Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

(2016) Axel Montagne et al.   ACTA NEUROPATHOLOGICA

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

(2016) Amy R. Nelson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Differential Effects of APOE Genotypes on the Anterior and Posterior Subnetworks of Default Mode Network in Amnestic Mild Cognitive Impairment

(2016) Baoyu Yuan et al.   JOURNAL OF ALZHEIMERS DISEASE

Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients

(2016) Miranka Wirth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pericytes as Inducers of Rapid, Matrix Metalloproteinase-9-Dependent Capillary Damage during Ischemia

(2016) Robert G. Underly et al.   JOURNAL OF NEUROSCIENCE

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

(2016) Kyle R. Biesecker et al.   JOURNAL OF NEUROSCIENCE

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation

(2016) Helen Shinru Wei et al.   NEURON

Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide

(2016) Noboru Toda et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Cell type specificity of neurovascular coupling in cerebral cortex

(2016) Hana Uhlirova et al.   eLife

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

(2016) Maximilian Wiesmann et al.   NEURAL PLASTICITY

Reduced cerebrovascular reactivity in young adults carrying the APOE ε4 allele

(2015) Sana Suri et al.   Alzheimers & Dementia

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

(2015) Heather M. Snyder et al.   Alzheimers & Dementia

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Purinergic transmission in blood vessels

(2015) Vera Ralevic et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Arterial spin labeling imaging reveals widespread and Aβ-independent reductions in cerebral blood flow in elderly apolipoprotein epsilon-4 carriers

(2015) Lars Michels et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Diverse Functions of Pericytes in Cerebral Blood Flow Regulation and Ischemia

(2015) Francisco Fernandez-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrospinal Fluid Biomarkers of Neurovascular Dysfunction in Mild Dementia and Alzheimer'S Disease

(2015) Melanie D Sweeney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocyte Contributions to Flow/Pressure-Evoked Parenchymal Arteriole Vasoconstriction

(2015) K. J. Kim et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Carbon Dioxide Vasoreactivity, and Cognition in Older Adults: Effect of Hypertension

(2015) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Vascular Inward Rectifier K+Channels as External K+Sensors in the Control of Cerebral Blood Flow

(2015) Thomas A. Longden et al.   MICROCIRCULATION

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Neuroglial Transmission

(2015) Vidar Gundersen et al.   PHYSIOLOGICAL REVIEWS

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Stroke and Potentially Preventable Dementias Proclamation

(2015) Vladimir Hachinski   STROKE

Astrocyte Regulation of Blood Flow in the Brain

(2015) Brian A. MacVicar et al.   Cold Spring Harbor Perspectives in Biology

Pericyte structure and distribution in the cerebral cortex revealed by high-resolution imaging of transgenic mice

(2015) David A. Hartmann et al.   Neurophotonics

Coupling Mechanism and Significance of the BOLD Signal: A Status Report

(2014) Elizabeth M.C. Hillman   Annual Review of Neuroscience

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

Impaired Cerebral Autoregulation and Vasomotor Reactivity in Sporadic Alzheimer’s Disease

(2014) Aisha Abeelen et al.   Current Alzheimer Research

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytic Gq-GPCR-Linked IP3R-Dependent Ca2+ Signaling Does Not Mediate Neurovascular Coupling in Mouse Visual Cortex In Vivo

(2014) D. E. Bonder et al.   JOURNAL OF NEUROSCIENCE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Calcium dynamics in astrocyte processes during neurovascular coupling

(2014) Yo Otsu et al.   NATURE NEUROSCIENCE

Recommendations of the Alzheimer's Disease-Related Dementias Conference

(2014) T. J. Montine et al.   NEUROLOGY

Functional Brain Connectivity Using fMRI in Aging and Alzheimer’s Disease

(2014) Emily L. Dennis et al.   NEUROPSYCHOLOGY REVIEW

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Amyloid Angiopathy Increases Susceptibility to Infarction After Focal Cerebral Ischemia in Tg2576 Mice

(2014) Eric Milner et al.   STROKE

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

(2014) L. Park et al.   Nature Communications

Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue

(2014) Sava Sakadžić et al.   Nature Communications

β-amyloid deposition is shifted to the vasculature and memory impairment is exacerbated when hyperhomocysteinemia is induced in APP/PS1 transgenic mice

(2014) Tiffany L Sudduth et al.   Alzheimers Research & Therapy

A Critical Role for the Vascular Endothelium in Functional Neurovascular Coupling in the Brain

(2014) Brenda R. Chen et al.   Journal of the American Heart Association

Functional Connectivity in Autosomal Dominant and Late-Onset Alzheimer Disease

(2014) Jewell B. Thomas et al.   JAMA Neurology

Hypertension

(2013) Giuseppe Faraco et al.   HYPERTENSION

Induction of Hyperhomocysteinemia Models Vascular Dementia by Induction of Cerebral Microhemorrhages and Neuroinflammation

(2013) Tiffany L Sudduth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension

(2013) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase

(2013) K. Nizar et al.   JOURNAL OF NEUROSCIENCE

Purinergic control of vascular tone in the retina

(2013) Joanna Kur et al.   JOURNAL OF PHYSIOLOGY-LONDON

Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Impaired default network functional connectivity in autosomal dominant Alzheimer disease

(2013) J. P. Chhatwal et al.   NEUROLOGY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses

(2013) K. M. Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

(2013) Mariel G. Kozberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate-Dependent Neuroglial Calcium Signaling Differs Between Young and Adult Brain

(2013) W. Sun et al.   SCIENCE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Effectiveness of regional DTI measures in distinguishing Alzheimer's disease, MCI, and normal aging

(2013) Talia M. Nir et al.   NeuroImage-Clinical

Clinical and multimodal biomarker correlates of ADNI neuropathological findings

(2013) Jon B Toledo et al.   Acta Neuropathologica Communications

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

(2012) Ethan A. Winkler et al.   ACTA NEUROPATHOLOGICA

Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy

(2012) Andrew Dumas et al.   ANNALS OF NEUROLOGY

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

Biophysical and Physiological Origins of Blood Oxygenation Level-Dependent fMRI Signals

(2012) Seong-Gi Kim et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The Locus Coeruleus-Norepinephrine Network Optimizes Coupling of Cerebral Blood Volume with Oxygen Demand

(2012) Lane K Bekar et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood–Spinal Cord Barrier Pericyte Reductions Contribute to Increased Capillary Permeability

(2012) Ethan A Winkler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Central Cardiovascular Circuits Contribute to the Neurovascular Dysfunction in Angiotensin II Hypertension

(2012) C. Capone et al.   JOURNAL OF NEUROSCIENCE

The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy

(2012) Stavros J. Baloyannis et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

A brief history of the resting state: The Washington University perspective

(2012) Abraham Z. Snyder et al.   NEUROIMAGE

Neuronal inhibition and excitation, and the dichotomic control of brain hemodynamic and oxygen responses

(2012) Martin Lauritzen et al.   NEUROIMAGE

Pericytes as a new target for pathological processes in CADASIL

(2012) Dorota Dziewulska et al.   NEUROPATHOLOGY

S Phase Entry of Neural Progenitor Cells Correlates with Increased Blood Flow in the Young Subventricular Zone

(2012) Benjamin Lacar et al.   PLoS One

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

(2012) D. Lovatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Lactate dilates cochlear capillaries via type V fibrocyte-vessel coupling signaled by nNOS

(2011) Min Dai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

"Overshoot" of O2 Is Required to Maintain Baseline Tissue Oxygenation at Locations Distal to Blood Vessels

(2011) A. Devor et al.   JOURNAL OF NEUROSCIENCE

Non-linear relationship between hyperpolarisation and relaxation enables long distance propagation of vasodilatation

(2011) Stephanie E. Wölfle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

(2011) Y. Chen et al.   NEUROLOGY

Oxygen modulation of neurovascular coupling in the retina

(2011) A. Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid- 

(2011) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–Brain Barrier Permeability Abnormalities in Vascular Cognitive Impairment

(2011) Saeid Taheri et al.   STROKE

The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension

(2010) Carmen Capone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

(2010) Madhav Thambisetty et al.   ARCHIVES OF NEUROLOGY

Two-Photon NADH Imaging Exposes Boundaries of Oxygen Diffusion in Cortical Vascular Supply Regions

(2010) Karl A Kasischke et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β-peptide elimination from the brain

(2010) Berislav V. Zlokovic et al.   JOURNAL OF NEUROCHEMISTRY

APOE4 Allele Disrupts Resting State fMRI Connectivity in the Absence of Amyloid Plaques or Decreased CSF A 42

(2010) Y. I. Sheline et al.   JOURNAL OF NEUROSCIENCE

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease

(2010) Uma S. Yezhuvath et al.   NEUROBIOLOGY OF AGING

High-speed vascular dynamics of the hemodynamic response

(2010) Brenda R. Chen et al.   NEUROIMAGE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex

(2010) A.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

(2010) F. Fernandez-Klett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction

(2010) Hélène Girouard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal

(2010) P. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament

(2009) Min Dai et al.   HEARING RESEARCH

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Blood–brain barrier permeability in Alzheimer's disease: a case–control MRI study

(2009) John M. Starr et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Brain metabolism dictates the polarity of astrocyte control over arterioles

(2008) Grant R. J. Gordon et al.   NATURE

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

(2008) Robert D. Bell et al.   NATURE CELL BIOLOGY

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON