Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip

New technologies in drug metabolism and toxicity screening: organ-to-organ interaction

(2016) Abhinav Bhushan et al.   Expert Opinion on Drug Metabolism & Toxicology

Modeling type 2 diabetes-like hyperglycemia in C. elegans on a microdevice

(2016) Guoli Zhu et al.   Integrative Biology

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies

(2016) Hanming Cui et al.   MOLECULES

An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector

(2015) Jie Zhang et al.   BIOSENSORS & BIOELECTRONICS

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations

(2015) Christian Queckenberg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles

(2015) Shi Qing Tang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Discovery Channel: microfluidics and microengineered systems in drug screening

(2015) Christopher Moraes   Integrative Biology

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

(2015) Hasan Erbil Abaci et al.   Integrative Biology

A droplet microchip with substance exchange capability for the developmental study of C. elegans

(2015) Hui Wen et al.   LAB ON A CHIP

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

(2015) Da Yoon No et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Human hepatoma cell lines on gas foaming templated alginate scaffolds for in vitro drug-drug interaction and metabolism studies

(2015) A. Stampella et al.   TOXICOLOGY IN VITRO

First pass intestinal and liver metabolism of paracetamol in a microfluidic platform coupled with a mathematical modeling as a means of evaluating ADME processes in humans

(2014) Jean Matthieu Prot et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a novel multi-layer microfluidic device towards characterization of drug metabolism and cytotoxicity for drug screening

(2014) Qin Wu et al.   CHEMICAL COMMUNICATIONS

Thymidine phosphorylase influences [18F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer

(2014) Seung Jin Lee et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

(2014) Manjunath Hegde et al.   LAB ON A CHIP

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

(2014) Mandy B. Esch et al.   LAB ON A CHIP

The promise of organotypic hepatic and gastrointestinal models

(2014) Lucas T. Vu et al.   TRENDS IN BIOTECHNOLOGY

Induction of epithelial-to-mesenchymal transition in proximal tubular epithelial cells on microfluidic devices

(2013) Mengying Zhou et al.   BIOMATERIALS

Lidamycin up-regulates the expression of thymidine phosphorylase and enhances the effects of capecitabine on the growth and pulmonary metastases of murine breast carcinoma

(2013) Sheng-hua Zhang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

(2013) Edmond W. K. Young   Integrative Biology

Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip

(2013) Hui Wen et al.   Integrative Biology

Reinventing clinical trials

(2012) Malorye Allison   NATURE BIOTECHNOLOGY

Monitoring induced gene expression of single cells in a multilayer microchip

(2011) C. Hanke et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

(2011) Paul M. van Midwoud et al.   Integrative Biology

Imitation of drug metabolism in human liver and cytotoxicity assay using a microfluidic device coupled to mass spectrometric detection

(2011) Sifeng Mao et al.   LAB ON A CHIP

Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity

(2010) Yuki Imura et al.   ANALYTICAL CHEMISTRY

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices

(2010) Kiana Aran et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Characterization of drug metabolites and cytotoxicity assay simultaneously using an integrated microfluidic device

(2008) Bo Ma et al.   LAB ON A CHIP