Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

Astrocytes are central in the pathomechanisms of vanishing white matter

(2016) Stephanie Dooves et al.   JOURNAL OF CLINICAL INVESTIGATION

Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System

(2016) B.-W. Kim et al.   JOURNAL OF NEUROSCIENCE

Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan

(2016) Xiaofeng Xu et al.   MOLECULAR NEUROBIOLOGY

Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective

(2016) Kyoungho Suk   PROGRESS IN NEUROBIOLOGY

Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

(2015) Candice Chapouly et al.   BRAIN

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke

(2015) Jun Suenaga et al.   EXPERIMENTAL NEUROLOGY

Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia

(2015) Yao Qi et al.   GLIA

Gliovascular Disruption and Cognitive Deficits in a Mouse Model with Features of Small Vessel Disease

(2015) Philip R Holland et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hypoxia-Induced Neuroinflammatory White-Matter Injury Reduced by Minocycline in SHR/SP

(2015) Fakhreya Y Jalal et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes Promote Oligodendrogenesis after White Matter Damage via Brain-Derived Neurotrophic Factor

(2015) N. Miyamoto et al.   JOURNAL OF NEUROSCIENCE

Vascular dementia

(2015) John T O'Brien et al.   LANCET

Hippocampal volume and shape in pure subcortical vascular dementia

(2015) Geon Ha Kim et al.   NEUROBIOLOGY OF AGING

Blood-brain barrier damage in vascular dementia

(2015) Masaki Ueno et al.   NEUROPATHOLOGY

From the periphery to the brain: Lipocalin-2, a friend or foe?

(2015) Ana C. Ferreira et al.   PROGRESS IN NEUROBIOLOGY

Long-Term Blood–Brain Barrier Permeability Changes in Binswanger Disease

(2015) Branko N. Huisa et al.   STROKE

Neurobehavioral and Imaging Correlates of Hippocampal Atrophy in a Mouse Model of Vascular Cognitive Impairment

(2015) Kristen L. Zuloaga et al.   Translational Stroke Research

Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type

(2014) H. J. Kim et al.   EUROPEAN JOURNAL OF NEUROLOGY

The pivotal role played by lipocalin-2 in chronic inflammatory pain

(2014) Mithilesh Kumar Jha et al.   EXPERIMENTAL NEUROLOGY

Use of labeled tomato lectin for imaging vasculature structures

(2014) Richard T. Robertson et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis

(2014) Youngpyo Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipocalin-2 Deficiency Attenuates Neuroinflammation and Brain Injury after Transient Middle Cerebral Artery Occlusion in Mice

(2014) Myungwon Jin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chronic Sleep Deprivation-Induced Proteome Changes in Astrocytes of the Rat Hypothalamus

(2014) Jae-Hong Kim et al.   JOURNAL OF PROTEOME RESEARCH

The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders

(2014) W K Jo et al.   MOLECULAR PSYCHIATRY

A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

(2014) Sanghee Lee et al.   Nature Chemical Biology

Astrocyte-Derived Proinflammatory Cytokines Induce Hypomyelination in the Periventricular White Matter in the Hypoxic Neonatal Brain

(2014) Yiyu Deng et al.   PLoS One

Lipocalin-2 is involved in emotional behaviors and cognitive function

(2014) Ana Ferreira   Frontiers in Cellular Neuroscience

Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice

(2014) Yang Zhao et al.   Frontiers in Aging Neuroscience

Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness

(2014) Bharathi Hattiangady et al.   Frontiers in Behavioral Neuroscience

Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats

(2013) Ming Dong et al.   BRAIN RESEARCH

Role of Lipocalin-2-Chemokine Axis in the Development of Neuropathic Pain following Peripheral Nerve Injury

(2013) Sangmin Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Models to Study the Effect of Cardiovascular Risk Factors on Brain Structure and Cognition

(2013) Diewertje I Bink et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes

(2013) E. Jang et al.   JOURNAL OF IMMUNOLOGY

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

The Pathobiology of Vascular Dementia

(2013) Costantino Iadecola   NEURON

Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

(2013) Scott E. Counts et al.   NEUROPHARMACOLOGY

Reactive astrocytes secrete lcn2 to promote neuron death

(2013) F. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease

(2012) Petrus J. W. Naudé et al.   FASEB JOURNAL

Secreted protein lipocalin-2 promotes microglial M1 polarization

(2012) Eunha Jang et al.   FASEB JOURNAL

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment

(2011) Fernanda Cechetti et al.   BRAIN RESEARCH BULLETIN

Lipocalin-2 Is a Chemokine Inducer in the Central Nervous System

(2011) Shinrye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipocalin 2 Plays an Immunomodulatory Role and Has Detrimental Effects after Spinal Cord Injury

(2011) K. I. Rathore et al.   JOURNAL OF NEUROSCIENCE

Regulation by lipocalin-2 of neuronal cell death, migration, and morphology

(2011) Shinrye Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Hippocampal Atrophy in Subcortical Vascular Dementia

(2011) Laura van de Pol et al.   Neurodegenerative Diseases

Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation

(2011) M. Mucha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blood–Brain Barrier Permeability Abnormalities in Vascular Cognitive Impairment

(2011) Saeid Taheri et al.   STROKE

Neurocognitive Improvement After Carotid Artery Stenting in Patients With Chronic Internal Carotid Artery Occlusion and Cerebral Ischemia

(2011) Mao-Shin Lin et al.   STROKE

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Vascular risk factor detection and control may prevent Alzheimer's disease

(2010) Jack C. de la Torre   AGEING RESEARCH REVIEWS

Experimental models of vascular dementia and vascular cognitive impairment: a systematic review

(2010) Nadim S. Jiwa et al.   JOURNAL OF NEUROCHEMISTRY

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

(2010) Robert D. Bell et al.   NEURON

Microglia transplantation attenuates white matter injury in rat chronic ischemia model via matrix metalloproteinase-2 inhibition

(2009) Dashdemberel Narantuya et al.   BRAIN RESEARCH

Hydrogen sulphide protects H9c2 cells against chemical hypoxia-induced injury

(2009) Si-Lin Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

(2009) S. Lee et al.   JOURNAL OF NEUROSCIENCE

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1 

(2008) S. H. Li et al.   MOLECULAR CANCER THERAPEUTICS

The hippocampus and memory: insights from spatial processing

(2008) Chris M. Bird et al.   NATURE REVIEWS NEUROSCIENCE

Inflammation and White Matter Damage in Vascular Cognitive Impairment

(2008) G. A. Rosenberg   STROKE

Chronic cerebral hypoperfusion induced by right unilateral common carotid artery occlusion causes delayed white matter lesions and cognitive impairment in adult mice

(2007) Kaichi Yoshizaki et al.   EXPERIMENTAL NEUROLOGY

Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats

(2007) X KUANG et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR