Diversity Models and Applications of 3D Breast Tumor-on-a-Chip

Three‑dimensional models to study breast cancer (Review)

(2021) Maira Huerta‑Reyes et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Healing Effect of Subcutaneous Administration of G-CSF on Acute Rotator Cuff Injury in a Rat Model

(2021) Yusuke Kobayashi et al.   TISSUE ENGINEERING PART A

High throughput microfluidic system with multiple oxygen levels for the study of hypoxia in tumor spheroids

(2021) Ilana Berger Fridman et al.   Biofabrication

Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model

(2021) Mouhita Humayun et al.   BIOMATERIALS

Breast tumor-on-chip models: From disease modeling to personalized drug screening

(2021) Bano Subia et al.   JOURNAL OF CONTROLLED RELEASE

Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications

(2021) Roberto Paoli et al.   SENSORS

Integration of Electrospun Membranes into Low-Absorption Thermoplastic Organ-on-Chip

(2021) Johanna Chuchuy et al.   ACS Biomaterials-Science & Engineering

A New Anti-Estrogen Discovery Platform Identifies FDA-Approved Imidazole Anti-Fungal Drugs as Bioactive Compounds against ERα Expressing Breast Cancer Cells

(2021) Manuela Cipolletti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

(2021) Benjamin Fook Lun Lai et al.   Nature Protocols

Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system

(2021) Sandra F. Lam et al.   Scientific Reports

Three-dimensional decellularized tumor extracellular matrices with different stiffness as bioengineered tumor scaffolds

(2021) Yonggang Lv et al.   Bioactive Materials

Macrophage-Mediated Delivery of Multifunctional Nanotherapeutics for Synergistic Chemo–Photothermal Therapy of Solid Tumors

(2020) Van Du Nguyen et al.   ACS Applied Materials & Interfaces

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Polylactic is a Sustainable, Low Absorption, Low Autofluorescence Alternative to Other Plastics for Microfluidic and Organ-on-Chip Applications

(2020) Alfredo E. Ongaro et al.   ANALYTICAL CHEMISTRY

A Relatively Small Gradient of Extracellular pH Directs Migration of MDA-MB-231 Cells In Vitro

(2020) Eiji Takahashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Three dimensional engineered models to study hypoxia biology in breast cancer

(2020) Vaishali Aggarwal et al.   CANCER LETTERS

A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

(2020) Junmin Lee et al.   Small

Human-derived osteoblast-like cells and pericyte-like cells induce distinct metastatic phenotypes in primary breast cancer cells

(2020) Vera Mayo et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

In vitro modeling of solid tumor interactions with perfused blood vessels

(2020) Tae Joon Kwak et al.   Scientific Reports

Biological Performance of Electrospun Polymer Fibres

(2019) Ivan Hall Barrientos et al.   Materials

Systematic Analysis of Different Cell Spheroids with a Microfluidic Device Using Scanning Electrochemical Microscopy and Gene Expression Profiling

(2019) Liang Zhao et al.   ANALYTICAL CHEMISTRY

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

(2019) Haitao Liu et al.   ADVANCED MATERIALS

A microfluidic mammary gland coculture model using parallel 3D lumens for studying epithelial-endothelial migration in breast cancer

(2019) Deepika Devadas et al.   Biomicrofluidics

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

(2019) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

An engineered tumor-on-a-chip device with breast cancer-immune cell interactions for assessing T-cell recruitment

(2019) Aereas Aung et al.   CANCER RESEARCH

Stiffness Sensing in Cells and Tissues

(2019) Paul A. Janmey et al.   PHYSIOLOGICAL REVIEWS

Long-term monitoring in a microfluidic system to study tumour spheroid response to chronic and cycling hypoxia

(2019) Samantha M. Grist et al.   Scientific Reports

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

(2019) Yuji Nashimoto et al.   BIOMATERIALS

Co-culture of tumor spheroids and monocytes in a collagen matrix-embedded microfluidic device to study the migration of breast cancer cells

(2018) Tianying Yuan et al.   CHINESE CHEMICAL LETTERS

Overview of Silk Fibroin Use in Wound Dressings

(2018) Mehdi Farokhi et al.   TRENDS IN BIOTECHNOLOGY

Mammary fibroblasts reduce apoptosis and speed estrogen-induced hyperplasia in an organotypic MCF7-derived duct model

(2018) Molly M. Morgan et al.   Scientific Reports

Comparison of covalently and physically cross-linked collagen hydrogels on mediating vascular network formation for engineering adipose tissue

(2018) Chia-Hui Chuang et al.   Artificial Cells Nanomedicine and Biotechnology

Construction of a 3D mammary duct based on spatial localization of the extracellular matrix

(2018) Youngkyu Cho et al.   NPG Asia Materials

Rapid prototyping of cyclic olefin copolymer (COC) microfluidic devices

(2017) S. Ali Aghvami et al.   SENSORS AND ACTUATORS B-CHEMICAL

Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models

(2017) María Virumbrales-Muñoz et al.   Scientific Reports

Multiscale image analysis reveals structural heterogeneity of the cell microenvironment in homotypic spheroids

(2017) Alexander Schmitz et al.   Scientific Reports

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression

(2016) Marta F. Estrada et al.   BIOMATERIALS

Mesothelial cells interact with tumor cells for the formation of ovarian cancer multicellular spheroids in peritoneal effusions

(2016) Isabelle Matte et al.   CLINICAL & EXPERIMENTAL METASTASIS

Characterization of Cell-Type-Specific Drug Transport and Resistance of Breast Cancers Using Tumor-Microenvironment-on-Chip

(2016) Kyeonggon Shin et al.   MOLECULAR PHARMACEUTICS

Application of Collagen Scaffold in Tissue Engineering: Recent Advances and New Perspectives

(2016) Chanjuan Dong et al.   Polymers

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform

(2014) Andrew D. Wong et al.   CANCER RESEARCH

Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells

(2014) Arno Amann et al.   PLoS One

Three-dimensional spheroids of adipose-derived mesenchymal stem cells are potent initiators of blood vessel formation in porous polyurethane scaffolds

(2013) M.W. Laschke et al.   Acta Biomaterialia

Designing a tunable 3D heterocellular breast cancer tissue test system

(2013) C. C Yang et al.   Journal of Tissue Engineering and Regenerative Medicine

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Disease-on-a-chip: mimicry of tumor growth in mammary ducts

(2013) Pierre-Alexandre Vidi et al.   LAB ON A CHIP

Evaluation of Nanoparticle Uptake in Co-culture Cancer Models

(2013) Elisabete C. Costa et al.   PLoS One

Effect of homotypic and heterotypic interaction in 3D on the E-selectin mediated adhesive properties of breast cancer cell lines

(2012) Siddarth Chandrasekaran et al.   BIOMATERIALS

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

The advantages of co-culture over mono cell culture in simulating in vivo environment

(2012) Yasuhiro Miki et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Development of Multicellular Tumor Spheroid (MCTS) Culture from Breast Cancer Cell and a High Throughput Screening Method Using the MTT Assay

(2012) Wan Yong Ho et al.   PLoS One

Prototyping chips in minutes: Direct Laser Plotting (DLP) of functional microfluidic structures

(2012) Limu Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

(2011) Amy Y. Hsiao et al.   BIOMEDICAL MICRODEVICES

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

(2011) Amy Y. Hsiao et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

(2011) Paolo Cirri et al.   CANCER AND METASTASIS REVIEWS

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

(2011) Meggie M.G. Grafton et al.   Integrative Biology

On-chip cell migration assay for quantifying the effect of ethanol on MCF-7 human breast cancer cells

(2011) Xiaowen Huang et al.   Microfluidics and Nanofluidics

In vitro three-dimensional (3D) models in cancer research: An update

(2011) Lauren C. Kimlin et al.   MOLECULAR CARCINOGENESIS

Materials fabrication from Bombyx mori silk fibroin

(2011) Danielle N Rockwood et al.   Nature Protocols

Spheroid Assay to Measure TGF-β-induced Invasion

(2011) Hildegonda P.H. Naber et al.   Jove-Journal of Visualized Experiments

3D tumour models: novel in vitro approaches to cancer studies

(2011) Agata Nyga et al.   Journal of Cell Communication and Signaling

Engineering systems for the generation of patterned co-cultures for controlling cell–cell interactions

(2010) Hirokazu Kaji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

(2010) Tae-Hee Kim et al.   BIOMATERIALS

Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening

(2010) Michael C. W. Chen et al.   BIOMEDICAL MICRODEVICES

Polymerization and matrix physical properties as important design considerations for soluble collagen formulations

(2010) S.T. Kreger et al.   BIOPOLYMERS

Direct Comparisons of the Morphology, Migration, Cell Adhesions, and Actin Cytoskeleton of Fibroblasts in Four Different Three-Dimensional Extracellular Matrices

(2010) Kirsi M. Hakkinen et al.   TISSUE ENGINEERING PART A

Engineering liver tissue spheroids with inverted colloidal crystal scaffolds

(2009) Jungwoo Lee et al.   BIOMATERIALS

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Synthesis of polycaprolactone: a review

(2009) Marianne Labet et al.   CHEMICAL SOCIETY REVIEWS

Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids

(2009) Yu-suke Torisawa et al.   Integrative Biology

Microcavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue models

(2008) Daniel Kloß et al.   BIOSENSORS & BIOELECTRONICS

Hybrid Multicomponent Hydrogels for Tissue Engineering

(2008) Xinqiao Jia et al.   MACROMOLECULAR BIOSCIENCE