The integration of spheroids and organoids into organ-on-a-chip platforms for tumour research: A review

Translational organoid technology – the convergence of chemical, mechanical, and computational biology

(2022) Weijie Zhang et al.   TRENDS IN BIOTECHNOLOGY

Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro

(2022) Perizat Kanabekova et al.   Micromachines

Recent trends of biomaterials and biosensors for organ-on-chip platforms

(2022) Inês M. Gonçalves et al.   Bioprinting

Organ-on-a-chip platforms as novel advancements for studying heterogeneity, metastasis, and drug efficacy in breast cancer

(2022) Rita Kalot et al.   PHARMACOLOGY & THERAPEUTICS

Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues

(2021) Ross Burdis et al.   Acta Biomaterialia

Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling

(2021) Su Kyeom Kim et al.   Acta Biomaterialia

Breast tumor-on-chip models: From disease modeling to personalized drug screening

(2021) Bano Subia et al.   JOURNAL OF CONTROLLED RELEASE

Modeling the Human Body on Microfluidic Chips

(2021) Sasan Jalili-Firoozinezhad et al.   TRENDS IN BIOTECHNOLOGY

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

(2021) Andrew C. Daly et al.   Nature Communications

Three-dimensional bioprinting adipose tissue and mammary Organoids feasible for artificial breast structure regeneration

(2021) Yutong Chen et al.   MATERIALS & DESIGN

Organoid and Spheroid Tumor Models: Techniques and Applications

(2021) Sreenivasulu Gunti et al.   Cancers

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

(2021) Pauline Zamprogno et al.   Communications Biology

Tumor-on-chip modeling of organ-specific cancer and metastasis

(2021) Nuala Del Piccolo et al.   ADVANCED DRUG DELIVERY REVIEWS

Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids

(2021) Ary Marsee et al.   Cell Stem Cell

3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review

(2021) Violeta Carvalho et al.   SENSORS

Tumor organoids: Opportunities and challenges to guide precision medicine

(2021) Vivien Veninga et al.   CANCER CELL

A Gut-Brain Axis-on-a-Chip for studying transport across epithelial and endothelial barriers

(2021) Min-Hyeok Kim et al.   JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Liver organoid as a 3D in vitro model for drug validation and toxicity assessment

(2021) Anastasia Brooks et al.   PHARMACOLOGICAL RESEARCH

Diversity Models and Applications of 3D Breast Tumor-on-a-Chip

(2021) Kena Song et al.   Micromachines

Engineering Breast Cancer On-chip—Moving Toward Subtype Specific Models

(2021) Carmen Moccia et al.   Frontiers in Bioengineering and Biotechnology

Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform

(2021) Unnati Modi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

(2020) Yadir A. Guerrero et al.   AAPS Journal

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Towards chamber specific heart-on-a-chip for drug testing applications

(2020) Yimu Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Indirect co-culture of lung carcinoma cells with hyperthermia-treated mesenchymal stem cells influences tumor spheroid growth in a collagen-based 3-dimensional microfluidic model

(2020) Nandini Dhiman et al.   CYTOTHERAPY

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shear Stress-Dependent Targeting Efficiency Using Self-Assembled Gelatin–Oleic Nanoparticles in a Biomimetic Microfluidic System

(2020) Taehee Kang et al.   Pharmaceutics

Three-Dimensional Human Liver-Chip Emulating Premetastatic Niche Formation by Breast Cancer-Derived Extracellular Vesicles

(2020) Junyoung Kim et al.   ACS Nano

Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips

(2020) Dongdong Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Promising Applications of Tumor Spheroids and Organoids for Personalized Medicine

(2020) Zarema Gilazieva et al.   Cancers

A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices

(2020) Begum Gokce et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

(2020) Ameen A. Salahudeen et al.   NATURE

Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine

(2020) Raquel O. Rodrigues et al.   Small

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

(2020) Yaqiong Guo et al.   Science Bulletin

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Engineering Microfluidic Organoid-on-a-Chip Platforms

(2019) Fang Yu et al.   Micromachines

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

(2019) Jasper Mullenders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human-Derived Organ-on-a-Chip for Personalized Drug Development

(2019) Yasamin A. Jodat et al.   CURRENT PHARMACEUTICAL DESIGN

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Microfluidics for studying metastatic patterns of lung cancer

(2019) Monika Ruzycka et al.   JOURNAL OF NANOBIOTECHNOLOGY

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

(2019) M. R. Carvalho et al.   Science Advances

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

(2019) DoYeun Park et al.   TRENDS IN BIOTECHNOLOGY

A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies

(2019) Michelle Maurer et al.   BIOMATERIALS

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

(2019) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Long-term monitoring in a microfluidic system to study tumour spheroid response to chronic and cycling hypoxia

(2019) Samantha M. Grist et al.   Scientific Reports

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment

(2019) Muhammad Asad Ullah Khalid et al.   BIOCHEMICAL ENGINEERING JOURNAL

A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models

(2019) Ludivine C. Delon et al.   BIOMATERIALS

Transparent cellulose nanofiber based open cell culture platform using matrix-assisted 3D printing

(2019) Sungchul Shin et al.   CARBOHYDRATE POLYMERS

Human Induced Pluripotent Stem-Cardiac-Endothelial-Tumor-on-a-Chip to Assess Anticancer Efficacy and Cardiotoxicity

(2019) Kuo-Chan Weng et al.   TISSUE ENGINEERING PART C-METHODS

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Development of a functional thyroid model based on an organoid culture system

(2018) Yoshiyuki Saito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

(2018) Xingyuan Yang et al.   LAB ON A CHIP

Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice

(2018) Zhongyu Li et al.   TOXICOLOGY IN VITRO

Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model

(2018) Molly M. Morgan et al.   Scientific Reports

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids

(2018) Jiyoon Lee et al.   Cell Reports

Engineered 3D tumour model for study of glioblastoma aggressiveness and drug evaluation on a detachably assembled microfluidic device

(2018) Jingyun Ma et al.   BIOMEDICAL MICRODEVICES

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

(2018) Siming Lu et al.   LAB ON A CHIP

Beyond the on/off chip trade-off: A reversibly sealed microfluidic platform for 3D tumor microtissue analysis

(2018) Gabriele Pitingolo et al.   SENSORS AND ACTUATORS B-CHEMICAL

Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

(2018) Juliane Hübner et al.   Scientific Reports

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Construction of a 3D mammary duct based on spatial localization of the extracellular matrix

(2018) Youngkyu Cho et al.   NPG Asia Materials

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines

(2018) Jiho Song et al.   Scientific Reports

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

(2018) Marie Nguyen et al.   Cell Reports

Studies on effectiveness of PTT on 3D tumor model under microfluidic conditions using aptamer-modified nanoshells

(2018) Dominika Kalinowska et al.   BIOSENSORS & BIOELECTRONICS

Bioaccessibility and antioxidant activity of free phenolic compounds and oligosaccharides from corn ( Zea mays L.) and common bean ( Phaseolus vulgaris L.) chips during in vitro gastrointestinal digestion and simulated colonic fermentation

(2017) I. Luzardo-Ocampo et al.   FOOD RESEARCH INTERNATIONAL

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation

(2017) Mingsha Jie et al.   Science China-Chemistry

Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro

(2017) Ken-ichiro Kamei et al.   RSC Advances

Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models

(2017) María Virumbrales-Muñoz et al.   Scientific Reports

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

In situ , dual-mode monitoring of organ-on-a-chip with smartphone-based fluorescence microscope

(2016) Soohee Cho et al.   BIOSENSORS & BIOELECTRONICS

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

(2016) Zhongyu Li et al.   Integrative Biology

Heterotypic 3D tumor culture in a reusable platform using pneumatic microfluidics

(2016) Wenming Liu et al.   LAB ON A CHIP

Rapid formation of size-controllable multicellular spheroids via 3D acoustic tweezers

(2016) Kejie Chen et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Development of complex-shaped liver multicellular spheroids as a human-based model for nanoparticle toxicity assessment in vitro

(2016) Monika Dubiak-Szepietowska et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Towards Single-Step Biofabrication of Organs on a Chip via 3D Printing

(2016) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

(2016) Manuela Völkner et al.   Stem Cell Reports

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Monitoring Tumor Response to Anticancer Drugs Using Stable Three-Dimensional Culture in a Recyclable Microfluidic Platform

(2015) Wenming Liu et al.   ANALYTICAL CHEMISTRY

Alginate core-shell beads for simplified three-dimensional tumor spheroid culture and drug screening

(2015) Linfen Yu et al.   BIOMEDICAL MICRODEVICES

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Emulating human microcapillaries in a multi-organ-chip platform

(2015) Tobias Hasenberg et al.   JOURNAL OF BIOTECHNOLOGY

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Cancer Associated Fibroblast-Derived Hepatocyte Growth Factor Inhibits the Paclitaxel-Induced Apoptosis of Lung Cancer A549 Cells by Up-Regulating the PI3K/Akt and GRP78 Signaling on a Microfluidic Platform

(2015) Li Ying et al.   PLoS One

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Tumor-bowel fistula: what radiologists should know

(2013) Sree Harsha Tirumani et al.   ABDOMINAL IMAGING

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system

(2012) Liang Ma et al.   BIOMATERIALS

Microfluidic experimental platform for producing size-controlled three-dimensional spheroids

(2011) Hiroki Ota et al.   SENSORS AND ACTUATORS A-PHYSICAL

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Scaffold-free vascular tissue engineering using bioprinting

(2009) Cyrille Norotte et al.   BIOMATERIALS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE