White matter degeneration in vascular and other ageing-related dementias

Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

(2017) Yasmina Manso et al.   GLIA

An endothelial link between the benefits of physical exercise in dementia

(2017) Lianne J Trigiani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differing associations between Aβ accumulation, hypoperfusion, blood–brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease

(2017) J Scott Miners et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion

(2017) Yoshiki Hase et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ageing causes prominent neurovascular dysfunction associated with loss of astrocytic contacts and gliosis

(2017) J. Duncombe et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Age-associated changes in the blood-brain barrier: comparative studies in human and mouse

(2017) E. F. Goodall et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neuropathology of White Matter Lesions, Blood–Brain Barrier Dysfunction, and Dementia

(2017) Atticus H. Hainsworth et al.   STROKE

Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation

(2017) Gilly Wolf et al.   Frontiers in Aging Neuroscience

Long-term cilostazol treatment reduces gliovascular damage and memory impairment in a mouse model of chronic cerebral hypoperfusion

(2017) Akihiro Kitamura et al.   Scientific Reports

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease

(2016) Raj N. Kalaria   ACTA NEUROPATHOLOGICA

Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment

(2016) Olivia A. Skrobot et al.   BRAIN

Disruption of White Matter Integrity by Chronic Cerebral Hypoperfusion in Alzheimer’s Disease Mouse Model

(2016) Yun Zhai et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral blood flow in small vessel disease: A systematic review and meta-analysis

(2016) Yulu Shi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

White Matter Diffusion Abnormalities in Carotid Artery Disease: A Systematic Review and Meta-Analysis

(2016) Hediyeh Baradaran et al.   JOURNAL OF NEUROIMAGING

Reactive astrocytes and therapeutic potential in focal ischemic stroke

(2016) Gourav Roy Choudhury et al.   NEUROBIOLOGY OF DISEASE

Microinfarcts in an older population-representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease

(2016) P. G. Ince et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

White Matter Hyperintensities Are Under Strong Genetic Influence

(2016) Perminder S. Sachdev et al.   STROKE

Substantial Reduction of Parenchymal Cerebral Blood Flow in Mice with Bilateral Common Carotid Artery Stenosis

(2016) Yorito Hattori et al.   Scientific Reports

Gradual Carotid Artery Stenosis in Mice Closely Replicates Hypoperfusive Vascular Dementia in Humans

(2016) Yorito Hattori et al.   Journal of the American Heart Association

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia

(2015) Aiqing Chen et al.   BRAIN

Molecular disorganization of axons adjacent to human lacunar infarcts

(2015) Jason D. Hinman et al.   BRAIN

Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease

(2015) Philip R Holland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

(2015) N. Miyamoto et al.   JOURNAL OF NEUROSCIENCE

White matter hyperintensities, cognitive impairment and dementia: an update

(2015) Niels D. Prins et al.   Nature Reviews Neurology

Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter

(2015) Takakuni Maki et al.   NEUROSCIENCE LETTERS

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

(2015) Takakuni Maki et al.   Stem Cell Research

Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion

(2015) Jing Ma et al.   Scientific Reports

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Pyramidal neurons of the prefrontal cortex in post-stroke, vascular and other ageing-related dementias

(2014) Vincent Foster et al.   BRAIN

Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia

(2014) Rachel Barker et al.   BRAIN

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

(2014) Sufana Al-Mashhadi et al.   BRAIN PATHOLOGY

Microglial Activation with Reduction in Autophagy Limits White Matter Lesions and Improves Cognitive Defects During Cerebral Hypoperfusion

(2014) Zhao Yang et al.   CURRENT NEUROVASCULAR RESEARCH

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

(2014) M. Duering et al.   NEUROLOGY

From precursors to myelinating oligodendrocytes: Contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

(2014) J.J. Boulanger et al.   NEUROSCIENCE

A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood–brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion

(2014) Nobukazu Miyamoto et al.   NEUROSCIENCE LETTERS

Longitudinal Grey and White Matter Changes in Frontotemporal Dementia and Alzheimer’s Disease

(2014) Lars Frings et al.   PLoS One

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

(2014) Yumiko Mitome-Mishima et al.   Biomed Research International

Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease

(2014) Philip Benjamin et al.   NeuroImage-Clinical

Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre

(2013) Jon B. Toledo et al.   BRAIN

Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease

(2013) M. Duering et al.   BRAIN

Quantitative Vascular Pathology and Phenotyping Familial and Sporadic Cerebral Small Vessel Diseases

(2013) Lucinda J. L. Craggs et al.   BRAIN PATHOLOGY

Assessing White Matter Ischemic Damage in Dementia Patients by Measurement of Myelin Proteins

(2013) Rachel Barker et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cognitive impairment after lacunar stroke: systematic review and meta-analysis of incidence, prevalence and comparison with other stroke subtypes

(2013) S. D. J. Makin et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Brain white matter oedema due to ClC-2 chloride channel deficiency: an observational analytical study

(2013) Christel Depienne et al.   LANCET NEUROLOGY

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Vascular and neurodegenerative pathways—will they meet?

(2013) Raj N. Kalaria et al.   Nature Reviews Neurology

White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)

(2013) Lucinda J. L. Craggs et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds

(2013) B. M. Janaway et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation

(2013) Adrian Nahirnyj et al.   PLoS One

Oxidative Stress Interferes With White Matter Renewal After Prolonged Cerebral Hypoperfusion in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

Age-Related Decline in Oligodendrogenesis Retards White Matter Repair in Mice

(2013) Nobukazu Miyamoto et al.   STROKE

17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status

(2013) Poneh Adib-Samii et al.   STROKE

The association between cognitive function and white matter lesion location in older adults: a systematic review

(2012) Niousha Bolandzadeh et al.   BMC Neurology

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-α secretion after subacute cerebral ischemia

(2012) JIANPING WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Carotid Stenosis: A Risk Factor for Cerebral White-matter Disease

(2012) Nagaendran Kandiah et al.   Journal of Stroke & Cerebrovascular Diseases

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Incident subcortical infarcts induce focal thinning in connected cortical regions

(2012) M. Duering et al.   NEUROLOGY

Staging and natural history of cerebrovascular pathology in dementia

(2012) V. Deramecourt et al.   NEUROLOGY

Atheromatous disease in small intracerebral vessels, microinfarcts and dementia

(2012) R. N. Kalaria et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Magnetic resonance imaging of fixedpost mortembrains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter

(2012) K. E. McAleese et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Axon pathology in age-related neurodegenerative disorders

(2012) R. Adalbert et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Blood–Brain Barrier Permeability and Long-Term Clinical and Imaging Outcomes in Cerebral Small Vessel Disease

(2012) Joanna M. Wardlaw et al.   STROKE

Genome-wide association studies of cerebral white matter lesion burden

(2011) Myriam Fornage et al.   ANNALS OF NEUROLOGY

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL

(2011) Marco Duering et al.   BRAIN

Astrocytes and pericytes cooperatively maintain a capillary-like structure composed of endothelial cells on gel matrix

(2011) Yoshiaki Itoh et al.   BRAIN RESEARCH

2001–2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease?

(2011)   CEREBROVASCULAR DISEASES

Attenuation of Brain Damage and Cognitive Impairment by Direct Renin Inhibition in Mice With Chronic Cerebral Hypoperfusion

(2011) Yi-Fei Dong et al.   HYPERTENSION

Different Associations of Periventricular and Deep White Matter Lesions with Cognition, Neuropsychiatric Symptoms, and Daily Activities in Dementia

(2011) Kee Hyung Park et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Rapid Disruption of Axon-Glial Integrity in Response to Mild Cerebral Hypoperfusion

(2011) M. M. Reimer et al.   JOURNAL OF NEUROSCIENCE

Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: A 3-year follow-up of the LADIS study cohort

(2011) C. Ryberg et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Incident lacunes influence cognitive decline: The LADIS study

(2011) H. Jokinen et al.   NEUROLOGY

Cerebral blood flow by arterial spin labeling in poststroke dementia

(2011) M. J. Firbank et al.   NEUROLOGY

Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction

(2011) Takakuni Maki et al.   NEUROREPORT

Angiogenic and Vasoprotective Effects of Adrenomedullin on Prevention of Cognitive Decline After Chronic Cerebral Hypoperfusion in Mice

(2011) Takakuni Maki et al.   STROKE

Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies

(2010) Masafumi Ihara et al.   ACTA NEUROPATHOLOGICA

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Mechanisms and functions of p38 MAPK signalling

(2010) Ana Cuadrado et al.   BIOCHEMICAL JOURNAL

Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

(2010) A. A. Gouw et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

(2010) Leonardo Pantoni   LANCET NEUROLOGY

Absence of cortical demyelination in neuromyelitis optica

(2010) B. F. G. Popescu et al.   NEUROLOGY

Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain

(2010) Julie E. Simpson et al.   NEUROSCIENCE LETTERS

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Nonhypotensive Dose of Telmisartan Attenuates Cognitive Impairment Partially Due to Peroxisome Proliferator-Activated Receptor-γ Activation in Mice With Chronic Cerebral Hypoperfusion

(2010) Kazuo Washida et al.   STROKE

A Mouse Model Characterizing Features of Vascular Dementia With Hippocampal Atrophy

(2010) Keiko Nishio et al.   STROKE

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

White Matter Lesions and Brain Atrophy: More than Shared Risk Factors? A Systematic Review

(2009) Auke P.A. Appelman et al.   CEREBROVASCULAR DISEASES

Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain

(2009) Toru Yamashita et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Microvascular changes in the white mater in dementia

(2009) William R. Brown et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

(2009) Hongxia Shen et al.   NEUROBIOLOGY OF DISEASE

Water transport between CNS compartments: functional and molecular interactions between aquaporins and ion channels

(2009) V. Benfenati et al.   NEUROSCIENCE

Epidemiological Pathology of Dementia: Attributable-Risks at Death in the Medical Research Council Cognitive Function and Ageing Study

(2009) Fiona E. Matthews et al.   PLOS MEDICINE

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology

(2008) A. A. Gouw et al.   BRAIN

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

(2008) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period

(2008) Alida A. Gouw et al.   STROKE

Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways

(2008) Julie E. Simpson et al.   STROKE