Organ-on-a-chip platforms as novel advancements for studying heterogeneity, metastasis, and drug efficacy in breast cancer

Biomimetic sulfated glycosaminoglycans maintain differentiation markers of breast epithelial cells and preferentially inhibit proliferation of cancer cells

(2021) Zeina Habli et al.   Acta Biomaterialia

Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology

(2021) Seong-Hye Hwang et al.   Micromachines

Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer Research

(2021) Fahriye Duzagac et al.   Cancers

Organ-on-a-chip: recent breakthroughs and future prospects

(2020) Qirui Wu et al.   Biomedical Engineering Online

Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

(2020) Andrew E. Miller et al.   Advanced Healthcare Materials

Breast Cancer and Nutrition: A Paradigm for Prevention in 3D Across the Life Course

(2020) Michele R. Forman   Frontiers in Oncology

An integrated array chip for high-throughput screening species differences in metabolism

(2020) Xiaoni Ai et al.   ANALYTICAL CHEMISTRY

Collective cell migration of fibroblasts is affected by horizontal vibration of the cell culture dish

(2020) Umi Enomoto et al.   ENGINEERING IN LIFE SCIENCES

A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

(2020) Junmin Lee et al.   Small

A new drug testing platform based on 3D tri-culture in lab-on-a-chip devices

(2020) Begum Gokce et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback

(2019) Denis Menshykau et al.   Nature Communications

Organ-on-a-Chip for Cancer and Immune Organs Modeling

(2019) Wujin Sun et al.   Advanced Healthcare Materials

Connexin 43 Loss Triggers Cell Cycle Entry and Invasion in Non-Neoplastic Breast Epithelium: A Role for Noncanonical Wnt Signaling

(2019) Sabreen Fostok et al.   Cancers

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

An engineered tumor-on-a-chip device with breast cancer-immune cell interactions for assessing T-cell recruitment

(2019) Aereas Aung et al.   CANCER RESEARCH

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Vascularized microfluidic platforms to mimic the tumor microenvironment

(2018) Rhys Michna et al.   BIOTECHNOLOGY AND BIOENGINEERING

Differences in breast cancer incidence among young women aged 20–49 years by stage and tumor characteristics, age, race, and ethnicity, 2004–2013

(2018) Meredith L. Shoemaker et al.   BREAST CANCER RESEARCH AND TREATMENT

The breast tumor microenvironment: role in cancer development, progression and response to therapy

(2018) Suruchi Mittal et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

(2018) Carsten Denkert et al.   LANCET ONCOLOGY

A Spontaneous 3D Bone-On-a-Chip for Bone Metastasis Study of Breast Cancer Cells

(2018) Sijie Hao et al.   Small

Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture

(2018) Liting Jin et al.   Oncotarget

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

Advances in circular RNAs and their roles in breast Cancer

(2018) Xuehui Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing

(2018) Siming Lu et al.   LAB ON A CHIP

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

(2018) Marie Nguyen et al.   Cell Reports

Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasis

(2017) Akshay A. Narkhede et al.   INTERNATIONAL JOURNAL OF CANCER

A novel 3-D bio-microfluidic system mimicking in vivo heterogeneous tumour microstructures reveals complex tumour–stroma interactions

(2017) Qihui Fan et al.   LAB ON A CHIP

Bridging the gap: microfluidic devices for short and long distance cell–cell communication

(2017) Timothy Quang Vu et al.   LAB ON A CHIP

Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1

(2017) N Cohen et al.   ONCOGENE

CircRNA: a novel type of biomarker for cancer

(2017) He-da Zhang et al.   Breast Cancer

Multiwell capillarity-based microfluidic device for the study of 3D tumour tissue-2D endothelium interactions and drug screening in co-culture models

(2017) María Virumbrales-Muñoz et al.   Scientific Reports

microRNA Expression in Ethnic Specific Early Stage Breast Cancer: an Integration and Comparative Analysis

(2017) Farah J. Nassar et al.   Scientific Reports

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

(2016) Zhongyu Li et al.   Integrative Biology

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

A novel microfluidic model can mimic organ-specific metastasis of circulating tumor cells

(2016) Jing Kong et al.   Oncotarget

An Engineered Breast Cancer Model on a Chip to Replicate ECM-Activation In Vitro during Tumor Progression

(2016) Filomena Gioiella et al.   Advanced Healthcare Materials

High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer

(2016) Cailu Song et al.   Scientific Reports

Mammary gland development: cell fate specification, stem cells and the microenvironment

(2015) J. L. Inman et al.   DEVELOPMENT

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Microfluidics for cell-cell interactions: A review

(2015) Rui Li et al.   Frontiers of Chemical Science and Engineering

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial

(2014) S. Loi et al.   ANNALS OF ONCOLOGY

A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone

(2014) Simone Bersini et al.   BIOMATERIALS

A microphysiological system model of therapy for liver micrometastases

(2014) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

3D Cell Culture Systems: Advantages and Applications

(2014) Maddaly Ravi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The promise of organotypic hepatic and gastrointestinal models

(2014) Lucas T. Vu et al.   TRENDS IN BIOTECHNOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Building risk-on-a-chip models to improve breast cancer risk assessment and prevention

(2013) Pierre-Alexandre Vidi et al.   Integrative Biology

Disease-on-a-chip: mimicry of tumor growth in mammary ducts

(2013) Pierre-Alexandre Vidi et al.   LAB ON A CHIP

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Role of tumor vascular architecture in drug delivery

(2011) Ajit S. Narang et al.   ADVANCED DRUG DELIVERY REVIEWS

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

(2011) Meggie M.G. Grafton et al.   Integrative Biology

A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening

(2011) Jean-Matthieu Prot et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Advances in the preclinical testing of cancer therapeutic hypotheses

(2011) Giordano Caponigro et al.   NATURE REVIEWS DRUG DISCOVERY

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Engineered dermal equivalent tissue in vitro by assembly of microtissue precursors

(2010) Carmela Palmiero et al.   Acta Biomaterialia

The molecular pathology of breast cancer progression

(2010) Alessandro Bombonati et al.   JOURNAL OF PATHOLOGY

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Viability analysis and apoptosis induction of breast cancer cells in a microfluidic device: effect of cytostatic drugs

(2008) Job Komen et al.   BIOMEDICAL MICRODEVICES

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE