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Title
mTOR substrate phosphorylation in growth control
Authors
Keywords
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Journal
CELL
Volume 185, Issue 11, Pages 1814-1836
Publisher
Elsevier BV
Online
2022-05-16
DOI
10.1016/j.cell.2022.04.013
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Note: Only part of the references are listed.- Regulation of Autophagy Enzymes by Nutrient Signaling
- (2021) Karyn E. King et al. TRENDS IN BIOCHEMICAL SCIENCES
- mTORC1 induces eukaryotic translation initiation factor 4E interaction with TOS-S6 kinase 1 and its activation
- (2021) Sheikh Tahir Majeed et al. CELL CYCLE
- The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
- (2021) Raphael Böhm et al. MOLECULAR CELL
- mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif
- (2021) Timothy R. Baffi et al. Science Signaling
- Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
- (2021) Josué M. J. Ramirez Reyes et al. Frontiers in Cell and Developmental Biology
- Phosphorylation of Androgen Receptor by mTORC1 Promotes Liver Steatosis and Tumorigenesis
- (2021) Qian‐Nan Ren et al. HEPATOLOGY
- An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
- (2021) Julian Nüchel et al. MOLECULAR CELL
- SAR1B senses leucine levels to regulate mTORC1 signalling
- (2021) Jie Chen et al. NATURE
- Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
- (2021) Linda Truebestein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
- (2021) Maren Heimhalt et al. eLife
- Regulation of human mTOR complexes by DEPTOR
- (2021) Matthias Wälchli et al. eLife
- mTORC2-mediated direct phosphorylation regulates YAP activity promoting glioblastoma growth and invasive characteristics
- (2021) Brent Holmes et al. NEOPLASIA
- Personalized phosphoproteomics identifies functional signaling
- (2021) Elise J. Needham et al. NATURE BIOTECHNOLOGY
- mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation
- (2021) Hong Huang et al. Nature Communications
- Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast
- (2021) Ladislav Dokládal et al. Cell Reports
- Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8
- (2021) Lukas M Langer et al. eLife
- AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control
- (2020) Asier González et al. Cell Metabolism
- Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
- (2020) Jose A. Viscarra et al. Nature Communications
- Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
- (2020) Lukas M Langer et al. eLife
- A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
- (2020) Gennaro Napolitano et al. NATURE
- Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition
- (2020) Jennifer E. Dawson et al. Nature Communications
- AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation
- (2020) Jeanine L. Van Nostrand et al. GENES & DEVELOPMENT
- mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
- (2020) Jian-Jun Jia et al. NUCLEIC ACIDS RESEARCH
- PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
- (2019) Tong Li et al. Protein & Cell
- AMP-activated protein kinase: the current landscape for drug development
- (2019) Gregory R. Steinberg et al. NATURE REVIEWS DRUG DISCOVERY
- Pacer Is a Mediator of mTORC1 and GSK3-TIP60 Signaling in Regulation of Autophagosome Maturation and Lipid Metabolism
- (2019) Xiawei Cheng et al. MOLECULAR CELL
- Disruption of scaffolding function of mLST8 selectively inhibits mTORC2 assembly and function and suppresses mTORC2-dependent tumor growth in vivo
- (2019) Yoonha Hwang et al. CANCER RESEARCH
- Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program
- (2019) Chintan K. Kikani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2
- (2019) Maria Nieves Martinez Marshall et al. MOLECULAR BIOLOGY OF THE CELL
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
- (2019) Dubek Kazyken et al. Science Signaling
- The Emerging Roles of mTORC1 in Macromanaging Autophagy
- (2019) Akpedje S. Dossou et al. Cancers
- Nutrient regulation of mTORC1 at a glance
- (2019) Kendall J. Condon et al. JOURNAL OF CELL SCIENCE
- Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1
- (2019) Asiya Batool et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation
- (2018) Chi Kwan Tsang et al. MOLECULAR CELL
- DEPTOR at the Nexus of Cancer, Metabolism, and Immunity
- (2018) Alexandre Caron et al. PHYSIOLOGICAL REVIEWS
- mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation
- (2018) Joseph G. Moloughney et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RagC phosphorylation autoregulates mTOR complex 1
- (2018) Guang Yang et al. EMBO JOURNAL
- mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux
- (2018) Wei Wan et al. MOLECULAR CELL
- mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
- (2018) Seung Hee Jung et al. ONCOGENE
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- (2017) Wei Wan et al. MOLECULAR CELL
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- (2017) Yuchao Gu et al. MOLECULAR CELL
- SZT2 dictates GATOR control of mTORC1 signalling
- (2017) Min Peng et al. NATURE
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
- (2017) Haijuan Yang et al. NATURE
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- (2017) Rachel L. Wolfson et al. NATURE
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- (2017) Chun-Song Yang et al. PROSTATE
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
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- (2017) Hisashi Tatebe et al. eLife
- LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
- (2017) Sungki Hong et al. eLife
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- (2016) Lynne Chantranupong et al. CELL
- Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy
- (2016) Cindy Puente et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor
- (2016) Vanessa S. Rodrik-Outmezguine et al. NATURE
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- (2016) Robert A. Saxton et al. NATURE
- Phosphatase PP2A is requisite for the function of regulatory T cells
- (2016) Sokratis A Apostolidis et al. NATURE IMMUNOLOGY
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- (2016) Sandra Eltschinger et al. TRENDS IN CELL BIOLOGY
- mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
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- (2016) Domagoj Baretić et al. Nature Communications
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- (2016) Yaqing Chen et al. Oncotarget
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- (2016) Gerta Hoxhaj et al. eLife
- Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway
- (2016) Zhongchao Gai et al. Cell Discovery
- Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling
- (2016) Jing Xia et al. Cell Discovery
- The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase
- (2015) R. U. Onyenwoke et al. BIOCHEMICAL JOURNAL
- mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR
- (2015) Yancun Yin et al. CELL RESEARCH
- mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
- (2015) M. J. Munson et al. EMBO JOURNAL
- The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization
- (2015) Ryo Ando et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2015) Nicholas Artinian et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The S6K protein family in health and disease
- (2015) Mariana R. Tavares et al. LIFE SCIENCES
- Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate
- (2015) Jennifer Jasmin Schwarz et al. MOLECULAR & CELLULAR PROTEOMICS
- Significance of filamin A in mTORC2 function in glioblastoma
- (2015) Naphat Chantaravisoot et al. Molecular Cancer
- Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2
- (2015) Christl Gaubitz et al. MOLECULAR CELL
- mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation
- (2015) Young-Mi Kim et al. MOLECULAR CELL
- The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
- (2015) Jinbo Han et al. NATURE
- mTORC1 directly phosphorylates and activates ERα upon estrogen stimulation
- (2015) A Alayev et al. ONCOGENE
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A
- (2015) Pui-Mun Wong et al. Nature Communications
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
- (2015) Guang Yang et al. Cell Reports
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- (2015) Sebastiano Sciarretta et al. Cell Reports
- Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch
- (2015) Benjamin Rauwel et al. eLife
- Where is mTOR and what is it doing there?
- (2014) Charles Betz et al. JOURNAL OF CELL BIOLOGY
- Eukaryotic Elongation Factor 2 Kinase Activity Is Controlled by Multiple Inputs from Oncogenic Signaling
- (2014) X. Wang et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2014) N. Raman et al. MOLECULAR AND CELLULAR BIOLOGY
- Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
- (2014) Alaji Bah et al. NATURE
- Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
- (2014) Pengda Liu et al. NATURE
- mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
- (2014) K M Dodd et al. ONCOGENE
- PIP4k is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation
- (2014) A. M. Mackey et al. Science Signaling
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
- (2014) J. A. Martina et al. Science Signaling
- mTOR and autophagy: A dynamic relationship governed by nutrients and energy
- (2014) E.A. Dunlop et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Genesis of Tyrosine Phosphorylation
- (2014) T. Hunter Cold Spring Harbor Perspectives in Biology
- Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy
- (2013) Hai-Xin Yuan et al. Autophagy
- mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
- (2013) Xin Li et al. EMBO REPORTS
- mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts
- (2013) N. Dai et al. GENES & DEVELOPMENT
- Mammalian Target of Rapamycin (mTor) Mediates Tau Protein Dyshomeostasis
- (2013) Zhi Tang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mammalian Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Stabilizes ISCU Protein
- (2013) Ping La et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
- (2013) Constance S. Petit et al. JOURNAL OF CELL BIOLOGY
- Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
- (2013) Jose A. Martina et al. JOURNAL OF CELL BIOLOGY
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
- (2013) Yoshinobu Ichimura et al. MOLECULAR CELL
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
- (2013) Carmine Settembre et al. NATURE CELL BIOLOGY
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- (2013) Pengda Liu et al. NATURE CELL BIOLOGY
- mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
- (2013) Francesca Nazio et al. NATURE CELL BIOLOGY
- Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
- (2013) Christian C. Dibble et al. NATURE CELL BIOLOGY
- Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals
- (2013) S. Sengupta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
- (2012) Jose A. Martina et al. Autophagy
- A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
- (2012) Carmine Settembre et al. EMBO JOURNAL
- mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
- (2012) Sung Jin Kim et al. MOLECULAR CELL
- Glutaminolysis Activates Rag-mTORC1 Signaling
- (2012) Raúl V. Durán et al. MOLECULAR CELL
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
- (2012) Xiaoqing Gan et al. NATURE CELL BIOLOGY
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- (2012) Shiuh-Dih Chou et al. PLoS One
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
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- (2011) Elaine A. Dunlop et al. Autophagy
- Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
- (2011) Brian Magnuson et al. BIOCHEMICAL JOURNAL
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- (2011) Vittoria Zinzalla et al. CELL
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- (2011) Timothy R. Peterson et al. CELL
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- (2011) Bing Su et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
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- (2011) N. Dai et al. GENES & DEVELOPMENT
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- (2011) Jung Ho Back et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
- (2011) Malik M. Keshwani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR Generates an Auto-Amplification Loop by Triggering the βTrCP- and CK1α-Dependent Degradation of DEPTOR
- (2011) Shanshan Duan et al. MOLECULAR CELL
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- (2011) Daming Gao et al. MOLECULAR CELL
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Rapamycin passes the torch: a new generation of mTOR inhibitors
- (2011) Don Benjamin et al. NATURE REVIEWS DRUG DISCOVERY
- Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
- (2011) L. Shang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
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- (2011) P. P. Hsu et al. SCIENCE
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- (2011) C. Settembre et al. SCIENCE
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- (2010) Zhihua Tao et al. BIOCHEMISTRY
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- (2010) Yasemin Sancak et al. CELL
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- (2010) Itay Koren et al. CURRENT BIOLOGY
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- (2010) Won Jun Oh et al. EMBO JOURNAL
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- (2010) A. A. Michels et al. MOLECULAR AND CELLULAR BIOLOGY
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- (2010) Lijun Yan et al. MOLECULAR CELL
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- (2009) Thomas W. Sturgill et al. ACS Chemical Biology
- TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
- (2009) J. Copp et al. CANCER RESEARCH
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- Raptor Binds the SAIN (Shc and IRS-1 NPXY Binding) Domain of Insulin Receptor Substrate-1 (IRS-1) and Regulates the Phosphorylation of IRS-1 at Ser-636/639 by mTOR
- (2009) Alexandros Tzatsos JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Lifu Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
- (2009) Ghada A. Soliman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser863and Multisite Phosphorylation
- (2009) Kathryn G. Foster et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
- (2009) C. C. Dibble et al. MOLECULAR AND CELLULAR BIOLOGY
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain
- (2009) Doris Berchtold et al. MOLECULAR BIOLOGY OF THE CELL
- Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
- (2009) Véronique Calleja et al. PLOS BIOLOGY
- The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
- (2008) Jingxiang Huang et al. BIOCHEMICAL JOURNAL
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- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
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- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
- The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
- (2008) Valeria Facchinetti et al. EMBO JOURNAL
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- (2008) Wei Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2008) Lifu Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2008) Dana M. Gwinn et al. MOLECULAR CELL
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- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
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- (2008) Y. Sancak et al. SCIENCE
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