOD
- Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
- (2014) B. Xu et al. BLOOD
- Vulnerabilities of Mutant SWI/SNF Complexes in Cancer
- (2014) Katherine C. Helming et al. CANCER CELL
- Antimetastatic Effects of Blocking PD-1 and the Adenosine A2A Receptor
- (2014) D. Mittal et al. CANCER RESEARCH
- Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα
- (2014) Keisuke Yamamoto et al. CARCINOGENESIS
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
- (2014) Luke A. Gilbert et al. CELL
- 5LBA Results of a first-in-man phase I trial assessing OTX015, an orally available BET-bromodomain (BRD) inhibitor, in advanced hematologic malignancies
- (2014) A. Stathis et al. EUROPEAN JOURNAL OF CANCER
- KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review
- (2014) Young-Won Chin et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor
- (2014) Chia-Han Chu et al. JOURNAL OF MEDICINAL CHEMISTRY
- High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction
- (2014) Shihan He et al. JOURNAL OF MEDICINAL CHEMISTRY
- Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
- (2014) Pragya Srivastava et al. LEUKEMIA RESEARCH
- Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
- (2014) B. G. Wilson et al. MOLECULAR AND CELLULAR BIOLOGY
- EZH2: Not EZHY (Easy) to Deal
- (2014) Gauri Deb et al. MOLECULAR CANCER RESEARCH
- Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma
- (2014) S. K. Knutson et al. MOLECULAR CANCER THERAPEUTICS
- Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
- (2014) Fang Cao et al. MOLECULAR CELL
- Comprehensive molecular profiling of lung adenocarcinoma
- (2014) Eric A. Collisson et al. NATURE
- A vaccine targeting mutant IDH1 induces antitumour immunity
- (2014) Theresa Schumacher et al. NATURE
- Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma
- (2014) Carolyn S Lee et al. NATURE GENETICS
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- (2014) Marco Gerlinger et al. NATURE GENETICS
- ARID1B is a specific vulnerability in ARID1A-mutant cancers
- (2014) Katherine C Helming et al. NATURE MEDICINE
- Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma
- (2014) Rintaro Hashizume et al. NATURE MEDICINE
- SET-ting the stage for DNA repair
- (2014) Deepak K Jha et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
- (2014) François Aymard et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy
- (2014) Wei Liu et al. PLoS One
- Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
- (2014) K. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
- (2014) G. R. Hoffman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A rationale to target the SWI/SNF complex for cancer therapy
- (2014) Anja F. Hohmann et al. TRENDS IN GENETICS
- Histone H3 Mutations in Pediatric Brain Tumors
- (2014) X. Liu et al. Cold Spring Harbor Perspectives in Biology
- Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a
- (2014) Ramzi F. Sweis et al. ACS Medicinal Chemistry Letters
- Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes
- (2014) Wangzhi Li et al. Epigenomics
- A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
- (2014) Chen-Chun Pai et al. Nature Communications
- SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
- (2014) Sophia X. Pfister et al. Cell Reports
- SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
- (2014) Sílvia Carvalho et al. eLife
- Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer
- (2014) K. Odunsi et al. Cancer Immunology Research
- The anticancer effects of HDAC inhibitors require the immune system
- (2014) Alison C West et al. OncoImmunology
- Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas
- (2013) Adam M. Fontebasso et al. ACTA NEUROPATHOLOGICA
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Histone H3.3 Mutations: A Variant Path to Cancer
- (2013) Benjamin T.K. Yuen et al. CANCER CELL
- Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
- (2013) Sebastian Bender et al. CANCER CELL
- SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma
- (2013) Eric Letouzé et al. CANCER CELL
- KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells
- (2013) W. L. Berry et al. CANCER RESEARCH
- A Synthetic Lethality-Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1
- (2013) T. Oike et al. CANCER RESEARCH
- KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors
- (2013) Joshua C. Black et al. CELL
- Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: A Report by MSKCC and the KIRC TCGA Research Network
- (2013) A. A. Hakimi et al. CLINICAL CANCER RESEARCH
- Effects of treatment with histone deacetylase inhibitors in solid tumors: a review based on 30 clinical trials
- (2013) Tianzhu Qiu et al. Future Oncology
- The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
- (2013) K.-M. Chan et al. GENES & DEVELOPMENT
- Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
- (2013) Feng Liu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents
- (2013) H Yang et al. LEUKEMIA
- Decitabine has a biphasic effect on natural killer cell viability, phenotype, and function under proliferative conditions
- (2013) Lisa M. Kopp et al. MOLECULAR IMMUNOLOGY
- Landscape of genomic alterations in cervical carcinomas
- (2013) Akinyemi I. Ojesina et al. NATURE
- Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
- (2013) Woojin Kim et al. Nature Chemical Biology
- Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas
- (2013) Miriam J Smith et al. NATURE GENETICS
- Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
- (2013) Cigall Kadoch et al. NATURE GENETICS
- The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
- (2013) Kelly Coffey et al. NUCLEIC ACIDS RESEARCH
- MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma
- (2013) A R Grayson et al. ONCOGENE
- The Spectrum of SWI/SNF Mutations, Ubiquitous in Human Cancers
- (2013) A. Hunter Shain et al. PLoS One
- Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
- (2013) S. K. Knutson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- (2013) P. W. Lewis et al. SCIENCE
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- MAX Inactivation in Small Cell Lung Cancer Disrupts MYC-SWI/SNF Programs and Is Synthetic Lethal with BRG1
- (2013) O. A. Romero et al. Cancer Discovery
- Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN
- (2013) Lynn Bjerke et al. Cancer Discovery
- Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
- (2013) Alexandre Puissant et al. Cancer Discovery
- Analysis of the levels of lysine-specific demethylase 1 (LSD1) mRNA in human ovarian tumors and the effects of chemical LSD1 inhibitors in ovarian cancer cell lines
- (2013) Sergiy Konovalov et al. Journal of Ovarian Research
- The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
- (2013) Kristian W Pajtler et al. Acta Neuropathologica Communications
- Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases
- (2012) Esther C. Y. Woon et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Mutational analysis ofDNMT3Agene in acute leukemias and common solid cancers
- (2012) Min S. Kim et al. APMIS
- Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing
- (2012) A. Dolnik et al. BLOOD
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- A Landscape of Driver Mutations in Melanoma
- (2012) Eran Hodis et al. CELL
- Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
- (2012) Marcin Imielinski et al. CELL
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- Recurrent inactivating mutations ofARID2in non-small cell lung carcinoma
- (2012) Gilles Manceau et al. INTERNATIONAL JOURNAL OF CANCER
- Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l
- (2012) L Chen et al. LEUKEMIA
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Novel mutations target distinct subgroups of medulloblastoma
- (2012) Giles Robinson et al. NATURE
- Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
- (2012) Jeremy Schwartzentruber et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- New lysine methyltransferase drug targets in cancer
- (2012) Tobias Wagner et al. NATURE BIOTECHNOLOGY
- Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes
- (2012) Matthieu Le Gallo et al. NATURE GENETICS
- The genetic landscape of mutations in Burkitt lymphoma
- (2012) Cassandra Love et al. NATURE GENETICS
- Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma
- (2012) Cécile Guichard et al. NATURE GENETICS
- Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma
- (2012) Mark Sausen et al. NATURE GENETICS
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Epigenetic protein families: a new frontier for drug discovery
- (2012) Cheryl H. Arrowsmith et al. NATURE REVIEWS DRUG DISCOVERY
- TET2andDNMT3AMutations in Human T-Cell Lymphoma
- (2012) Lucile Couronné et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing
- (2012) Marco Gerlinger et al. NEW ENGLAND JOURNAL OF MEDICINE
- Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
- (2012) Li Shen et al. PLoS One
- Over-Expression of LSD1 Promotes Proliferation, Migration and Invasion in Non-Small Cell Lung Cancer
- (2012) Tangfeng Lv et al. PLoS One
- Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer
- (2012) A. H. Shain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Overexpression of lysine specific demethylase 1 predicts worse prognosis in primary hepatocellular carcinoma patients
- (2012) Ze-Kun Zhao WORLD JOURNAL OF GASTROENTEROLOGY
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- SDH mutations in cancer
- (2011) Chiara Bardella et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- Inhibition of Histone Lysine Methylation Enhances Cancer-Testis Antigen Expression in Lung Cancer Cells: Implications for Adoptive Immunotherapy of Cancer
- (2011) M. Rao et al. CANCER RESEARCH
- Genetic Interactions in Cancer Progression and Treatment
- (2011) Alan Ashworth et al. CELL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Romidepsin: a novel histone deacetylase inhibitor for cancer
- (2011) Erin M Bertino et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
- (2011) M Fernanda Amary et al. JOURNAL OF PATHOLOGY
- Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway
- (2011) Veerauo V Konkankit et al. Journal of Translational Medicine
- Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
- (2011) M J Walter et al. LEUKEMIA
- CREBBP mutations in relapsed acute lymphoblastic leukaemia
- (2011) Charles G. Mullighan et al. NATURE
- Inactivating mutations of acetyltransferase genes in B-cell lymphoma
- (2011) Laura Pasqualucci et al. NATURE
- Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
- (2011) Ryan D. Morin et al. NATURE
- Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
- (2011) Ignacio Varela et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- The genomic complexity of primary human prostate cancer
- (2011) Michael F. Berger et al. NATURE
- Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
- (2011) Yaoting Gui et al. NATURE GENETICS
- Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
- (2011) Kai Wang et al. NATURE GENETICS
- Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma
- (2011) Meng Li et al. NATURE GENETICS
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- (2011) Xiao-Jing Yan et al. NATURE GENETICS
- Harnessing synthetic lethal interactions in anticancer drug discovery
- (2011) Denise A. Chan et al. NATURE REVIEWS DRUG DISCOVERY
- The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
- (2011) J A Anderton et al. ONCOGENE
- Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
- (2011) L. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
- (2011) Y. Jiao et al. SCIENCE
- Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer
- (2011) R. A. Juergens et al. Cancer Discovery
- Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
- (2010) D. B. Yap et al. BLOOD
- research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia
- (2010) Daniel Antunes Moreno et al. BRITISH JOURNAL OF HAEMATOLOGY
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
- (2010) Austin T. Thiel et al. CANCER CELL
- Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation
- (2010) Boris G. Wilson et al. CANCER CELL
- Histone Methyltransferase Gene SETD2 Is a Novel Tumor Suppressor Gene in Clear Cell Renal Cell Carcinoma
- (2010) Gerben Duns et al. CANCER RESEARCH
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth
- (2010) T. Milde et al. CLINICAL CANCER RESEARCH
- Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases
- (2010) David C. Bedford et al. Epigenetics
- Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas
- (2010) Jefferson Pessoa Hemerly et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma
- (2010) Heiner Adams et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- PHF6 mutations in adult acute myeloid leukemia
- (2010) P Van Vlierberghe et al. LEUKEMIA
- Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
- (2010) O Kosmider et al. LEUKEMIA
- Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
- (2010) Gillian L. Dalgliesh et al. NATURE
- TRIM24 links a non-canonical histone signature to breast cancer
- (2010) Wen-Wei Tsai et al. NATURE
- The landscape of somatic copy-number alteration across human cancers
- (2010) Rameen Beroukhim et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- ARID1AMutations in Endometriosis-Associated Ovarian Carcinomas
- (2010) Kimberly C. Wiegand et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cancer-associated IDH mutations: biomarker and therapeutic opportunities
- (2010) K E Yen et al. ONCOGENE
- Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining
- (2010) S. Fnu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
- (2010) Siân Jones et al. SCIENCE
- Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
- (2009) Shohei Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
- (2009) O. Abdel-Wahab et al. BLOOD
- The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters
- (2009) W Al Sarakbi et al. BMC CANCER
- Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex
- (2009) X. Wang et al. CANCER RESEARCH
- Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma
- (2009) Shuhei Komatsu et al. CARCINOGENESIS
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Acquired mutations in TET2 are common in myelodysplastic syndromes
- (2009) Saskia M C Langemeijer et al. NATURE GENETICS
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
- (2009) Elaine R. Mardis et al. NEW ENGLAND JOURNAL OF MEDICINE
- IDH1andIDH2Mutations in Gliomas
- (2009) Hai Yan et al. NEW ENGLAND JOURNAL OF MEDICINE
- DNA hypomethylation in cancer cells
- (2009) Melanie Ehrlich Epigenomics
- Analysis of the IDH1 codon 132 mutation in brain tumors
- (2008) Jörg Balss et al. ACTA NEUROPATHOLOGICA
- Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
- (2008) Florian R Fritzsche et al. BMC CANCER
- Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors
- (2008) Markus Heidenblad et al. BMC Medical Genomics
- Histone Deacetylase 8 in Neuroblastoma Tumorigenesis
- (2008) I. Oehme et al. CLINICAL CANCER RESEARCH
- An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1
- (2008) Christin L. Hanigan et al. GASTROENTEROLOGY
- Histone H3K4me3 Binding Is Required for the DNA Repair and Apoptotic Activities of ING1 Tumor Suppressor
- (2008) P.V. Peña et al. JOURNAL OF MOLECULAR BIOLOGY
- Loss of INI1 expression defines a unique subset of pediatric undifferentiated soft tissue sarcomas
- (2008) Portia A Kreiger et al. MODERN PATHOLOGY
- SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus
- (2008) S. K. Kia et al. MOLECULAR AND CELLULAR BIOLOGY
- Small cell undifferentiated variant of hepatoblastoma: Adverse clinical and molecular features similar to rhabdoid tumors
- (2008) Angela D. Trobaugh-Lotrario et al. PEDIATRIC BLOOD & CANCER
- Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast
- (2008) A. Roguev et al. SCIENCE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More