mTOR drives cerebral blood flow and memory deficits in LDLR−/− mice modeling atherosclerosis and vascular cognitive impairment

Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

(2016) Ying Ann Chiao et al.   Aging-US

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

(2015) Emma L. Baar et al.   AGING CELL

Glutaredoxin 2a overexpression in macrophages promotes mitochondrial dysfunction but has little or no effect on atherogenesis in LDL-receptor null mice

(2015) D.A. Zamora et al.   ATHEROSCLEROSIS

Potential therapeutic effects of mTOR inhibition in atherosclerosis

(2015) Ammar Kurdi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

mTOR inhibitors and dyslipidemia in transplant recipients: A cause for concern?

(2015) Hallvard Holdaas et al.   Transplantation Reviews

Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice

(2015) Simon C. Johnson et al.   Frontiers in Genetics

Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life

(2015) Kathleen E. Fischer et al.   PLoS One

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

(2014) Scott A. Barman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

mTOR inhibition: A promising strategy for stabilization of atherosclerotic plaques

(2014) Wim Martinet et al.   ATHEROSCLEROSIS

Cardiovascular risk factors and future risk of Alzheimer’s disease

(2014) Renée FAG de Bruijn et al.   BMC Medicine

Impaired compensatory beta-cell function and growth in response to high-fat diet in LDL receptor knockout mice

(2014) Ricardo B. d. Oliveira et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Testing Efficacy of Administration of the Antiaging Drug Rapamycin in a Nonhuman Primate, the Common Marmoset

(2014) Suzette Tardif et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Single Rapamycin Administration Induces Prolonged Downward Shift in Defended Body Weight in Rats

(2014) Mark Hebert et al.   PLoS One

An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice

(2014) Nan Peng et al.   Scientific Reports

Metabolic complications with the use of mTOR inhibitors for cancer therapy

(2013) Shanthi Sivendran et al.   CANCER TREATMENT REVIEWS

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

Knockdown of mTOR by lentivirus-mediated RNA interference suppresses atherosclerosis and stabilizes plaques via a decrease of macrophages by autophagy in apolipoprotein E-deficient mice

(2013) XIAOCHUANG WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

(2013) Ai-Ling Lin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rapamycin Extends Life and Health in C57BL/6 Mice

(2013) Yiqiang Zhang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome

(2013) S. C. Johnson et al.   SCIENCE

Rapamycin slows aging in mice

(2012) John E. Wilkinson et al.   AGING CELL

Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice

(2012) J. Halloran et al.   NEUROSCIENCE

Exercise, brain, and cognition across the life span

(2011) Michelle W. Voss et al.   JOURNAL OF APPLIED PHYSIOLOGY

Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress

(2011) J. de Oliveira et al.   NEUROSCIENCE

Chronic intermittent cold stress sensitizes neuro-immune reactivity in the rat brain

(2011) Milena Girotti et al.   PSYCHONEUROENDOCRINOLOGY

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Low-dose oral sirolimus reduces atherogenesis, vascular inflammation and modulates plaque composition in mice lacking the LDL receptor

(2009) L Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel cerebrovascular pathology in mice fed a high cholesterol diet

(2009) Sonia Franciosi et al.   Molecular Neurodegeneration

Cardiovascular risk factors and dementia

(2008) Howard Fillit et al.   American Journal Geriatric Pharmacotherapy

Increased locomotor activity in mice lacking the low-density lipoprotein receptor

(2008) Gregory A. Elder et al.   BEHAVIOURAL BRAIN RESEARCH

Antidepressive-like effects of rapamycin in animal models: Implications for mTOR inhibition as a new target for treatment of affective disorders

(2008) C. Cleary et al.   BRAIN RESEARCH BULLETIN

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR−/− mice despite severe hypercholesterolemia

(2007) Marc A. Mueller et al.   ATHEROSCLEROSIS

Be smart, exercise your heart: exercise effects on brain and cognition

(2007) Charles H. Hillman et al.   NATURE REVIEWS NEUROSCIENCE