NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus

(2020) Jiawei Zhang et al.   Journal of Neuroinflammation

Mitochondrial DNA in inflammation and immunity

(2020) Joel S Riley et al.   EMBO REPORTS

Role of Silent Information Regulator 1 (SIRT1) in Regulating Oxidative Stress and Inflammation

(2020) Vivek Singh et al.   INFLAMMATION

Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation

(2020) Martina Chiurazzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration

(2020) Kai Kaarniranta et al.   PROGRESS IN RETINAL AND EYE RESEARCH

NAD+ administration decreases microvascular damage following cardiac ischemia/reperfusion by restoring autophagic flux

(2020) You-Jun Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

(2020) Matthew R. Lynch et al.   JCI Insight

ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease

(2020) Dominic S. A. Simpson et al.   Antioxidants

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

(2020) Bo Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial Dysfunction and Alzheimer’s Disease: Role of Microglia

(2020) Ishan Agrawal et al.   Frontiers in Aging Neuroscience

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Glycyrrhizic acid renders robust neuroprotection in rodent model of vascular dementia by controlling oxidative stress and curtailing cytochrome-c release

(2019) Yogeshkanna Sathyamoorthy et al.   NUTRITIONAL NEUROSCIENCE

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Mitophagy and NAD+ inhibit Alzheimer disease

(2019) Evandro F. Fang   Autophagy

Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics

(2019) Annadurai Thangaraj et al.   Autophagy

Mitochondria at the interface between neurodegeneration and neuroinflammation

(2019) Verian Bader et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

NAD+ homeostasis in renal health and disease

(2019) Kenneth M. Ralto et al.   Nature Reviews Nephrology

Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

(2019) Sofie Lautrup et al.   NEUROCHEMISTRY INTERNATIONAL

NAD+ precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms

(2019) Nina Klimova et al.   EXPERIMENTAL NEUROLOGY

Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate

(2019) Kazuo Washida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion

(2019) Shao-Hua Su et al.   Journal of Neuroinflammation

Applications of the Morris water maze in translational traumatic brain injury research

(2018) Laura B. Tucker et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Regulation of diabetic cardiomyopathy by caloric restriction is mediated by intracellular signaling pathways involving ‘SIRT1 and PGC-1α’

(2018) Maayan Waldman et al.   Cardiovascular Diabetology

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

(2018) Ting Yuan et al.   Redox Biology

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

(2017) Yoshiki Hase et al.   Journal of Neuroinflammation

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Priming of the neutrophil respiratory burst: role in host defense and inflammation

(2016) Jamel El-Benna et al.   IMMUNOLOGICAL REVIEWS

Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

(2016) Si-Qi Du et al.   MOLECULAR NEUROBIOLOGY

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

High‐Fat‐Diet Intake Enhances Cerebral Amyloid Angiopathy and Cognitive Impairment in a Mouse Model of Alzheimer's Disease, Independently of Metabolic Disorders

(2016) Bowen Lin et al.   Journal of the American Heart Association

Mitochondrial quality control: Easy come, easy go

(2015) Aleksandr Stotland et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Models and mechanisms of vascular dementia

(2015) Poornima Venkat et al.   EXPERIMENTAL NEUROLOGY

Vascular dementia

(2015) John T O'Brien et al.   LANCET

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

(2014) Evandro Fei Fang et al.   CELL

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gene Ontology based housekeeping gene selection for RNA-seq normalization

(2014) Chien-Ming Chen et al.   METHODS

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

(2013) Bing Gong et al.   NEUROBIOLOGY OF AGING

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Laser speckle contrast imaging in biomedical optics

(2010) David A. Boas et al.   JOURNAL OF BIOMEDICAL OPTICS

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

NOX Enzymes and Pulmonary Disease

(2009) Brian Griffith et al.   ANTIOXIDANTS & REDOX SIGNALING

Review of laser speckle contrast techniques for visualizing tissue perfusion

(2008) Matthijs Draijer et al.   LASERS IN MEDICAL SCIENCE