Glutamine and asparagine activate mTORC1 independently of Rag GTPases
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Title
Glutamine and asparagine activate mTORC1 independently of Rag GTPases
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 295, Issue 10, Pages 2890-2899
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2020-02-05
DOI
10.1074/jbc.ac119.011578
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Note: Only part of the references are listed.- As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
- (2018) Natalya N. Pavlova et al. Cell Metabolism
- Asparagine and Glutamine: Co-conspirators Fueling Metastasis
- (2018) Ming Luo et al. Cell Metabolism
- Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane
- (2018) Hirofumi Ukai et al. PLoS Genetics
- An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles
- (2017) Mirai Tanigawa et al. MOLECULAR AND CELLULAR BIOLOGY
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
- (2017) Haijuan Yang et al. NATURE
- Nutrient acquisition strategies of mammalian cells
- (2017) Wilhelm Palm et al. NATURE
- KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
- (2017) Rachel L. Wolfson et al. NATURE
- Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
- (2017) Monther Abu-Remaileh et al. SCIENCE
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
- (2016) Lynne Chantranupong et al. CELL
- Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
- (2016) Robert A. Saxton et al. NATURE
- Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor
- (2016) Abigail S. Krall et al. Nature Communications
- A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways
- (2015) Ana P Gomes et al. CURRENT OPINION IN BIOTECHNOLOGY
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
- (2015) Jennifer Jung et al. MOLECULAR AND CELLULAR BIOLOGY
- A LAPF/phafin1-like protein regulates TORC1 and lysosomal membrane permeabilization in response to endoplasmic reticulum membrane stress
- (2015) Adam Kim et al. MOLECULAR BIOLOGY OF THE CELL
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
- (2015) R. A. Saxton et al. SCIENCE
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Differential regulation of mTORC1 by leucine and glutamine
- (2015) J. L. Jewell et al. SCIENCE
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins
- (2014) Daniele Stracka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
- (2014) Lynne Chantranupong et al. Cell Reports
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Amino acid signalling upstream of mTOR
- (2013) Jenna L. Jewell et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Nutrient signaling to mTOR and cell growth
- (2013) Jenna L. Jewell et al. TRENDS IN BIOCHEMICAL SCIENCES
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
- (2012) Sang Gyun Kim et al. MOLECULAR CELL
- Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
- (2012) Kristan E. van der Vos et al. NATURE CELL BIOLOGY
- Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
- (2011) R. Gong et al. GENES & DEVELOPMENT
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide
- (2010) Caroline Bauchart-Thevret et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
- (2009) Paul Nicklin et al. CELL
- Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment
- (2009) K. Inoki et al. HUMAN MOLECULAR GENETICS
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
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