Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro

Organoid engineering with microfluidics and biomaterials for liver, lung disease, and cancer modeling

(2021) Su Kyeom Kim et al.   Acta Biomaterialia

Organoid and Spheroid Tumor Models: Techniques and Applications

(2021) Sreenivasulu Gunti et al.   Cancers

Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system

(2021) Hafiz Muhammad Umer Farooqi et al.   Nano Convergence

The Synergy between Organ-on-a-Chip and Artificial Intelligence for the Study of NAFLD: From Basic Science to Clinical Research

(2021) Francesco De Chiara et al.   Biomedicines

Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

(2021) Manush Saydmohammed et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

From hepatitis A to E: A critical review of viral hepatitis

(2021) Daniel Castaneda et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Modeling nonalcoholic fatty liver disease on a liver lobule chip with dual blood supply

(2021) Kun Du et al.   Acta Biomaterialia

Organ-on-chip applications in drug discovery: an end user perspective

(2021) Naomi Clapp et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids

(2021) Yao Teng et al.   BIOMATERIALS

Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation

(2021) Victoria L. Slaughter et al.   Scientific Reports

Modeling alcohol-associated liver disease in a human Liver-Chip

(2021) Janna C. Nawroth et al.   Cell Reports

Breaking the Third Wall: Implementing 3D-Printing Techniques to Expand the Complexity and Abilities of Multi-Organ-on-a-Chip Devices

(2021) Yoel Goldstein et al.   Micromachines

Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system

(2021) Tomasz Kostrzewski et al.   Communications Biology

A 3D bio-printed spheroids based perfusion in vitro liver on chip for drug toxicity assays

(2021) Tian Tian et al.   CHINESE CHEMICAL LETTERS

Development of a Hybrid Polymer-Based Microfluidic Platform for Culturing Hepatocytes towards Liver-on-a-Chip Applications

(2021) Gulsim Kulsharova et al.   Polymers

Design and Fabrication of Organ-on-Chips: Promises and Challenges

(2021) Alireza Tajeddin et al.   Micromachines

Hepatocyte cultures: From collagen gel sandwiches to microfluidic devices with integrated biosensors

(2021) Jose M. de Hoyos-Vega et al.   APL Bioengineering

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Liver‐on‐a‐Chip Models of Fatty Liver Disease

(2020) Shabir Hassan et al.   HEPATOLOGY

Bioengineered 3D Models to Recapitulate Tissue Fibrosis

(2020) Marta Sacchi et al.   TRENDS IN BIOTECHNOLOGY

Application of Gelatin Bioinks and Cell-Printing Technology to Enhance Cell Delivery Capability for 3D Liver Fibrosis-on-a-Chip Development

(2020) Hyungseok Lee et al.   ACS Biomaterials-Science & Engineering

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Sadaf G Sepanlou et al.   Lancet Gastroenterology & Hepatology

Human multi-organ chip co-culture of bronchial lung culture and liver spheroids for substance exposure studies

(2020) Katharina Schimek et al.   Scientific Reports

Beyond polydimethylsiloxane: Alternative materials for fabrication of organ on a chip devices and microphysiological systems

(2020) Scott Campbell et al.   ACS Biomaterials-Science & Engineering

Hepatic Stellate Cells and Hepatocarcinogenesis

(2020) Anna E. Barry et al.   Frontiers in Cell and Developmental Biology

Microfluidic organ-on-a-chip models of human liver tissue

(2020) Ehsanollah Moradi et al.   Acta Biomaterialia

Spheroids as a Type of Three-Dimensional Cell Cultures—Examples of Methods of Preparation and the Most Important Application

(2020) Kamila Białkowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Organs-on-chips: into the next decade

(2020) Lucie A. Low et al.   NATURE REVIEWS DRUG DISCOVERY

Modeling Human Nonalcoholic Fatty Liver Disease (NAFLD) with an Organoids-on-a-Chip System

(2020) Yaqing Wang et al.   ACS Biomaterials-Science & Engineering

Microtechnology-based methods for organoid models

(2020) Vanessa Velasco et al.   Microsystems & Nanoengineering

Organ-on-a-Chip Systems for Modeling Pathological Tissue Morphogenesis Associated with Fibrosis and Cancer

(2020) Kristen L. Hayward et al.   ACS Biomaterials-Science & Engineering

In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal

(2020) Pierre-Antoine Soret et al.   Journal of Clinical Medicine

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

(2019) Ana Maria Ortega-Prieto et al.   Jove-Journal of Visualized Experiments

A cell lines derived microfluidic liver model for investigation of hepatotoxicity induced by drug-drug interaction

(2019) Jiu Deng et al.   Biomicrofluidics

Challenges and Opportunities in the Design of Liver-on-Chip Microdevices

(2019) Avner Ehrlich et al.   Annual Review of Biomedical Engineering

A liver-chip-based alcoholic liver disease model featuring multi-non-parenchymal cells

(2019) Jiu Deng et al.   BIOMEDICAL MICRODEVICES

Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis

(2019) Andrew M. Moon et al.   Clinical Gastroenterology and Hepatology

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

In Vitro Human Liver Model of Nonalcoholic Steatohepatitis by Coculturing Hepatocytes, Endothelial Cells, and Kupffer Cells

(2019) Ceri‐Anne E. Suurmond et al.   Advanced Healthcare Materials

Engineered Liver-on-a-Chip Platform to Mimic Liver Functions and Its Biomedical Applications: A Review

(2019) Deng et al.   Micromachines

Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

(2019) Kaarj et al.   Micromachines

A systematic investigation of the effect of the fluid shear stress on Caco-2 cells towards the optimization of epithelial organ-on-chip models

(2019) Ludivine C. Delon et al.   BIOMATERIALS

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Bile Acid Metabolism in Liver Pathobiology

(2018) John Y. L. Chiang et al.   GENE EXPRESSION

Liver fibrosis

(2018) M. Merve Aydin et al.   Turkish Journal of Gastroenterology

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

(2018) A. M. Ortega-Prieto et al.   Nature Communications

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

(2018) Sigrid A. Langhans   Frontiers in Pharmacology

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study

(2017) Young Kang et al.   Micromachines

Cell sources for in vitro human liver cell culture models

(2016) Katrin Zeilinger et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Judging the value of ‘liver-on-a-chip’ devices for prediction of toxicity

(2016) Viktoriia Starokozhko et al.   Expert Opinion on Drug Metabolism & Toxicology

A 3D alcoholic liver disease model on a chip

(2016) JaeSeo Lee et al.   Integrative Biology

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

(2016) Christine Lin et al.   Biomed Research International

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

(2016) Manuele Gori et al.   PLoS One

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro

(2016) Deborah G. Nguyen et al.   PLoS One

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

(2016) Carlota Oleaga et al.   Scientific Reports

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Three-Dimensional Cell Culture: A Breakthrough in Vivo

(2015) Delphine Antoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver injury-on-a-chip: microfluidic co-cultures with integrated biosensors for monitoring liver cell signaling during injury

(2015) Qing Zhou et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

(2014) Nobuyuki Toshikuni   WORLD JOURNAL OF GASTROENTEROLOGY

Drug-Induced Liver Injury: The Role of Drug Metabolism and Transport

(2013) Alberto Corsini et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

(2013) Seung-A Lee et al.   LAB ON A CHIP

Animal models of chronic liver diseases

(2012) Yan Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Molecular mechanisms underlying chemical liver injury

(2012) Xinsheng Gu et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Scaling Down of a Clinical Three-Dimensional Perfusion Multicompartment Hollow Fiber Liver Bioreactor Developed for Extracorporeal Liver Support to an Analytical Scale Device Useful for Hepatic Pharmacological In Vitro Studies

(2011) Katrin Zeilinger et al.   TISSUE ENGINEERING PART C-METHODS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Incorporation of multicellular spheroids into 3-D polymeric scaffolds provides an improved tumor model for screening anticancer drugs

(2010) Won Jin Ho et al.   CANCER SCIENCE

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Liver tissue engineering in the evaluation of drug safety

(2009) Ajit Dash et al.   Expert Opinion on Drug Metabolism & Toxicology

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET