Tumor organoids: Opportunities and challenges to guide precision medicine

Genetic engineering in organoids

(2021) Isaree Teriyapirom et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries

(2021) Tejeshwar Jain et al.   Frontiers in Immunology

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma

(2021) Krijn K. Dijkstra et al.   Frontiers in Endocrinology

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

(2021) Bas Ponsioen et al.   NATURE CELL BIOLOGY

Prospective experimental treatment of colorectal cancer patients based on organoid drug responses

(2021) S.N. Ooft et al.   ESMO Open

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

(2020) Cayetano Pleguezuelos-Manzano et al.   NATURE

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

(2020) Till Ringel et al.   Cell Stem Cell

Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy

(2020) Vignesh Narasimhan et al.   CLINICAL CANCER RESEARCH

The DNA methylation landscape of human cancer organoids available at the American type culture collection

(2020) Ricky Joshi et al.   Epigenetics

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

(2020) Kyuho Han et al.   NATURE

Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers

(2020) Myriam Chalabi et al.   NATURE MEDICINE

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

(2020) Krijn K. Dijkstra et al.   Cell Reports

An organoid-based drug screening identified a menin-MLL inhibitor for endometrial cancer through regulating the HIF pathway

(2020) Jingyao Chen et al.   CANCER GENE THERAPY

Organoid Models of Tumor Immunology

(2020) Kanako Yuki et al.   TRENDS IN IMMUNOLOGY

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

(2020) Chris Jenske de Witte et al.   Cell Reports

Cancer research using organoid technology

(2020) Kai Kretzschmar   JOURNAL OF MOLECULAR MEDICINE-JMM

Single-Cell Proteomics: Progress and Prospects

(2020) Ryan T. Kelly   MOLECULAR & CELLULAR PROTEOMICS

Single-cell derived tumor organoids display diversity in HLA class I peptide presentation

(2020) Laura C. Demmers et al.   Nature Communications

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis

(2019) Gitte Berkers et al.   Cell Reports

Mouse and human urothelial cancer organoids: A tool for bladder cancer research

(2019) Jasper Mullenders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

(2019) Lara Planas-Paz et al.   Cell Stem Cell

3D model for CAR‐mediated cytotoxicity using patient‐derived colorectal cancer organoids

(2019) Theresa E Schnalzger et al.   EMBO JOURNAL

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids

(2019) Reyes Gonzalez-Exposito et al.   Journal for ImmunoTherapy of Cancer

Application of Cancer Organoid Model for Drug Screening and Personalized Therapy

(2019) Jumpei Kondo et al.   Cells

Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma

(2019) Antoni Ribas et al.   NATURE MEDICINE

Clonal replacement of tumor-specific T cells following PD-1 blockade

(2019) Kathryn E. Yost et al.   NATURE MEDICINE

CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genes

(2019) Haruna Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomics of Melanoma Response to Immunotherapy Reveals Mitochondrial Dependence

(2019) Michal Harel et al.   CELL

Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

(2019) Ye Yao et al.   Cell Stem Cell

A rectal cancer organoid platform to study individual responses to chemoradiation

(2019) Karuna Ganesh et al.   NATURE MEDICINE

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

(2019) Fadi Jacob et al.   CELL

Tumor organoid–T-cell coculture systems

(2019) Chiara M. Cattaneo et al.   Nature Protocols

Pancreatic cancer organoids recapitulate disease and allow personalized drug screening

(2019) Else Driehuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimation of clinical trial success rates and related parameters

(2018) Chi Heem Wong et al.   BIOSTATISTICS

Development of primary human pancreatic cancer organoids, matched stromal and immune cells and 3D tumor microenvironment models

(2018) Susan Tsai et al.   BMC CANCER

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

(2018) Takashi Seino et al.   Cell Stem Cell

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Patient derived organoids to model rare prostate cancer phenotypes

(2018) Loredana Puca et al.   Nature Communications

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

The role of proteomics in the age of immunotherapies

(2018) Sarah A. Hayes et al.   MAMMALIAN GENOME

Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

(2018) Xiaodun Li et al.   Nature Communications

Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids

(2018) Sarah J. Hill et al.   Cancer Discovery

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening

(2018) Helen H.N. Yan et al.   Cell Stem Cell

Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification

(2018) Brendan Bulik-Sullivan et al.   NATURE BIOTECHNOLOGY

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Phenotypic Analysis of Organoids by Proteomics

(2017) Alexis Gonneaud et al.   PROTEOMICS

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine

(2017) Chantal Pauli et al.   Cancer Discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Primary Patient-Derived Cancer Cells and Their Potential for Personalized Cancer Patient Care

(2017) David P. Kodack et al.   Cell Reports

Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

(2017) Alba Cristobal et al.   Cell Reports

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Tissue-specific mutation accumulation in human adult stem cells during life

(2016) Francis Blokzijl et al.   NATURE

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

TBCRC009: A Multicenter Phase II Clinical Trial of Platinum Monotherapy With Biomarker Assessment in Metastatic Triple-Negative Breast Cancer

(2015) Steven J. Isakoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids

(2015) Mami Matano et al.   NATURE MEDICINE

Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases

(2015) Fleur Weeber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Organoid cultures for the analysis of cancer phenotypes

(2014) Norman Sachs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Self-formation of layered neural structures in three-dimensional culture of ES cells

(2012) Mototsugu Eiraku et al.   CURRENT OPINION IN NEUROBIOLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY