Translational organoid technology – the convergence of chemical, mechanical, and computational biology

Suspension culture promotes serosal mesothelial development in human intestinal organoids

(2022) Meghan M. Capeling et al.   Cell Reports

Harnessing Mechanobiology for Tissue Engineering

(2021) Sudong Kim et al.   DEVELOPMENTAL CELL

The Organoid Cell Atlas

(2021) Christoph Bock et al.   NATURE BIOTECHNOLOGY

3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics

(2021) Hyogeun Shin et al.   Nature Communications

Human heart-forming organoids recapitulate early heart and foregut development

(2021) Lika Drakhlis et al.   NATURE BIOTECHNOLOGY

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

(2021) Fotios Sampaziotis et al.   SCIENCE

Automated evaluation of tumor spheroid behavior in 3D culture using deep learning-based recognition

(2021) Zaozao Chen et al.   BIOMATERIALS

All-Tissue-like Multifunctional Optoelectronic Mesh for Deep-Brain Modulation and Mapping

(2021) Jung Min Lee et al.   NANO LETTERS

Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week

(2021) Yawei Hu et al.   Nature Communications

Three-dimensional microscale hanging drop arrays with geometric control for drug screening and live tissue imaging

(2021) A. Ganguli et al.   Science Advances

Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo

(2021) Gabriella Nilsson Hall et al.   BIOMATERIALS

Cardioids reveal self-organizing principles of human cardiogenesis

(2021) Pablo Hofbauer et al.   CELL

Iterative tomography with digital adaptive optics permits hour-long intravital observation of 3D subcellular dynamics at millisecond scale

(2021) Jiamin Wu et al.   CELL

MOrgAna: accessible quantitative analysis of organoids with machine learning

(2021) Nicola Gritti et al.   DEVELOPMENT

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

(2021) Carlos Pérez-González et al.   NATURE CELL BIOLOGY

Reinforcing neuron extraction and spike inference in calcium imaging using deep self-supervised denoising

(2021) Xinyang Li et al.   NATURE METHODS

Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

(2021) Srivatsan Raghavan et al.   CELL

SARS-CoV-2 infection and replication in human gastric organoids

(2021) Giovanni Giuseppe Giobbe et al.   Nature Communications

Super-resolution fluorescence-assisted diffraction computational tomography reveals the three-dimensional landscape of the cellular organelle interactome

(2020) Dashan Dong et al.   Light-Science & Applications

In Situ Expansion, Differentiation and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid

(2020) Molly E Kupfer et al.   CIRCULATION RESEARCH

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

(2020) Pedro Rifes et al.   NATURE BIOTECHNOLOGY

Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine

(2020) Krijn K. Dijkstra et al.   Cell Reports

CytoCensus, mapping cell identity and division in tissues and organs using machine learning

(2020) Martin Hailstone et al.   eLife

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Subsurface chemical nanoidentification by nano-FTIR spectroscopy

(2020) Lars Mester et al.   Nature Communications

Mechano-modulatory synthetic niches for liver organoid derivation

(2020) Giovanni Sorrentino et al.   Nature Communications

Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids

(2020) Maria-Patapia Zafeiriou et al.   Nature Communications

Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

(2020) Kevin Berthenet et al.   Cell Reports

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

(2020) Nathalie Brandenberg et al.   Nature Biomedical Engineering

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Recapitulating macro-scale tissue self-organization through organoid bioprinting

(2020) Jonathan A. Brassard et al.   NATURE MATERIALS

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

(2020) Kynan T. Lawlor et al.   NATURE MATERIALS

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs

(2020) Federica Michielin et al.   Cell Reports

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease

(2020) Juan Yin et al.   ACS Biomaterials-Science & Engineering

Controlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions

(2019) Julia Y. Co et al.   Cell Reports

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

(2019) Stefano L. Giandomenico et al.   NATURE NEUROSCIENCE

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

High-resolution 3D imaging of fixed and cleared organoids

(2019) Johanna F. Dekkers et al.   Nature Protocols

Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids

(2019) Rie Ouchi et al.   Cell Metabolism

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording

(2019) Yunlong Zhao et al.   Nature Nanotechnology

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

Organoids by design

(2019) Takanori Takebe et al.   SCIENCE

Cancer modeling meets human organoid technology

(2019) David Tuveson et al.   SCIENCE

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development

(2019) Cleber A. Trujillo et al.   Cell Stem Cell

Self-organized formation of developing appendages from murine pluripotent stem cells

(2019) Shunsuke Mori et al.   Nature Communications

A Bayesian machine learning approach for drug target identification using diverse data types

(2019) Neel S. Madhukar et al.   Nature Communications

OrgaQuant: Human Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks

(2019) Timothy Kassis et al.   Scientific Reports

Cell-mediated matrix stiffening accompanies capillary morphogenesis in ultra-soft amorphous hydrogels

(2019) Benjamin A. Juliar et al.   BIOMATERIALS

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

(2018) Suk Hyung Lee et al.   CELL

Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment

(2018) Lian-Hua Fu et al.   CHEMICAL SOCIETY REVIEWS

Organoid Modeling of the Tumor Immune Microenvironment

(2018) James T. Neal et al.   CELL

Immune context characterization and heterogeneity in primary tumors and pulmonary metastases from renal cell carcinoma

(2018) Melissa Bersanelli et al.   Immunotherapy

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis

(2017) Aleeza Farrukh et al.   Stem Cell Reports

Development-on-chip:in vitroneural tube patterning with a microfluidic device

(2016) Christopher J. Demers et al.   DEVELOPMENT

Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

(2016) C Bardy et al.   MOLECULAR PSYCHIATRY

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids

(2016) Richard J. McMurtrey   TISSUE ENGINEERING PART C-METHODS

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Fluorescent Hydrogels for Embryoid Body Formation and Osteogenic Differentiation of Embryonic Stem Cells

(2015) Nicole I. zur Nieden et al.   ACS Applied Materials & Interfaces

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Dripping and jetting in microfluidic multiphase flows applied to particle and fibre synthesis

(2013) J K Nunes et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Monodisperse collagen–gelatin beads as potential platforms for 3D cell culturing

(2013) Shaohua Ma et al.   Journal of Materials Chemistry B

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

DNA methylation in stem cell renewal and multipotency

(2011) María Berdasco et al.   Stem Cell Research & Therapy

Cell-laden microengineered gelatin methacrylate hydrogels

(2010) Jason W. Nichol et al.   BIOMATERIALS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE