Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function

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(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

The effects of A1/A2 astrocytes on oligodendrocyte linage cells against white matter injury under prolonged cerebral hypoperfusion

(2020) Nobukazu Miyamoto et al.   GLIA

Modulation of brain cation-Cl− cotransport via the SPAK kinase inhibitor ZT-1a

(2020) Jinwei Zhang et al.   Nature Communications

An Inhibitor of the Sodium–Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia

(2020) Beom Seok Kang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

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Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration

(2020) Sudeshna Das et al.   Journal of Neuroinflammation

Crosstalk Between Astrocytes and Microglia: An Overview

(2020) Agata Matejuk et al.   Frontiers in Immunology

White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial

(2020) Ruth Stephen et al.   JOURNAL OF ALZHEIMERS DISEASE

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

(2020) Heejung Chun et al.   NATURE NEUROSCIENCE

Activation of endothelial Wnt/β-catenin signaling by protective astrocytes repairs BBB damage in ischemic stroke

(2020) Shanshan Song et al.   PROGRESS IN NEUROBIOLOGY

A Review and Hypothesized Model of the Mechanisms That Underpin the Relationship Between Inflammation and Cognition in the Elderly

(2019) Masoumeh Tangestani Fard et al.   Frontiers in Aging Neuroscience

Glial activation and inflammation along the Alzheimer’s disease continuum

(2019) Kaja Nordengen et al.   Journal of Neuroinflammation

Sodium/Hydrogen Exchanger 1 Participates in Early Brain Injury after Subarachnoid Hemorrhage both in vivo and in vitro via Promoting Neuronal Apoptosis

(2019) Huangcheng Song et al.   CELL TRANSPLANTATION

A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure

(2019) Adam M. Staffaroni et al.   HUMAN BRAIN MAPPING

Influence of different isoflurane anesthesia protocols on murine cerebral hemodynamics measured with pseudo‐continuous arterial spin labeling

(2019) Leon P. Munting et al.   NMR IN BIOMEDICINE

Inflammation and cerebral small vessel disease: A systematic review

(2019) Audrey Low et al.   AGEING RESEARCH REVIEWS

Roles of glial ion transporters in brain diseases

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Protective Role of Levetiracetam Against Cognitive Impairment And Brain White Matter Damage in Mouse prolonged Cerebral Hypoperfusion

(2019) Toshiki Inaba et al.   NEUROSCIENCE

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion

(2018) Jun Miyanohara et al.   JOURNAL OF NEUROSCIENCE

Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice

(2018) Jill M. Roberts et al.   PLoS One

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective role of Na+ /H+ exchanger in Cx3cr1+ microglial activation, white matter demyelination, and post-stroke function recovery

(2018) Shanshan Song et al.   GLIA

Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

(2018) Xiudong Guan et al.   Cell Death & Disease

In vivo Imaging of Glial Activation in Alzheimer's Disease

(2018) Paul Edison et al.   Frontiers in Neurology

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

(2018) Gene L. Bowman et al.   Alzheimers & Dementia

Selective knockout of astrocytic Na+ /H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke

(2017) Gulnaz Begum et al.   GLIA

Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood–brain barrier permeability in the corpus callosum

(2017) Qinghai Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination

(2017) Hedwich F. Kuipers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble epoxide hydrolase inhibition Promotes White Matter Integrity and Long-Term Functional Recovery after chronic hypoperfusion in mice

(2017) Yuxue Chen et al.   Scientific Reports

Regulation of Cognitive Processing by Hippocampal Cholinergic Tone

(2016) Mohammed A. Al-Onaizi et al.   CEREBRAL CORTEX

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

(2016) Kyoungho Suk   PROGRESS IN NEUROBIOLOGY

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats

(2015) Mercedes Muñoz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ecto-5′-nucleotidase (CD73) is involved in chronic cerebral hypoperfusion-induced white matter lesions and cognitive impairment by regulating glial cell activation and pro-inflammatory cytokines

(2015) X. Hou et al.   NEUROSCIENCE

Sustained Na+/H+ Exchanger Activation Promotes Gliotransmitter Release from Reactive Hippocampal Astrocytes following Oxygen-Glucose Deprivation

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Global Epidemiology of Dementia: Alzheimer’s and Vascular Types

(2014) Liara Rizzi et al.   Biomed Research International

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Intracellular pH reduction prevents excitotoxic and ischemic neuronal death by inhibiting NADPH oxidase

(2013) T. I. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral Hypoperfusion During Carotid Artery Stenosis can Lead to Cognitive Deficits that may be Independent of White Matter Lesion Load

(2012) Martin Scherr et al.   CURRENT NEUROVASCULAR RESEARCH

Intravenous HOE-642 Reduces Brain Edema and Na Uptake in the Rat Permanent Middle Cerebral Artery Occlusion Model of Stroke: Evidence for Participation of the Blood–Brain Barrier Na/H Exchanger

(2012) Martha E O'Donnell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections

(2011) Matthew D. Budde et al.   BRAIN

Chronic Neurological Deficits in Mice after Perinatal Hypoxia and Ischemia Correlate with Hemispheric Tissue Loss and White Matter Injury Detected by MRI

(2011) Pelin Cengiz et al.   DEVELOPMENTAL NEUROSCIENCE

Role of sodium/hydrogen exchanger isoform 1 in microglial activation and proinflammatory responses in ischemic brains

(2011) Yejie Shi et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Na+/H+ Exchanger Isoform 1 Is Neuroprotective in Neonatal Hypoxic Ischemic Brain Injury

(2010) Pelin Cengiz et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of Microglia Depends on Na+/H+ Exchange-Mediated H+ Homeostasis

(2010) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Dose-dependent effect of isoflurane on neurovascular coupling in rat cerebral cortex

(2009) Kazuto Masamoto et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart

(2009) Carolina D. Garciarena et al.   JOURNAL OF APPLIED PHYSIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Carotid Artery Atherosclerosis, MRI Indices of Brain Ischemia, Aging, and Cognitive Impairment

(2009) José R. Romero et al.   STROKE

Astroglial and cognitive effects of chronic cerebral hypoperfusion in the rat

(2008) Évelin Vicente et al.   BRAIN RESEARCH

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox

(2008) Houssam Raad et al.   FASEB JOURNAL

Cyclooxygenase-2 Expression and Prostaglandin E2 Production in Response to Acidic pH Through OGR1 in a Human Osteoblastic Cell Line

(2008) Hideaki Tomura et al.   JOURNAL OF BONE AND MINERAL RESEARCH