Engineering Microfluidic Organoid-on-a-Chip Platforms

Microfluidic platforms for modeling biological barriers in the circulatory system

(2018) Fang Yu et al.   DRUG DISCOVERY TODAY

Organ/body-on-a-chip based on microfluidic technology for drug discovery

(2018) Hiroshi Kimura et al.   Drug Metabolism and Pharmacokinetics

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Human brain organoids on a chip reveal the physics of folding

(2018) Eyal Karzbrun et al.   Nature Physics

Organ-Derived Decellularized Extracellular Matrix: A Game Changer for Bioink Manufacturing?

(2018) Deepak Choudhury et al.   TRENDS IN BIOTECHNOLOGY

Engineering stem cell-derived 3D brain organoids in a perfusable organ-on-a-chip system

(2018) Yaqing Wang et al.   RSC Advances

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

(2018) Magdalena Kasendra et al.   Scientific Reports

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

(2017) Li Wang et al.   LAB ON A CHIP

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing

(2017) Miguel Crespo et al.   NATURE MEDICINE

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Modeling in Stem Cell-Derived 3D Organoid Systems

(2017) Devanjali Dutta et al.   TRENDS IN MOLECULAR MEDICINE

Wet-AMD on a Chip: Modeling Outer Blood-Retinal Barrier In Vitro

(2017) Minhwan Chung et al.   Advanced Healthcare Materials

A perfusion incubator liver chip for 3D cell culture with application on chronic hepatotoxicity testing

(2017) Fang Yu et al.   Scientific Reports

Constrained spheroids for prolonged hepatocyte culture

(2016) Wen Hao Tong et al.   BIOMATERIALS

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

(2016) Hyuna Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Stem Cell Models of Human Brain Development

(2016) Iva Kelava et al.   Cell Stem Cell

Engineering Stem Cell Organoids

(2016) Xiaolei Yin et al.   Cell Stem Cell

Engineering a perfusable 3D human liver platform from iPS cells

(2016) Arnout Schepers et al.   LAB ON A CHIP

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

(2016) Anna Marsano et al.   LAB ON A CHIP

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

The promises and challenges of human brain organoids as models of neuropsychiatric disease

(2016) Giorgia Quadrato et al.   NATURE MEDICINE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation

(2016) Laura Broutier et al.   Nature Protocols

Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis

(2016) Manuela Völkner et al.   Stem Cell Reports

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

(2015) Da Yoon No et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3D in vitro modeling of the central nervous system

(2015) Amy M. Hopkins et al.   PROGRESS IN NEUROBIOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

(2012) Maria Vinci et al.   BMC BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Microfluidic 3D cell culture: potential application for tissue-based bioassays

(2012) XiuJun (James) Li et al.   Bioanalysis

Exploitation of physical and chemical constraints for three-dimensional microtissue construction in microfluidics

(2011) Deepak Choudhury et al.   Biomicrofluidics

Biomimetic tissues on a chip for drug discovery

(2011) Amir M. Ghaemmaghami et al.   DRUG DISCOVERY TODAY

Axon diodes for the reconstruction of oriented neuronal networks in microfluidic chambers

(2011) Jean-Michel Peyrin et al.   LAB ON A CHIP

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A Novel Flow-Perfusion Bioreactor Supports 3D Dynamic Cell Culture

(2009) Alexander M. Sailon et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

3D cell culture opens new dimensions in cell-based assays

(2008) Bradley A. Justice et al.   DRUG DISCOVERY TODAY