Vascular dementia: A microglia's perspective

Necrotizing enterocolitis induces T lymphocyte–mediated injury in the developing mammalian brain

(2021) Qinjie Zhou et al.   Science Translational Medicine

Significant higher‐level C‐C motif chemokine ligand 2/3 and chemotactic power in cerebral white matter than grey matter in rat and human

(2021) Jingdong Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis

(2021) Yaling Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion

(2021) Kaoru Suzuki et al.   Journal of Neuroinflammation

Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion

(2021) Sai Sampath Thammisetty et al.   Neurotherapeutics

Adalimumab ameliorates memory impairments and neuroinflammation in chronic cerebral hypoperfusion rats

(2021) Jing-Jing Xu et al.   Aging-US

Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

(2021) Qian Liu et al.   Journal of Neuroinflammation

NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

(2021) Yao Zhao et al.   Journal of Neuroinflammation

Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion

(2021) Xinnan Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Bisindole compound 4ae ameliorated cognitive impairment in rats with vascular dementia by anti-inflammation effect via microglia cells

(2021) Feng Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

(2020) Jiawei Zhang et al.   Journal of Neuroinflammation

Microglial activation and responses to vasculature that result from an acute LPS exposure

(2020) John F. Bowyer et al.   NEUROTOXICOLOGY

AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice

(2020) Hyunha Kim et al.   BRAIN BEHAVIOR AND IMMUNITY

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis

(2020) Francesca Cignarella et al.   ACTA NEUROPATHOLOGICA

Loss of Capillary Pericytes and the Blood‐Brain Barrier in White Matter in Post‐Stroke and Vascular Dementias and Alzheimer’s Disease

(2020) Ren Ding et al.   BRAIN PATHOLOGY

Chronic cerebral hypoperfusion activates AIM2 and NLRP3 inflammasome

(2020) Hirofumi Matsuyama et al.   BRAIN RESEARCH

Microglia phagocytose myelin sheaths to modify developmental myelination

(2020) Alexandria N. Hughes et al.   NATURE NEUROSCIENCE

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity

(2020) João Paulo Brás et al.   Cell Death & Disease

TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia

(2020) Qian Wang et al.   NEURAL PLASTICITY

Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition via Inhibition NLRP3 Inflammasome

(2020) Yiwei Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model

(2020) Min Kyung Song et al.   BRAIN RESEARCH BULLETIN

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

(2020) Meng Mao et al.   Journal of Neuroinflammation

Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain

(2020) Lei Zhao et al.   Nature Communications

Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment

(2020) Emma Sigfridsson et al.   Journal of Neuroinflammation

Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions

(2020) Yu Du et al.   MEDIATORS OF INFLAMMATION

Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study

(2020) Longfei Jia et al.   Lancet Public Health

White matter lesions, cerebral inflammation and cognitive function in a mouse model of cerebral hypoperfusion

(2019) Hagar Ben-Ari et al.   BRAIN RESEARCH

Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice

(2019) Rong Zhao et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Aβ1-40-injected mouse model of Alzheimer's disease

(2019) JIAE Park et al.   CYTOTHERAPY

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Epidemiology of Vascular Dementia

(2019) Frank J. Wolters et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparative benefits of simvastatin and exercise in a mouse model of vascular cognitive impairment and dementia

(2019) Lianne J. Trigiani et al.   FASEB JOURNAL

Resveratrol Activates Autophagy via the AKT/mTOR Signaling Pathway to Improve Cognitive Dysfunction in Rats With Chronic Cerebral Hypoperfusion

(2019) Nan Wang et al.   Frontiers in Neuroscience

Polyethylene glycol-conjugated human adrenomedullin as a possible treatment for vascular dementia

(2019) Sayaka Nagata et al.   PEPTIDES

mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

(2019) Yaling Hu et al.   GLIA

Ferulic acid attenuates oxidative DNA damage and inflammatory responses in microglia induced by benzo(a)pyrene

(2019) Yongfen Bao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate

(2019) Kazuo Washida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice

(2019) Ying Yu et al.   JOURNAL OF NEUROCHEMISTRY

Altered microglia and neurovasculature in the Alzheimer's disease cerebellum

(2019) Malvindar K. Singh-Bains et al.   NEUROBIOLOGY OF DISEASE

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways

(2018) Junichi Matsumoto et al.   BRAIN RESEARCH

Postoperative intermittent fasting prevents hippocampal oxidative stress and memory deficits in a rat model of chronic cerebral hypoperfusion

(2018) Yuan Hu et al.   EUROPEAN JOURNAL OF NUTRITION

White matter degeneration in vascular and other ageing-related dementias

(2018) Yoshiki Hase et al.   JOURNAL OF NEUROCHEMISTRY

Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

(2018) Guillermo Carbajosa et al.   NEUROBIOLOGY OF AGING

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury

(2018) Yi Yang et al.   NEUROBIOLOGY OF DISEASE

Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells

(2018) Brahim Gargouri et al.   PHYTOMEDICINE

Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice

(2018) Jill M. Roberts et al.   PLoS One

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2

(2018) Xian-Qin Luo et al.   Chinese Medicine

Increased BBB Permeability Enhances Activation of Microglia and Exacerbates Loss of Dendritic Spines After Transient Global Cerebral Ischemia

(2018) Furong Ju et al.   Frontiers in Cellular Neuroscience

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

(2018) Gene L. Bowman et al.   Alzheimers & Dementia

Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions

(2018) Karin M. E. Forsberg et al.   Acta Neuropathologica Communications

Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

(2017) Jae-Hong Kim et al.   GLIA

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

(2017) Jordan B Jahrling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

(2017) Jill H Fowler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Staining of HLA-DR, Iba1 and CD68 in human microglia reveals partially overlapping expression depending on cellular morphology and pathology

(2017) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROIMMUNOLOGY

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

(2017) Yoshiki Hase et al.   Journal of Neuroinflammation

Markers of microglia in post-mortem brain samples from patients with Alzheimer’s disease: a systematic review

(2017) K E Hopperton et al.   MOLECULAR PSYCHIATRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

(2017) Kassandra Kisler et al.   NATURE REVIEWS NEUROSCIENCE

CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients

(2017) Tobias Skillbäck et al.   NEUROBIOLOGY OF AGING

Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

(2017) Tiffany L. Sudduth et al.   NEUROSCIENCE

The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats

(2017) Jae-Min Lee et al.   NEUROSCIENCE LETTERS

Neuropathology of White Matter Lesions, Blood–Brain Barrier Dysfunction, and Dementia

(2017) Atticus H. Hainsworth et al.   STROKE

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia

(2017) Rosalba Siracusa et al.   Frontiers in Neurology

Selective Modulator of Cannabinoid Receptor Type 2 Reduces Memory Impairment and Infarct Size During Cerebral Hypoperfusion and Vascular Dementia

(2016) Shalini Jayant et al.   CURRENT NEUROVASCULAR RESEARCH

Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway

(2016) Li Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

(2016) Rika Sakuma et al.   Journal of Neuroinflammation

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

(2016) Nanhong Lou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signaling

(2015) Ki Mo Lee et al.   BMC Complementary and Alternative Medicine

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

(2015) Aiqing Chen et al.   BRAIN

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Models and mechanisms of vascular dementia

(2015) Poornima Venkat et al.   EXPERIMENTAL NEUROLOGY

The neuropathology and cerebrovascular mechanisms of dementia

(2015) Limor Raz et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cathepsin L Acutely Alters Microvessel Integrity within the Neurovascular Unit during Focal Cerebral Ischemia

(2015) Yu-Huan Gu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Vascular dementia

(2015) John T O'Brien et al.   LANCET

Neuroprotective Effects of Electroacupuncture on an Animal Model of Bilateral Common Carotid Artery Occlusion

(2015) Eun Jin Yang et al.   MOLECULAR NEUROBIOLOGY

Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion

(2015) Jing Ma et al.   Scientific Reports

T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment

(2015) Li Chen et al.   Scientific Reports

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

(2014) E.R. Detrait et al.   NEUROCHEMISTRY INTERNATIONAL

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

(2014) Junichi Matsumoto et al.   NEUROSCIENCE LETTERS

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

The Role of Microglia and Matrix Metalloproteinases Involvement in Neuroinflammation and Gliomas

(2013) Helen Könnecke et al.   Clinical & Developmental Immunology

Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation

(2013) Zoran B. Redzic et al.   International Journal of Stroke

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

(2013) Starlee Lively et al.   Journal of Neuroinflammation

Microglia are the major source of TNF-α and TGF-β1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin

(2013) Jennifer V. Welser-Alves et al.   NEUROCHEMISTRY INTERNATIONAL

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia

(2013) Dongyu Min et al.   NEUROSCIENCE LETTERS

Activated microglia enhance neurogenesis via trypsinogen secretion

(2013) A. M. Nikolakopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of TGF-β in Survival of Phagocytizing Microglia: Autocrine Suppression of TNF-α Production and Oxidative Stress

(2013) Keun-Young Ryu et al.   Experimental Neurobiology

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

(2012) Jing Ma et al.   CNS Neuroscience & Therapeutics

Tong Luo Jiu Nao injection, a traditional Chinese medicinal preparation, inhibits MIP-1β expression in brain microvascular endothelial cells injured by oxygen-glucose deprivation

(2012) Jun Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Polydatin protects learning and memory impairments in a rat model of vascular dementia

(2012) Run-Ping Li et al.   PHYTOMEDICINE

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Impact of paracrine signals from brain microvascular endothelial cells on microglial proliferation and migration

(2011) Jun Wang et al.   BRAIN RESEARCH BULLETIN

Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide

(2011) Andrej Kovac et al.   Journal of Neuroinflammation

Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies

(2010) Masafumi Ihara et al.   ACTA NEUROPATHOLOGICA

Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression

(2010) Mariko Noda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Experimental models of vascular dementia and vascular cognitive impairment: a systematic review

(2010) Nadim S. Jiwa et al.   JOURNAL OF NEUROCHEMISTRY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia

(2010) Gustavo C. Román et al.   STROKE

Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition

(2009) Dashdemberel Narantuya et al.   BRAIN RESEARCH

Anandamide enhances IL-10 production in activated microglia by targeting CB2receptors: Roles of ERK1/2, JNK, and NF-κB

(2009) Fernando Correa et al.   GLIA

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Involvement of heparanase in migration of microglial cells

(2008) Hisaaki Takahashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice

(2008) Tsuyoshi Nishioku et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Prevalence of Dementia and Its Subtypes in an Elderly Urban Korean Population: Results from the Korean Longitudinal Study on Health and Aging (KLoSHA)

(2008) Jin Hyeong Jhoo et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion

(2008) Zhi-You Cai et al.   Neuroscience Bulletin

Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

(2007) Kaichi Yoshizaki et al.   EXPERIMENTAL NEUROLOGY