mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

(2019) Syam Nair et al.   GLIA

Role of the P2X7 receptor in inflammation-mediated changes in the osteogenesis of periodontal ligament stem cells

(2019) Xin-Yue Xu et al.   Cell Death & Disease

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

(2019) Li-Jun Zhou et al.   Cell Reports

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K + Channel THIK-1

(2018) Christian Madry et al.   NEURON

Noninflammatory Changes of Microglia Are Sufficient to Cause Epilepsy

(2018) Xiaofeng Zhao et al.   Cell Reports

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

(2018) Dale B. Bosco et al.   Molecular Brain

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

(2018) Feilong Wang et al.   Cell Metabolism

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

Carbon monoxide reverses the metabolic adaptation of microglia cells to an inflammatory stimulus

(2017) Jayne Louise Wilson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

(2017) Na Yue et al.   Journal of Neuroinflammation

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

(2017) Yiguo Shen et al.   Nature Communications

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

(2016) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

mTORC1 pathway disruption ameliorates brain inflammation following stroke via a shift in microglia phenotype from M1 type to M2 type

(2016) Daojing Li et al.   FASEB JOURNAL

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

A Novel Size-Based Sorting Mechanism of Pinocytic Luminal Cargoes in Microglia

(2015) C. Chen et al.   JOURNAL OF NEUROSCIENCE

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

(2015) Shu-Feng Zhou et al.   Drug Design Development and Therapy

PP2AC Level Determines Differential Programming of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer

(2015) Yanjie Zhang et al.   EBioMedicine

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

Protein kinase C and P2Y12take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets

(2014) S. F. Moore et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Analysis of microglial migration by a micropipette assay

(2014) Hang-jun Wu et al.   Nature Protocols

TSC1 controls macrophage polarization to prevent inflammatory disease

(2014) Linnan Zhu et al.   Nature Communications

Toll-Like Receptors 2, -3 and -4 Prime Microglia but not Astrocytes Across Central Nervous System Regions for ATP-Dependent Interleukin-1β Release

(2014) Laura Facci et al.   Scientific Reports

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

P2Y4 Receptor-Mediated Pinocytosis Contributes to Amyloid Beta-Induced Self-Uptake by Microglia

(2013) H.-q. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia

(2013) Robert W. Freilich et al.   PLoS One

Polarization of macrophages and microglia in inflammatory demyelination

(2013) Li Cao et al.   Neuroscience Bulletin

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

NTPDase1 activity attenuates microglial phagocytosis

(2012) Larisa Bulavina et al.   Purinergic Signalling

The P2X7 receptor is a key modulator of aerobic glycolysis

(2012) F Amoroso et al.   Cell Death & Disease

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

S100B Protein Stimulates Microglia Migration via RAGE-dependent Up-regulation of Chemokine Expression and Release

(2011) Roberta Bianchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease

(2011) Jia Yao et al.   PLoS One

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

P2X4-Receptor-Mediated Synthesis and Release of Brain-Derived Neurotrophic Factor in Microglia Is Dependent on Calcium and p38-Mitogen-Activated Protein Kinase Activation

(2009) T. Trang et al.   JOURNAL OF NEUROSCIENCE

Lysophosphatidic acid receptor activation affects the C13NJ microglia cell line proteome leading to alterations in glycolysis, motility, and cytoskeletal architecture

(2009) Eva Bernhart et al.   PROTEOMICS